Expression of Xist RNA is sufficient to initiate macrochromatin body formation

Chromosoma

Volumn 110, Issue 6, 2001, Pages 411-420

  Rasmussen, T P ^a   Wutz, A ^a   Pehrson, J R ^a   Jaenisch, R ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE; RNA; UNCLASSIFIED DRUG; XIST RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOSOME ABERRATION; BIOACCUMULATION; CELL DIFFERENTIATION; CELL KINETICS; CELL LINE; CHROMATIN; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; ECTOPIC TISSUE; FIBROBLAST; FUNCTIONAL ASSESSMENT; GENE EXPRESSION; MAMMAL; MOUSE; NONHUMAN; PLACENTA; PROTEIN LOCALIZATION; REGULATORY MECHANISM; TRANSGENE; X CHROMOSOME INACTIVATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CHROMATIN; FIBROBLASTS; MALE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PROTEIN BINDING; RNA; RNA, UNTRANSLATED; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSGENES;

EID: 0035198727     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004120100158     Document Type: Article

References (23)

1. Analysis of replication timing properties of human X-chromosomal loci by fluorescence in situ hybridization
2. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome
3. XIST and the mapping of the X chromosome inactivation centre
4. Histone H2A variants and the inactive X chromosome: Identification of a second macroH2A variant
5. XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear/chromosome structure
6. Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals
7. MacroH2A2, a new member of the MacroH2A core histone family
8. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation
9. Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies
10. X-inactivation and histone H4 acetylation in embryonic stem cells
11. Targeted mutagenesis of Tsix leads to nonrandom X inactivation
12. Tsix, a gene antisense to Xist at the X-inactivation centre
13. Xist-deficient mice are defective in dosage compensation but not spermatogenesis
14. Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation
15. X chromosome inactivation is mediated by Xist RNA stabilization
16. MacroH2A, a core histone containing a large nonhistone region
17. Developmental and tissue expression patterns of histone macroH2A1 subtypes
18. Requirement for Xist in X chromosome inactivation
19. Higher concentrations of histone macroH2A in the Barr body are correlated with higher nucleosome density
20. Messenger RNAs encoding mouse histone macroH2A1 isoforms are expressed at similar levels in male and female cells and result from alternative splicing
21. Dynamic relocalization of histone MacroH2A1 from centrosomes to inactive X chromosomes during X inactivation
22. Stabilization of Xist RNA mediates initiation of X chromosome inactivation
23. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation