Molecular and genetic defects in colorectal tumorigenesis

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 16, Issue 2, 2002, Pages 171-185

  Tejpar, Sabine ^a   Van Cutsem, Eric ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

APC; Colorectal cancer; FAP; HNPCC; Tumorigenesis

Indexed keywords

APC PROTEIN; AXIN; BETA CATENIN; CYCLIN D1; FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; WNT PROTEIN; APC;

ADENOMATOUS POLYP; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL POPULATION; CHROMOSOME DISORDER; COLORECTAL CANCER; CRYPT CELL; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; HOMEOSTASIS AND REGULATION; HUMAN; MICROSATELLITE INSTABILITY; NONHUMAN; PROGNOSIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; COLON POLYPOSIS; COLORECTAL TUMOR; DISEASE COURSE; FAMILIAL CANCER; GENETICS; HOSPITALIZATION; REVIEW; RISK FACTOR; CANCER INVASION; CANCER RISK; CANCER SCREENING; CANCER SURGERY; CANCER THERAPY; CHROMOSOMAL INSTABILITY; CLINICAL FEATURE; COLORECTAL ADENOMA; GASTROINTESTINAL ENDOSCOPY; GENETIC DISORDER; GENETIC TRANSCRIPTION; HIGH RISK POPULATION; HOMEOSTASIS; INTESTINE CRYPT; PATHOGENICITY;

ADENOMATOUS POLYPOSIS COLI; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DISEASE PROGRESSION; HUMANS; NEOPLASTIC SYNDROMES, HEREDITARY; PROGNOSIS; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 0036550778     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1053/bega.2001.0279     Document Type: Article

References (49)

