Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes

Developmental Biology

Volumn 244, Issue 1, 2002, Pages 21-36

  Zhao, Yuanxiang ^a   Potter, S Steven ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Homeobox; Kidney; Limb; Patterning; Phenotypic suppression; Reproductive tract

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEIN HOXA 11; PROTEIN HOXA 4; TRANSCRIPTION FACTOR HOXA10; UNCLASSIFIED DRUG;

ALLELISM; ARTICLE; BONE DEVELOPMENT; CHIMERA; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; DROSOPHILA; FEMALE; FEMALE GENITAL SYSTEM; GENE EXPRESSION; GENE LOCATION; GENE TARGETING; HOMEOBOX; KIDNEY DEVELOPMENT; MALE; MALE GENITAL SYSTEM; MOLECULAR BIOLOGY; MOLECULAR EVOLUTION; MOLECULAR MODEL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

MAMMALIA;

EID: 0036534442     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2002.0595     Document Type: Article

References (79)

1. HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation
2. Homeotic transformation of rhombomere identity after localized Hoxb 1 misexpression
3. The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes
4. Site-directed mutagenesis by combined chain reaction
5. Regulation of segmentation and segmental identity by Drosophila homeoproteins: The role of DNA binding in functional activity and specificity
6. Characterization of Hoxa-10/Hoxa-11 transheterozygotes reveals functional redundancy and regulatory interactions
7. The third-chromosome group of mutant characters of Drosophila melanogaster
8. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
9. Homeobox genes in leukemogenesis
10. Direct regulation of decapentaplegic by Ultrabithorax and its role in midgut morphogenesis
11. Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation
12. Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes
13. Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins
14. The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences
15. The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradencticle, another homeoprotein
16. Switching the in vivo specificity of a minimal Hox-responsive element
17. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins
18. Distinct Hox protein sequences determine specificity in different tissues
19. Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions
20. Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11
21. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11
22. The sequence specificity of homeodomain-DNA interaction
23. The vertebrate limb: A model system to study the Hox/HOM gene network during development and evolution
24. Vertebrate Hox genes and proliferation: An alternative pathway to homeosis?
25. Developmental genetics. A Hox by any other name
26. The Bithorax complex
27. Spatially restricted domains of homeo-gene transcripts in mouse embryos: Relation to a segmented body plan
28. Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton
29. Functional specificity of the Antennapedia homeodomain
30. Abnormal uterine stromal and glandular function associated with maternal reproductive defects in Hoxa 11 null mice
31. Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth
32. The developmental effect of overexpressing a Ubx product on embryos is dependent on its interactions with other homeotic products
33. Maintenance of functional equivalence during paralogous Hox gene evolution
34. The establishment of murine Hox-1 expression domains during patterning of the limb
35. Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of
36. Divergent homeo box proteins recognize similar DNA sequences in Drosophila
37. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells
38. Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility
39. Specification of distinct motor neuron identities by the singular activities of Hox genes
40. Murine developmental control genes
41. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: A framework for understanding homeodomain-DNA interactions
42. Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column
43. Evolution of the vertebrate Hox homeobox genes
44. A homeodomain substitution changes the regulatory specificity of the deformed protein in Drosophila embryos
45. The role of HOX homeobox genes in normal and leukemic hematopoiesis
46. Ectopic expression of Ubx and ABD-B proteins during Drosophila embryogenesis: Competition, not a functional hierarchy, explains phenotypic suppression
47. Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution
48. Mapping functional specificity in the Dfd and Ubx homeo domains
49. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans
50. Homeobox genes and axial patterning
51. Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution
52. Hoxa 11 and Hoxd 11 regulate branching morphogenesis of the ureteric bud in the developing kidney
53. Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
54. The interaction with DNA of wild-type and mutant fushi tarazu homeodomains
55. Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif
56. Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm
57. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation
58. Segmental expression of Hoxb-1 is controlled by a highly conserved auto-regulatory loop dependent upon exd/pbx
59. The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors
60. Compromised HOXA5 function can limit p53 expression in human breast tumours
61. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4: 11) abnormality
62. A differential response element for the homeotics at the Antennapedia P1 promoter of Drosophila
63. Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia
64. Vertebrate homeobox gene nomenclature
65. Structural relationships among genes that control development: Sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila
66. The molecular organization of the Antennapedia locus of Drosophila
67. A rapid method for preparing high quality alizarin stained skeletons of adult mice
68. The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target
69. Homeotic transformations and limb defects in Hox A11 mutant mice
70. A conserved Hox axis in the mouse and human female reproductive system: Late establishment and persistent adult expression of the Hoxa cluster genes
71. Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia
72. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia
73. Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
74. Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context
75. Two homeodomain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos
76. Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts
77. Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeodomain
78. Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomain is critical to functional specificity
79. Functional specificity of the Hoxa 13 homeobox