Dynamic relocalization of histone macroH2A1 from centrosomes to inactive X chromosomes during X inactivation

Journal of Cell Biology

Volumn 150, Issue 5, 2000, Pages 1189-1198

  Rasmussen, Theodore P ^a   Mastrangelo, Mary Ann ^a   Eden, Amir ^a   Pehrson, John R ^b   Jaenisch, Rudolf ^a,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Chromatin; Dosage compensation; Microtubule; Stem cells; Xist

Indexed keywords

GAMMA TUBULIN; HISTONE; HISTONE H2A; HISTONE MACROH2A1; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CENTROSOME; CONTROLLED STUDY; FEMALE; MALE; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL; X CHROMOSOME; X CHROMOSOME INACTIVATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CENTROSOME; CYTOCHALASIN B; FEMALE; HISTONES; IN SITU HYBRIDIZATION; MALE; MICE; NOCODAZOLE; STEM CELLS; TUBULIN; X CHROMOSOME;

ANIMALIA;

EID: 0034605124     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.5.1189     Document Type: Article

References (24)

1. Structural and chemical characterization of isolated centrosomes
2. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome
3. The human X-inactivation centre is not required for maintenance of X-chromosome inactivation
4. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
5. Localization of the X inactivation centre on the human X chromosome in Xq13
6. Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals
7. Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos
8. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation
9. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
10. X-inactivation and histone H4 acetylation in embryonic stem cells
11. A 450 kb transgene displays properties of the mammalian X-inactivation center
12. Xist-deficient mice are defective in dosage compensation but not spermatogenesis
13. X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro
14. Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation
15. Isolation of mammalian centrosomes
16. X chromosome inactivation is mediated by Xist RNA stabilization
17. MacroH2A, a core histone containing a large nonhistone region
18. Requirement for Xist in X chromosome inactivation
19. Absence of the XIST gene from late-replicating isodicentric X chromosomes in leukaemia
20. Messenger RNAs encoding mouse histone macroH2A1 isoforms are expressed at similar levels in male and female cells and result from alternative splicing
21. Gamma-tubulin is a highly conserved component of the centrosome
22. Crystallization and preliminary X-ray crystallographic studies of nonhistone region of macroH2A.1
23. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
24. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome