Lipoxygenases and atherosclerosis: Protection versus pathogenesis

Free Radical Biology and Medicine

Volumn 28, Issue 12, 2000, Pages 1726-1734

  Cathcart, Martha K ^a   Folcik, Virginia A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Atherosclerosis; Cytokines; Free radical; Inflammation; Interleukin 13; Lipid oxidation; Lipoprotein oxidation; Lipoxygenase; Monocyte macrophage activation

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; CYTOKINE; FREE RADICAL; LIPID; LIPOXYGENASE;

ATHEROGENESIS; ATHEROSCLEROSIS; ENZYME ACTIVITY; LIPID OXIDATION; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; REVIEW;

SIGANUS;

EID: 0034659151     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00230-6     Document Type: Article

References (72)

1. Kuhn H., Thiele B.J. The diversity of the lipoxygenase family. Many sequence data but little information on biological significance. FEBS Lett. 449:1999;7-11.
2. Thiele B.J., Berger M., Schwarz K., Borngraber S., Kuhn H., Ostareck-Lederer A., Thiele H. Expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15- lipoxygenase in rabbits. Adv. Exp. Med. Biol. 447:1999;5-61.
3. Yla-Herttuala S. Oxidized LDL and atherogenesis. Ann. NY Acad. Sci. 874:1999;134-137.
4. Holvoet P., Collen D. Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis. Atherosclerosis. 137:(Suppl):1998;S33-S38.
5. Sparrow C.P., Parthasarathy S., Steinberg D. Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification. J. Lipid Res. 29:1988;745-753.
6. Cathcart M.K., McNally A.K., Chisolm G.M. III. Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex. J. Lipid Res. 32:1991;63-70.
7. Cathcart M.K., Li Q., Chisolm G.M. III. Lipoprotein receptor interactions are not required for monocyte oxidation of LDL. J. Lipid Res. 36:1995;1857-1865.
8. Tangirala R.K., Mol M.J., Steinberg D. Macrophage oxidative modification of low density lipoprotein occurs independently of its binding to the low density lipoprotein receptor. J. Lipid Res. 37:1996;835-843.
9. Chisolm G.M. III, Hazen S.L., Fox P.L., Cathcart M.K. The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanisms. J. Biol. Chem. 274:1999;25959-25962.
10. Cathcart M.K., Morel D.W., Chisolm G.M. III. Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. J. Leukoc. Biol. 38:1985;341-350.
11. Folcik V.A., Cathcart M.K. Assessment of 5-lipoxygenase involvement in human monocyte-mediated LDL oxidation. J. Lipid Res. 34:1993;69-79.
12. Jessup W., Darley-Usmar V., O'Leary V., Bedwell S. 5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein. Biochem. J. 278:1991;163-169.
13. Folcik V.A., Cathcart M.K. Predominance of esterified hydroperoxy-linoleic acid in human monocyte-oxidized LDL. J. Lipid Res. 35:1994;1570-1582.
14. Folcik V.A., Nivar-Aristy R.A., Krajewski L.P., Cathcart M.K. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. J. Clin. Invest. 96:1995;504-510.
15. Kuhn H., Wiesner R., Lankin V.Z., Nekrasov A., Alder L., Schewe T. Analysis of the stereochemistry of lipoxygenase-derived hydroxypolyenoic fatty acids by means of chiral phase high-pressure liquid chromatography. Anal. Biochem. 160:1987;24-34.
16. Conrad D.J., Kuhn H., Mulkins M., Highland E., Sigal E. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc. Natl. Acad. Sci. USA. 89:1992;217-221.
17. Nassar G.M., Morrow J.D., Roberts L.J.D., Lakkis F.G., Badr K.F. Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J. Biol. Chem. 269:1994;27631-27634.
18. McNally A.K., Chisolm G.M.D., Morel D.W., Cathcart M.K. Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway. J. Immunol. 145:1990;254-259.
19. Rankin S.M., Parthasarathy S., Steinberg D. Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. J. Lipid Res. 32:1991;449-456.
20. Li Q., Cathcart M.K. Selective inhibition of cytosolic phospholipase A2 in activated human monocytes. Regulation of superoxide anion production and low density lipoprotein oxidation. J. Biol. Chem. 272:1997;2404-2411.
21. Sparrow C.P., Olszewski J. Cellular oxidative modification of low density lipoprotein does not require lipoxygenases. Proc. Natl. Acad. Sci. USA. 89:1992;128-131.
22. Sendobry S.M., Cornicelli J.A., Welch K., Bocan T., Tait B., Trivedi B.K., Colbry N., Dyer R.D., Feinmark S.J., Daugherty A. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br. J. Pharmacol. 120:1997;1199-1206.
23. Sigari F., Lee C., Witztum J.L., Reaven P.D. Fibroblasts that overexpress 15-lipoxygenase generate bioactive and minimally modified LDL. Arterioscler. Thromb. Vasc. Biol. 17:1997;3639-3645.
