Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes

Ageing Research Reviews

Volumn 1, Issue 1, 2002, Pages 1-15

  Stern, David M ^a   Yan, Shi Du ^b   Yan, Shi Fang ^b   Schmidt, Ann Marie ^b  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Atherosclerosis; Glycation; Macrovasculature; Periodontium; Vascular permeability; Wound repair

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; ANTIOXIDANT; APOLIPOPROTEIN E; CALGRANULIN; DIPHENYLIODONIUM SALT; GELATINASE B; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN F(AB')2 FRAGMENT; PLATELET DERIVED GROWTH FACTOR B; RECEPTOR SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOBARBITURIC ACID; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN RECEPTOR;

AGED; ATHEROSCLEROSIS; BETA SHEET; BINDING SITE; BLOOD VESSEL PERMEABILITY; CANCER INVASION; CELL INVASION; CELL MIGRATION; CHEMOTAXIS; DELAYED HYPERSENSITIVITY; DIABETES MELLITUS; ENDOTHELIUM LESION; ENZYME ACTIVITY; GLIOMA CELL; HUMAN; LEWIS CARCINOMA; LIGAND BINDING; NONHUMAN; OXIDATIVE STRESS; PATHOLOGY; PERIODONTAL DISEASE; PHAGOCYTE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; REVIEW; SIGNAL TRANSDUCTION; VASCULAR DISEASE; WOUND HEALING; ANIMAL; METABOLISM; NEUROFILAMENT;

MURINAE;

ANIMALS; DIABETES COMPLICATIONS; DIABETES MELLITUS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; IMMUNOGLOBULINS; NEUROFIBRILS; RECEPTORS, IMMUNOLOGIC;

EID: 0036479827     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00366-9     Document Type: Review

References (51)

