Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects: Systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma

Blood

Volumn 99, Issue 5, 2002, Pages 1802-1810

  Zhang, Renliang ^a,b,c   Shen, Zhongzhou ^a,b,c   Nauseef, William M ^a,b,c   Hazen, Stanley L ^a,b,c,d  

^a Center for Cardiovascular Diagnostics   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; ESTRADIOL; HYDROXYICOSATETRAENOIC ACID; LOW DENSITY LIPOPROTEIN; MYELOPEROXIDASE; NITRITE; THIOCYANATE; TYROSINE;

ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CATALYSIS; CELL FRACTIONATION; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME DEFICIENCY; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LEUKOCYTE; LEUKOCYTE ACTIVATION; LIPID PEROXIDATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TIME SERIES ANALYSIS;

CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; ESTRADIOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LEUKOCYTES; LIPID METABOLISM; LIPID PEROXIDATION; NEUTROPHILS; NITRITES; PEROXIDASE; PLASMA; SUBSTRATE SPECIFICITY; THIOCYANATES; TYROSINE;

EID: 0036493406     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.5.1802     Document Type: Article

References (80)

1. Beyond cholesterol: Odifications of low-density lipoprotein that increase its atherogenicity
2. The role of oxidized lipoproteins in atherogenesis
3. Oxidized LDL atherogenesis
4. The oxidation of lipoproteins by monocytes-macrophages: Biochemical and biological mechanisms
5. Myeloperoxidase-generated oxidants and atherosclerosis
6. Prostaglandins, arachidonic acid, and inflammation
7. Eicosanoids in inflammation
8. Arachidonic acid metabolism
9. Leukotrienes and other products of the 5-lipoxygenase pathway: Biochemistry and relation to pathobiology in human diseases
10. Lipoxygenases and atherosclerosis: Protection versus pathogenesis
11. Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum
12. Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro
13. Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low-density lipoprotein
14. Myeloperoxidase: A key regulator of neutrophil oxidant production
15. Studies on the chlorinating activity of myeloperoxidase
16. Long-lived oxidants generated by human neutrophils: Characterization and bioactivity
17. Oxidation of chloride and thiocyanate by isolated leukocytes
18. Thiocyanate and chloride as competing substrates for myeloperoxidase
19. Estrogen binding by leukocytes during phagocytosis
20. The role of myeloperoxidase in the oxidation of biologically active polyhydroxyphenols (substituted catechols)
21. Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins
22. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite: A potential additional mechanism of nitric oxide-dependent toxicity
23. Oxidation of clozapine and ascorbate by myeloperoxidase
24. NADPH as a co-substrate for studies of the chlorinating activity of myeloperoxidase
25. Kinetics of oxidation of serotonin by myeloperoxidase compounds I and II
26. Nitric oxide is a physiological substrate for mammalian peroxidases
27. Mechanism of reaction of myeloperoxidase with nitrite
28. Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages
29. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
30. Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: Pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo
31. Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques
32. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry
33. Reactive nitrogen intermediates promote lowdensity lipoprotein oxidation in human atherosclerotic intima
34. Myeloperoxidase and protein oxidation in cystic fibrosis
35. Elevated protein carbonyls and lipid peroxidation products correlating with myeloperoxidase in tracheal aspirates from premature infants
36. Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: Characterization of pathways available to eosinophils for generating reactive nitrogen species
37. Role of myeloperoxidase in the neutrophil-induced oxidation of low-density lipoprotein as studied by myeloperoxidase-knockout mouse
38. --mediated modification of low-density lipoprotein
39. Paradoxical actions of antioxidants in the oxidation of low-density lipoprotein by peroxidases
40. p-hydroxyphenylacetaldehyde, the major product of tyrosine oxidation by the activated myeloperoxidase system, can act as an antioxidant in LDL
41. The mechanism of the hypochlorite-induced lipid peroxidation
42. Granule enzymes of polymorphonuclear neutrophils: A phylogenetic comparison
43. The proper study of mankind
44. Increased atherosclerosis in myeloperoxidase-deficient mice
45. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples
46. 2 solutions in the UV)
47. Oxidation of guaiacol by myeloperoxidase: A two-electron-oxidized guaiacol transient species as a mediator of NADPH oxidation
48. Assays for the chlorination activity of myeloperoxidase
49. 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: Potential markers for eosinophil-dependent tissue injury in vivo
50. Myeloperoxidase of the leukocyte of normal blood, I: Reaction of myeloperoxidase with hydrogen peroxide
51. Practical methods for plasma lipoprotein analysis
52. p-hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes: A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase
53. Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase
54. Pattern of inheritance in hereditary myeloperoxidase deficiency associated with the R569W missense mutation
55. Antioxidant defenses and lipid peroxidation in human blood plasma
56. Role of myeloperoxidase in the respiratory burst of human neutrophils
57. Increased respiratory burst in myeloperoxidasedeficient monocytes
58. Phagocytic activity and oxidative burst of granulocytes in persons with myeloperoxidase deficiency
59. A resolution x-ray crystal structure of the bisubstrate analogue inhibitor salicylhydroxamic acid bound to human myeloperoxidase: A model for a prereaction complex with hydrogen peroxide
60. 3-Chlorotyrosine, a specific marker for myeloperoxidase-catalyzed halogenation, is present in human atherosclerotic aorta
61. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase
62. Myeloperoxidase deficiency
63. Nitrite as a substrate and inhibitor of myeloperoxidase: Implications for nitration and hypochlorous acid production at sites of inflammation
64. Evidence for more extensive deposits of epitopes of oxidized low-density lipoprotein in aortas of young people with elevated serum thiocyanate levels: PDAY Research Group
65. Thiocyanate in smokers interferes with the Nova magnesium ion-selective electrode
66. A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: High and low serum thiocyanate groups as an indication of smoking: PDAY Research Group: Pathobiological determinants of atherosclerosis in youth
67. Eosinophil peroxidase oxidation of thiocyanate: Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system
68. Substrates and products of eosinophil peroxidase
69. Serum estrogen levels in men with acute myocardial infarction
70. Elevated oestrogen and reduced testosterone levels in the serum of male septic shock patients
71. Oestrogens as antioxidant cardioprotectants
72. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women: Heart and Estrogen/progestin Replacement Study (HERS) Research Group
73. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis
74. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
75. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
76. Consequences of total and subtotal myeloperoxidase deficiency: Risk or benefit?
77. Myeloperoxidase is an independent marker of coronary artery disease