24. Sun D., Funk C.D. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J. Biol. Chem. 271:1996;24055-24062.
25. Folcik V.A., Aamir R., Cathcart M.K. Cytokine modulation of LDL oxidation by activated human monocytes. Arterioscler. Thromb. Vasc. Biol. 17:1997;1954-1961.
26. Brinckmann R., Schnurr K., Heydeck D., Rosenbach T., Kolde G., Kuhn H. Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme. Blood. 91:1998;64-74.
27. Huh H.Y., Pearce S.F., Yesner L.M., Schindler J.L., Silverstein R.L. Regulated expression of CD36 during monocyte-to-macrophage differentiation potential role of CD36 in foam cell formation . Blood. 87:1996;2020-2028.
28. Huang J.T., Welch J.S., Ricote M., Binder C.J., Willson T.M., Kelly C., Witztum J.L., Funk C.D., Conrad D., Glass C.K. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature. 400:1999;378-382.
29. Nagy L., Tontonoz P., Alvarez J.G., Chen H., Evans R.M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 93:1998;229-240.
30. Tontonoz P., Nagy L., Alvarez J.G., Thomazy V.A., Evans R.M. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 93:1998;241-252.
31. Chinetti G., Griglio S., Antonucci M., Torra I.P., Delerive P., Majd Z., Fruchart J.C., Chapman J., Najib J., Staels B. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem. 273:1998;25573-25580.
32. Marx N., Sukhova G., Murphy C., Libby P., Plutzky J. Macrophages in human atheroma contain PPARgamma differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in monocyte-macrophages in vitro . Am. J. Pathol. 153:1998;17-23.
33. Febbraio M., Abumrad N.A., Hajjar D.P., Sharma K., Cheng W., Pearce S.F., Silverstein R.L. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J. Biol. Chem. 274:1999;19055-19062.
34. Brezinski M.E., Serhan C.N. Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils agonist-induced deacylation and transformation of stored hydroxyeicosanoids . Proc. Natl. Acad. Sci. USA. 87:1990;6248-6252.
35. Legrand A.B., Lawson J.A., Meyrick B.O., Blair I.A., Oates J.A. Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway. J. Biol. Chem. 266:1991;7570-7577.
36. Chaitidis P., Schewe T., Sutherland M., Kuhn H., Nigam S. 15-Lipoxygenation of phospholipids may precede the sn-2 cleavage by phospholipases A2 reaction specificities of secretory and cytosolic phospholipases A2 towards native and 15-lipoxygenated arachidonoyl phospholipids . FEBS Lett. 434:1998;437-441.
37. Rapoport S.M., Schewe T. The maturational breakdown of mitochondria in reticulocytes. Biochim. Biophys. Acta. 864:1986;471-495.
38. Brinckmann R., Kuhn H. Regulation of 15-lipoxygenase expression by cytokines. Adv. Exp. Med. Biol. 1997;599-604.
39. Yla-Herttuala S., Rosenfeld M.E., Parthasarathy S., Glass C.K., Sigal E., Witztum J.L., Steinberg D. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 87:1990;6959-6963.
40. Yla-Herttuala S., Rosenfeld M.E., Parthasarathy S., Sigal E., Sarkioja T., Witztum J.L., Steinberg D. Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts. J. Clin. Invest. 87:1991;1146-1152.
41. Glavind J., Hartmann S., Clemmesen J., Jessen K.E., Dam H. Role of lipoperoxidases in human pathology, Part 2 (The presence of peroxidzed lipids in the atherosclerotic aorta.). Acta Pathol. Microbiol. Scand. 30:1952;1-9.
42. Harland W.A., Gilbert J.D., Steel G., Brooks C.J. Lipids of human atheroma. 5. The occurrence of a new group of polar sterol esters in various stages of human atherosclerosis. Atherosclerosis. 13:1971;239-246.
43. Brooks C.J., Steel G., Gilbert J.D., Harland W.A. Lipids of human atheroma. 4. Characterisation of a new group of polar sterol esters from human atherosclerotic plaques. Atherosclerosis. 13:1971;223-237.
44. Kuhn H., Belkner J., Zaiss S., Fahrenklemper T., Wohlfeil S. Involvement of 15-lipoxygenase in early stages of atherogenesis. J. Exp. Med. 179:1994;1903-1911.
45. Kuhn H., Heydeck D., Hugou I., Gniwotta C. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. J. Clin. Invest. 99:1997;888-893.
46. Bocan T.M., Rosebury W.S., Mueller S.B., Kuchera S., Welch K., Daugherty A., Cornicelli J.A. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis. 136:1998;203-216.
47. Cornicelli, J. A.; Trivedi, B. K. 15-Lipoxygenase and its inhibition: a novel therapeutic target for vascular disease. Curr. Pharm. Des. 5:11-20; 1999.
48. Cyrus T., Witztum J.L., Rader D.J., Tangirala R., Fazio S., Linton M.F., Funk C.D. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. J. Clin. Invest. 103:1999;1597-1604.
