Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 1101-1111

  Verdone, Loredana ^a   Wu, Jiansheng ^a   Van Riper, Kristen ^a   Kacherovsky, Nataly ^a   Vogelauer, Maria ^a   Young, Elton T ^a   Grunstein, Michael ^a   Di Mauro, Ernesto ^a   Caserta, Micaela ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

ADH2; Chromatin remodeling; Histone acetylation; Saccharomyces cerevisiae; Transcriptional regulation

Indexed keywords

ALCOHOL DEHYDROGENASE; DEACETYLASE HDA1; DEACETYLASE RPD3; HISTONE; HISTONE DEACETYLASE; MESSENGER RNA; PROTEIN ADH2; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ADR1; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; GENE DISRUPTION; GENE REPRESSION; IN VIVO STUDY; KINETICS; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; SACCHAROMYCES CEREVISIAE; TATA BOX; TRANSCRIPTION REGULATION;

ACETYLATION; ACETYLTRANSFERASES; ALCOHOL DEHYDROGENASE; CHROMATIN; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONES; MODELS, GENETIC; NUCLEOSOMES; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRESSOR PROTEINS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TATA BOX; TATA-BOX BINDING PROTEIN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036500258     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.1101     Document Type: Article

References (58)

1. What does 'chromatin remodeling' mean?
2. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esalp and the ATM-related cofactor Tralp
3. Effects of histone acetylation on the equilibrium accessibility of nucleosomal DNA target sites
4. Role of histone acetylation in the assembly and modulation of chromatin structures
5. Characterization of a regulatory region upstream of the ADR2 locus of S. Cerevisiae
6. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
7. ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB
8. Esalp is an essential histone acetyltransferase required for cell cycle progression
9. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
10. Histone acetylation at promoters is differentially affected by specific activators and repressors
11. Isolation and characterization of the positive regulatory gene ADR1 from Saccharomyces cerevisiae
12. Two distinct nucleosome alterations characterize chromatin remodeling at the Saccharomyces cerevisiae ADH2 promoter
13. ADH2 expression is repressed by REG1 independently of mutations that alter the phosphorylation of the yeast transcription factor ADR1
14. Modulation of chromatin folding by histone acetylation
15. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
16. ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF
17. Histone acetyltransferase complexes stabilize SWI/SNF binding to promoter nucleosomes
18. Core histone acetylation co-maps with generalized DNase I sensitivity in the chicken β-globin chromosomal domain
19. Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction
20. Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure
21. Transcriptionally active Xenopus laevis somatic 5 S ribosomal RNA genes are packaged with hyperacetylated histone H4, whereas transcriptionally silent oocyte genes are not
22. Histone deacetylase activity of RPD3 is important for transcriptional repression in vivo
23. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
24. Chromatin-modifying and -remodeling complexes
25. Cell cycle-regulated histone acetylation required for expression of the yeast HO gene
26. Histone acetyltransferase activity of Gcn5p is required for the activation of target genes in vivo
27. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
28. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme
29. Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing ih Saccharomyces cerevisiae
30. Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer
31. Enhancement of TBP binding by activators and general transcription factors
32. Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci
33. Histone octamer transfer by a chromatin-remodeling complex
34. Protein modules that manipulate histone tails for chromatin regulation
35. Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin
36. Characterization of the yeast SWI1, SWI2 and SWI3 genes, which encode a global activator of transcription
37. A transient histone hyperacetylation signal marks nucleosomes for remodeling at the PHO8 promoter in vivo
38. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
39. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3
40. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae
41. Post-translational regulation of Adr1 activity is mediated by its DNA binding domain
42. ESA1 is a histone acetyltransferase that is essential for growth in yeast
43. The language of covalent histone modifications
44. Histone acetylation and transcriptional regulatory mechanisms
45. Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin
46. An engine for nucleosome remodeling
47. In vivo analysis of chromatin following nystatin-mediated import of active enzymes into Saccharomyces cerevisiae
48. Chromatin remodeling during Saccharomyces cerevisiae ADH2 gene activation
49. Factors affecting Saccharomyces cerevisiae ADH2 chromatin remodeling and transcription
50. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
51. ATP-dependent chromatin-remodeling complexes
52. The H3-H4 N-terminal tail domains are the primary mediators of transcription factor IIIA access to 5 S DNA within a nucleosome
53. Global histone acetylation and deacetylation in yeast
54. Nucleosome mobilization catalyzed by the yeast SWI/SNF complex
55. The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I
56. 25 Years after the nucleosome model: Chromatin modifications
57. TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast
58. Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast