Neuroprotection produced by the NAALADase inhibitor 2-PMPA in rat cerebellar neurons

European Journal of Pharmacology

Volumn 402, Issue 1-2, 2000, Pages 31-37

  Tortella, Frank C ^a   Lin, Yu ^a   Ved, Haresh ^a   Slusher, Barbara S ^b   Dave, Jitendra R ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

(Rat); NAALADase inhibition (N acetylated linked acidic dipeptidase); Neuroprotection; Stroke

Indexed keywords

2 (PHOSPHONOMETHYL)PENTANEDIOIC ACID; ENZYME INHIBITOR; N ACETYLASPARTYLGLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN PROTECTION; CELL HYPOXIA; DRUG EFFICACY; DRUG POTENCY; EMBRYO; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ANIMALS; CARBOXYPEPTIDASES; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMIC ACID; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; VERATRIDINE;

EID: 0034683184     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00519-7     Document Type: Article

References (17)

1. Blakely R., Coyle J. The neurobiology of N-acetylaspartylglutamate. Int. Rev. Neurobiol. 30:1988;39-100.
2. Cai N.S., Olkowaski J.L., Jackson P.F., Slusher B.S. Binding of the NAALADase inhibitor 2-PMPA to brain membranes exhibiting two-site kinetics. Soc. Neurosci. Abstr. 24:1998;582.
3. Coyle J.T. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol. Dis. 4(304):1997;231-238.
4. Dave J.R., Koenig M.L., Tortella F.C., Pieringer R.A., Doctor B.P., Ved H.S. Dodecylglycerol provides partial protection against glutamate toxicity in neuronal cultures derived from different regions of embryonic rat brain. Mol. Chem. Neuropathol. 30:1997;1-13.
5. Hess S.D., Pasieczny R., Rao S.P., Jachee C., Varney M.A., Johnson E.C. Activity of N-acetylaspartylglutamate at human recombinant glutamate receptors. Soc. Neurosci. Abstr. 25:1999;975.
6. Jackson P.F., Cole D.C., Slusher B.S., Stetz S.L., Ross L.E., Donznati B.A., Trainor D.A. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptide N-acetyl-α-linked acidic dipeptidase. J. Med. Chem. 39:1996;619-622.
7. Luthi-Carter R., Berger U.V., Barczak A.K., Enna M., Coyle J.T. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3215-3220.
8. Norton W.T., Aquino D.A., Hozumi I., Chiu F.C., Brosnan C.F. Quantitative aspects of reactive gliosis: a review. Neurochem. Res. 17:1992;877-885.
9. Olkowski J.L., Thomas A.G., Slusher B.S. Neuroprotection afforded by NAALADase inhibition requires glial cells. Soc. Neurosci. Abstr. 24:1998;582.
10. Orlando L.R., Luthi-Carter R., Standaert D.G., Coyle J.T., Penney J.B., Young A.B. N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo. Neurosci. Lett. 236:1997;91-94.
11. Pin J.P., Duvoisin R. Review: neurotransmitter receptors I: the metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
12. Slusher B.S., Robinson M.B., Tsai G., Simmons M.L., Richards S.S., Coyle J.T. Rat brain N-acetylated alpha-linked acidic dipeptidase activity: purification and immunologic characterization. J. Biol. Chem. 265(34):1990;21297-21301.
13. Slusher B., Varnov J., Thomas A., Hurn P., Harukuni I., Bhardwaj A., Traystman R., Robinson M., Britton P., May Lu X.-C., Tortella F., Wozniak K., Yudkoff M., Jackson P. Reduction of extracellular glutamate via NAALADase inhibition is neuroprotective. Nat. Med. 5(12):1999;1396-1402.
14. Tortella F., Williams A., Slusher B., Lu M. EEG studies on 2-PMPA, an upstream modulator of hyperglutamatergic activity and neuroprotectant, in rats. Soc. Neurosci. Abstr. 25:1999;2230.
15. Wroblewska B., Neale J.H., Bzdega T., Lea P.M., Sarvey J.M. Antagonist effects of β-NAAG on mGluR3 receptor. Soc. Neurosci. Abstr. 24:1998;585.
16. Yourick D.L., Koenig M., Long J.B. Metabotropic glutamate receptors do not mediate N-acetylaspartylglutamate (NAAG) protection of spinal cord cultures from NMDA-induced cell death. Soc. Neurosci. Abstr. 25:1999;841.
17. Ved H.S., Koenig M.L., Dave J.R., Doctor B.P. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. NeuroReport. 8(4):1997;963-968.