49. Shen J., Herderick E., Cornhill J.F., Zsigmond E., Kim H.S., Kuhn H., Guevara N.V., Chan L. Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development. J. Clin. Invest. 98:1996;2201-2208.
50. Kuhn H., Chan L. The role of 15-lipoxygenase in atherogenesis pro- and antiatherogenic actions . Curr. Opin. Lipidol. 8:1997;111-117.
51. Van Heek M., Schmitt D., Toren P., Cathcart M.K., DiCorleto P.E. Cholesteryl hydroperoxyoctadecadienoate from oxidized low density lipoprotein inactivates platelet-derived growth factor. J. Biol. Chem. 273:1998;19405-19410.
52. Auge N., Santanam N., Mori N., Keshava C., Parthasarathy S. Uptake of 13-hydroperoxylinoleic acid by cultured cells. Arterioscler. Thromb. Vasc. Biol. 19:1999;925-931.
53. Glasgow W.C., Hui R., Everhart A.L., Jayawickreme S.P., Angerman-Stewart J., Han B.B., Eling T.E. The linoleic acid metabolite, (13S)-hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes. J. Biol. Chem. 272:1997;19269-19276.
54. Khan, B. V.; Parthasarathy, S. S.; Alexander, R. W.; Medford, R. M. Modified low density lipoprotein and its constituents augment cytokine- activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J. Clin. Invest. 95:1262-1270; 1995.
55. Sultana C., Shen Y., Rattan V., Kalra V.K. Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL-60 cells is linked to protein kinase C activation. J. Cell Physiol. 167:1996;477-487.
56. Rao G.N., Alexander R.W., Runge M.S. Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. J. Clin. Invest. 96:1995;842-847.
57. Sandstrom P.A., Pardi D., Tebbey P.W., Dudek R.W., Terrian D.M., Folks T.M., Buttke T.M. Lipid hydroperoxide-induced apoptosis lack of inhibition by Bcl-2 over-expression . FEBS Lett. 365:1995;66-70.
58. Ramasamy S., Lipke D.W., Boissonneault G.A., Guo H., Hennig B. Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. Atherosclerosis. 120:1996;199-208.
59. Henricks P.A., Engels F., van der Vliet H., Nijkamp F.P. 9- and 13-hydroxy-linoleic acid possess chemotactic activity for bovine and human polymorphonuclear leukocytes. Prostaglandins. 41:1991;21-27.
60. Kang L.T., Phillips T.M., Vanderhoek J.Y. Novel membrane target proteins for lipoxygenase-derived mono(S)hydroxy fatty acids. Biochim. Biophys. Acta. 1438:1999;388-398.
61. Fujimoto Y., Sumiya T., Tsunomori M., Nishida H., Sakuma S., Fujita T. Effect of 13-hydroperoxy-9,11-octadecadienoic acid (13-HPODE) on arachidonic acid metabolism in rabbit platelets. Int. J. Biochem. 26:1994;127-131.
62. Simon T.C., Makheja A.N., Bailey J.M. The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-HODE. Thromb. Res. 55:1989;171-178.
63. Coene M.C., Bult H., Claeys M., Laekeman G.M., Herman A.G. Inhibition of rabbit platelet activation by lipoxygenase products of arachidonic and linoleic acid. Thromb. Res. 42:1986;205-214.
64. Krey G., Braissant O., L'Horset F., Kalkhoven E., Perroud M., Parker M.G., Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator- dependent receptor ligand assay. Mol. Endocrinol. 11:1997;779-791.
65. Roy B., Cathcart M.K. Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes. J. Biol. Chem. 273:1998;32023-32029.
66. Kelavkar U., Wang S., Montero A., Murtagh J., Shah K., Badr K. Human 15-lipoxygenase gene promoter analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes . Mol. Biol. Rep. 25:1998;173-182.
67. Watson A., Doherty F.J. Calcium promotes membrane association of reticulocyte 15-lipoxygenase. Biochem. J. 298:1994;377-383.
68. Lankin V.Z., Kuhn H., Hiebsch C., Schewe T., Rapoport S.M., Tikhaze A.K., Gordeeva N.T. On the nature of the stimulation of the lipoxygenase from rabbit reticulocytes by biological membranes. Biomed. Biochim. Acta. 44:1985;655-664.
69. Ostareck D.H., Ostareck-Lederer A., Wilm M., Thiele B.J., Mann M., Hentze M.W. mRNA silencing in erythroid differentiation hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end . Cell. 89:1997;597-606.
70. Thiele B.J., Andree H., Hohne M., Rapoport S.M. Lipoxygenase mRNA in rabbit reticulocytes. Its isolation, characterization and translational repression. Eur. J. Biochem. 129:1982;133-141.
71. O'Prey J., Harrison P.R. Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer. Nucleic Acids Res. 23:1995;3664-3672.
72. Dixon R.A., Diehl R.E., Opas E., Rands E., Vickers P.J., Evans J.F., Gillard J.W., Miller D.K. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature. 343:1990;282-284.