Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene

International Journal of Radiation Oncology Biology Physics

Volumn 52, Issue 3, 2002, Pages 822-830

  Gupta, Anu ^a   Yang, Li Xi ^a   Chen, Ling chun ^a  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

Breast cancer; Cell cycle; Cul 4A; p53

Indexed keywords

CELLS; CLONING; DNA; IONIZING RADIATION; TUMORS;

MOCK TRANSFECTED CELLS;

GENES;

CELL PROTEIN; COMPLEMENTARY DNA; DNA; PROTEIN P53;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER GROWTH; CARCINOGENESIS; CELL CLONE; CELL CYCLE; CELL LINE; CELL SELECTION; CONTROLLED STUDY; CUL 4A GENE; DNA DAMAGE; GENE; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION INJURY; ULTRAVIOLET RADIATION;

BREAST NEOPLASMS; CELL CYCLE PROTEINS; CULLIN PROTEINS; DNA DAMAGE; FEMALE; FLOW CYTOMETRY; G2 PHASE; GENE AMPLIFICATION; HUMANS; METAPHASE; NEOPLASM PROTEINS; RADIATION TOLERANCE; TUMOR CELLS, CULTURED;

EID: 0036499063     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(01)02739-0     Document Type: Article

References (48)

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4. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha
5. A homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
6. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway
7. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
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10. Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1
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12. Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): Evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway
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15. Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer
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