1. Hanahan D Weinberg R A The hallmarks of cancer Cell 100 2000 57-70
2. Fearon E R Vogelstein B A genetic model for colorectal tumorigenesis Cell 61 1990 759-767
3. Kinzler K W Vogelstein B Lessons from hereditary colorectal cancer Cell 87 1996 159-170
4. Vogelstein B Fearon E R Hamilton S R Genetic alterations during colorectal-tumor development New England Journal of Medicine 319 1988 525-532
5. Laurent-Puig P Blons H Cugnenc P H Sequence of molecular genetic events in colorectal tumorigenesis European Journal of Cancer Prevention 8 1999 S39-S47
6. Bach S P Renehan A G Potten C S Stem cells: the intestinal stem cell as a paradigm Carcinogenesis 21 2000 469-476
7. Wasan H S Park H S Liu K C et al. APC in the regulation of intestinal crypt fission Journal of Pathology 185 1998 246-255
8. Powell S M Zilz N Beazer-Barclay Y et al. APC mutations occur early during colorectal tumorigenesis Nature 359 1992 235-237
9. Su L-K Vogelstein B Kinzler K W Association of the APC tumor suppressor protein with catenins Science 262 1993 1734-1737
10. Rubinfeld B Souza B Albert I et al. Association of the APC gene product with beta-catenin Science 262 1993 1731-1734
11. Nishisho I Nakamura Y Miyoshi Y et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients Science 253 1991 665-669
12. Goss K H Groden J Biology of the adenomatous polyposis coli tumor suppressor Journal of Clinical Oncology 18 2000 1967-1979
13. Behrens J Jerchow B A Wurtele M et al. Functional interaction of an axin homolog, conductin, with β-catenin, APC and GSKβ Science 280 1998 596-599
14. Hart M Concordet J P Lassot I et al. The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell Current Biology 9 1999 207-210
15. Kuhl M Wedlich D Wnt signalling goes nuclear Bioessays 19 1997 101-104
16. Behrens J von Der Kries J P Kuhl M et al. Functional interaction of β-catenin with the transcription factor Lef-1 Nature 382 1996 638-642
17. Tetsu O McCormick F β-Catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422-426
18. He T C Sparks A B Rago C et al. Identification of c-Myc as a target of the APC pathway Science 281 1998 1509-1512
19. Laurent M Blitz I L Hashimoto C et al. The Xenopus homeobox gene Twin mediates Wnt induction of goosecosoid in establishment of Spemann's organizer Development 124 1997 4905-4916
20. Sparks A B Morin P J Vogelstein B Kinzler K W Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer Cancer Research 58 1998 1130-1134
21. Samowitz W S Powers M D Spirio L N et al. β-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas Cancer Research 59 1999 1442-1444
22. Mann B Gelos M Siedow A et al. Target genes of beta-catenin-T-cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas Proceedings of the National Academy of Sciences of the USA 96 1999 1603-1608
23. Lengauer C Kinzler K W Vogelstein B Genetic instabilities in human cancers Nature 396 1998 643-649
24. Cahill D P Lengauer C Yu J et al. Mutations of mitotic checkpoint genes in human cancers Nature 392 1998 300-303
25. Fodde R Kuipers J Rosenberg C et al. Mutations in the APC tumour suppressor gene cause chromosomal instability Nature Cell Biology 3 2001 433-438
26. Bubb V J Curtis L J Cunningham C et al. Microsatellite instability and the role of hMSH2 in sporadic colorectal cancer Oncogene 12 1996 2641-2649
27. Chang D K Metzgar D Wills C Boland C R Microsatellites in the eukaryotic DNA mismatch repair genes as modulators of evolutionary mutation rate Genome Research 11 2001 1145-1146
28. Schmutte C Fishel R Genomic instability: first step to carcinogenesis Anticancer Research 19 1999 4665-4696
29. Kolodner R Biochemistry and genetics of eukaryotic mismatch repair Genes and Development 10 1996 1433-1442
30. Gradia S Acharya S Fishel R The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch Journal of Biological Chemistry 275 2000 3922-3930
31. Fishel R Signaling mismatch repair in cancer Nature Medicine 5 1999 1239-1241
32. Markowitz S Wang J Myeroff L et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability Science 268 1995 1336-1338
33. Liu B Parsons R Papadopoulos N et al. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients Nature Medicine 2 1996 169-174
34. Bos J L Fearon E R Hamilton S R et al. Prevalence of ras gene mutations in human colorectal cancers Nature 327 1987 293-297
35. Markowitz S Roberts A Tumor suppressor activity of the TGF-pathway in human cancers Cytokine and Growth Factor Reviews 7 1996 93-102
36. Eppert K Scherer S W Ozcelik H et al. MADR2 maps to 18q21 and encodes a TGF-beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma Cell 86 1996 543-552
37. Baba S Hereditary nonpolyposis colorectal cancer, an update Diseases of the Colon and the Rectum 40 1997 S86-S95
38. Aaltonen L Incidence of hereditary nonpolyposis colorectal cancer and the feasability of molecular screening for the disease New England Journal of Medicine 338 1998 1481-1487
39. Boland C R Thibodeau S N Hamilton S R et al. A National Cancer Institute workshop in microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Research 58 1998 5248-5257
40. Liu B Nicolaides N C Markowitz S et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability Nature Genetics 9 1995 48-55
41. Jarvinen H J Mecklin J P Sistonen P Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer Gastroenterology 108 1995 1405-1411
42. Bulow S Familial polyposis coli Danish Medical Bulletin 34 1987 1-15
43. Giardiello F M Brensinger J D Petersen G M AGA Technical review on hereditary colorectal cancer and genetic testing Gastroenterology 121 2001 198-213
44. Moertel C G Hill J R Adson M A Surgical management of multiple polyposis Archives of Surgery 100 1970 521-526
45. Nugent K P Phillips R KS Rectal cancer risk in older patients with familial adenomatous polyposis and an ileorectal anastomosis: a cause for concern British Journal of Surgery 79 1992 1204-1206
46. van Duijvendijk P Slors J FM Taat C W et al. The cumulative risk of developing polyps or malignancy at the ileo-pouch-anal anastomosis in patients with familial adenomatous polyposis Gastroenterology 114 1998 A1432
47. American Gastroenterological Association (AGA) Clinical Practice and Practice Economics Committee. AGA Technical Review on Hereditary Colorectal Cancer and Genetic Testing. Gastroenterology 121 2001 198-213
48. Watanabe T Wu T Catalano P et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer New England Journal of Medicine 344 2001 1196-1206
49. Gryfe R Kim H Hsieh E et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer New England Journal of Medicine 342 2000 69-77