Comparative degradation study of biodegradable microspheres of poly(DL-lactide-co-glycolide) with poly(ethyleneglycol) derivates

Journal of Microencapsulation

Volumn 16, Issue 1, 1999, Pages 83-94

  Garcia, J T ^a   Farina J B ^a   Munguia O ^a   Llabres M ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Biodegradable polymer; Degradation; Microspheres; Poly(DL lactide co glycolide); Poly(ethyleneglycol)

Indexed keywords

MACROGOL; MICROSPHERE; POLYGLACTIN; POLYMER;

ARTICLE; BIODEGRADATION; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; DRUG HALF LIFE; MOLECULAR WEIGHT; PH; POLYMERIZATION; TEMPERATURE;

BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; DRUG CARRIERS; DRUG STABILITY; KINETICS; LACTIC ACID; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; POLYGLYCOLIC ACID; POLYMERS;

EID: 0032924617     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/026520499289338     Document Type: Article

References (13)

1. BRANNON-PEPPAS, L., 1995, Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. International Journal of Pharmaceutics, 116, 1-9.
2. COHEN, S., YOSHIOKA, T., LUCARELLI, M., HWANG, L. H., and LANGER, R., 1991, Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharmaceutical Research, 8, 713-720.
3. DORTA, M. J., MUNGUÍA, O., and LLABRÉS, M., 1993, Effects of polymerization variables on PLGA properties: molecular weight, composition and chain structure. International Journal of Pharmaceutics, 100, 9-14.
4. GREF, R., DOMB, A., QUELLEC, P., BLUNK, T., MÜLLER, R. H., VERBAVATZ, J. M., and LANGER, R., 1995, The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Advanced Drug Delivery Reviews, 16, 215-233.
5. GREF, R., MINAMITAKE, Y., PERACCHIA, M. T., TRUBETSKOY, V., TORCHILIN, V., and LANGER, R., 1994, Biodegradable long-circulating polymeric nanospheres. Science, 263, 1600-1603.
6. HEYA, T., OKADA, H., TANIGAWARA, Y., OGAWA, Y., and TOGUCHI, H., 1991a, Effects of counteranion of THR and loading amount on control of THR release from copoly(D,L-lactic/glycolic acid) microspheres prepared by an in-water drying method. International Journal of Pharmaceutics, 69, 69-75.
7. HEYA, T., OKADA, T., OGAWA, Y., and TOGUCHI, H., 1991b, Factors influencing the profiles of THR release from copoly(D,L-lactic/glycolic acid) microspheres. International Journal of Pharmaceutics, 71, 199-205.
8. KENLEY, R. A., LEE, M. O., MAHONEY, T. R., and SANDERS, L. M., 1987, Poly(lactide-co-glycolide) decomposition kinetics in vivo and in vitro. Macromolecules, 20, 2398-2403.
9. LI, S. GARREAU, H., and VERT, M., 1990a, Structure-property relationships in the case of the degradation of massive poly(α-hydroxy acids) in aqueous media, part I: poly(DL-lactic acid). Journal of Materials Science: Materials in Medicine, 1, 123-130.
10. LI, S., GARREAU, H., and VERT, M., 1990b, Structure-property relationships in the case of the degradation of massive poly(α-hydroxy acids) in aqueous media, part II: degradation of lactide-glycolide copolymers. Journal of Materials Science: Materials in Medicine, 1, 131-139.
11. PARK, T. G., 1994, Degradation of poly(DL-lactic acid) microspheres: effect of molecular weight. Journal of Controlled Release, 30, 161-173.
12. PARK, T. G., 1995, Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials, 16, 1123-1130.
13. ZHU, K. J., XIANGZHOU, L., and SHILIN, Y., 1990, Preparation, characterization and properties of polylactide (PLA)-poly(ethylene glycol) (PEG) copolymers: a potential drug carrier. Journal of Applied Polymer Science, 39, 1-9.