Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins

Human Molecular Genetics

Volumn 9, Issue 13, 2000, Pages 1977-1986

  Meister, G ^a   Buhler, D ^a   Laggerbauer, B ^a   Zobawa, M ^a   Lottspeich, F ^a   Fischer, U ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM PROTEIN; GENE PRODUCT; HELICASE; MESSENGER RNA; NUCLEAR PROTEIN; RNA; SUCROSE; SURVIVAL OF MOTOR NEURONS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL NUCLEUS; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; DEGENERATIVE DISEASE; HEREDITARY SPINAL MUSCULAR ATROPHY; HUMAN; HUMAN CELL; IMMUNOAFFINITY CHROMATOGRAPHY; MOTONEURON; MOTONEURON NUCLEUS; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; RNA SPLICING; SPLICEOSOME;

ANIMALIA;

EID: 0034641609     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.13.1977     Document Type: Article

References (33)

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4. Hungarian study on Werdnig-Hoffmann disease
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7. Histopathology of SMA
8. Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos
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10. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn mice and results in a mouse with spinal muscular atrophy
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12. A novel nuclear structure containing the survival of motor neurons protein
13. The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins
14. Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems
15. The SMN-SIP-1 complex has an essential role in spliceosomal snRNP biogenesis
16. The snRNP core assembly pathway: Identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro
17. Small nuclear ribonucleoprotein particle assembly in vivo: Demonstration of a 6S RNA-free core precursor and posttranslational modification
18. U snRNP assembly und transport
19. Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: Implications for spinal muscular atrophy
20. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
21. Identification of survival motor neuron as a transcriptional activator-binding protein
22. Direct interaction of SMN with dp103, a putative RNA helicase: A role for SMN in transcription regulation?
23. Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C
24. Spliceosome assembly
25. Splicing of precursors to mRNAs by the spliceosome
26. Gemin4: A novel component of the SMN complex that is found in both gems and nucleoli
27. The S.pombe protein Yab8p and a novel factor, Yip1p, share structural and functional similarity with the spinal muscular atrophy-associated proteins SMN and SIP1
28. Nucleoplasmic segregation of proteins and RNAs
29. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
30. Gel electrophoretic isolation of splicing complexes containing U1 small ribonucleoprotein particles
31. In vitro reconstitution of mammalian U2 and U5 snRNPs active in splicing: Sm proteins are functionally interchangeable and are essential for the formation of functional U2 and U5 snRNPs
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33. Internal amino acid sequence analysis of proteins separated by gel electrophoresis after tryptic digestion in polyacrylamide matrix