1. Araki N., Higashi T., Mori T., Shybayama R., Kawabe Y., Kodama T., Takahashi K., Shichiri M., Horiuchi S. Macrophage scavenger receptor mediates the endocytic uptake and degradation of AGEs of the Maillard reaction. Eur. J. Biochem. 227:1995;408-415.
2. Baynes J., Thorpe S. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 48:1996;1-9.
3. Brownlee M., Vlassara H., Kooney A., Ulrich P., Cerami A. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science. 232:1986;1629-1632.
4. Brett J., Schmidt A.-M., Zou Y.-S., Yan S.-D., Weidman E., Pinsky D., Neeper M., Przysiecki M., Shaw A., Migheli A., Stern D. Tissue distribution of the receptor for advanced glycation endproducts (RAGE): expression in smooth muscle, cardiac myocytes, and neural tissue in addition to the vasculature. Am. J. Pathol. 143:1993;1699-1712.
5. Bucciarelli L., Qu W., Lu Y., Wendt T., Goova M., Baker S., Hwang Y., Stern D., Schmidt A.-M. Blockade of RAGE suppresses progression of established atherosclerotic lesions in apoE null mice with type 1 diabetes. Circulation (Abstract). 102:(Suppl II):2001;1128.
6. Castano E.M., Prelli F., Soto C., Beavis R., Matsubara E., Shoji M., Frangione B. The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Proc. Natl. Acad. Sci. USA. 84:1987;5991-5994.
7. Deora A., Win T., Vanhaesebroeck B., Lander H. A redox-triggered Ras-effector interaction: recruitment of phosphatidylinositol 3'-kinase to Ras by redox stress. J. Biol. Chem. 273:1998;29923-29928.
8. Donato R. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim. Biophys. Acta. 1450:1999;191-231.
9. Ehrlich H. The physiology of wound healing. A summary of normal and abnormal wound healing processes. Adv. Wound Care. 11:1998;326-328.
10. Fages C., Nolo R., Huttunen H., Eskelinen E., Rauvala H. Regulation of cell migration by amphoterin. J. Cell. Sci. 113:2001;611-620.
11. Federoff H., Lawrence D., Brownlee M. Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth. Diabetes. 42:1993;509-513.
12. Geczy C. Regulation and proinflammatory properties of the chemotactic protein, CP-10. Biochim. Biophys. Acta. 1313:1996;246-252.
13. Goova M., Li J., Kislinger T., Qu W., Lu Y., Bucciarelli L., Nowygrod S., Wolf B., Yan S-F., Stern D., Schmidt A-M. Bockade of RAGE restores effective wound healing in diabetic mice. Am. J. Pathol. 159:2001;513-525.
14. Hammes H., Weiss A., Hess S., Araki N., Horiuchi S., Brownlee M., Preissner K. Modification of vitronectin by advanced glycation alters functional properties in vitro and in the diabetic retina. Lab. Invest. 75:1996;325-338.
15. Herold K., Ziang H.-P., Liu E., Schmidt A.-M., Stern D., Yan S.-D. Prevention of recurrent diabetes by blockade of RAGE. Diabetes. 50:2001;A33. (Abstract).
16. Hofmann M., Drury S., Caifeng F., Qu W., Lu Y., Avila C., Kambhan N., Slattery T., McClary J., Nagashima M., Morser J., Stern D., Schmidt A.-M. RAGE mediates a novel proinflammatory axis: the cell surface receptor for S100/calgranulin polypeptides. Cell. 97:1999;889-901.
17. Hori O., Brett J., Nagashima M., Nitecki D., Morser J., Stern D.M., Schmidt A.M. RAGE is a cellular binding site for amphoterin: mediation of neurite outgrowth and co-expression of RAGE and amphoterin in the developing nervous system. J. Biol. Chem. 270:1995;25752-25761.
18. Huang J., Guh J., Chen H., Hung W., Lai Y., Chuang L. Role of RAGE and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells. J. Cell. Biochem. 81:2001;102-113.
19. Huttunen H., Fages C., Rauvala H. RAGE-mediated neurite outgrowth and activation of NF-kB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J. Biol. Chem. 274:1999;19919-19924.
20. Kawahara N., Tanaka T., Yokomizo A., Nanari H., Ono M., Wada M., Kohno K., Takenaka K., Sugimachi K., Kuwano M. Enhanced coexpression of thioredoxin and HMG1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin. Cancer Res. 56:1996;5330-5333.
21. Kerkhoff C., Klempf M., Sorg C. Novel insights into structure and function of MRP8 and MRP14. Biochim. Biophys. Acta. 1448:1998;200-211.
22. Kislinger T., Fu C., Qu W., Yan S.-D., Hofmann M., Yan S.-F., Pischetstrieder M., Stern D., Schmidt A.-M. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for RAGE that activate cell signalling pathways and modulate gene expression. J. Biol. Chem. 274:1999;31740-31749.
23. Kislinger T., Tanji N., Wendt T., Qu W., Lu Y., Ferran L., Taguchi A., Olson K., Bucciarelli L., Goova M., Hofmann M., Cataldegirmen G., D'Agati V., Pischetstrieder M., Stern D., Schmidt A.-M. RAGE mediates inflammation and enhanced expression of tissue factor in the vasculature of diabetic apolipoprotein E null mice. Atheroscl. Thromb. Vasc. Biol. 21:2001;905-910.
24. Lalla E., Lamster I., Feit M., Huang L., Spessot A., Qu W., Kislinger T., Lu Y., Stern D., Schmidt A.-M. Blockade of RAGE suppresses periodontits- associated alveolar bone loss in diabetic mice. J. Clin. Invest. 105:2000;1117-1124.
25. Lander H.M., Tauras J.M., Ogiste J.S., Hori O., Moss R.A., Schmidt A.M. Activation of the Receptor for Advanced Glycation Endproducts triggers a p21ras-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J. Biol. Chem. 272:1997;17810-17814.
26. Li J., Qu W., Schmidt A.-M. Sp1 binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells. J. Biol. Chem. 273:1998;30870-30878.
27. Lue L-F., Walker D., Brachova L., Rogers J., Shen Y., Schmidt A-M., Stern D.M., Yan S-D. Involvement of RAGE-microglial interactions in Alzheimer's disease: in vivo and in vitro studies. Exptl. Neurology. 171:2001;29-45.
28. Neeper M., Schmidt A.M., Brett J., Yan S.D., Wang F., Pan Y.C., Elliston K., Stern D.M., Shaw A. Cloning and expression of RAGE: a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 267:1992;14998-15004.
29. Nishikawa T., Edelstein D., Du X.-L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M., Beebe D., Oates P., Hammes H.-P., Giardino I., Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage. Nature. 404:2000;787-790.
30. Park L., Raman K., Lee K., Lu Y., Ferran L., Chow W.-S., Stern D., Schmidt A.-M. Suppression of accelerated diabetic atherosclerosis by soluble receptor for AGE (sRAGE). Nat. Med. 4:1998;1025-1031.
31. Reddy S., Bichler J., Wells-Knecht K., Thorpe S., Baynes J. Carboxymethyllysine is a dominant AGE antigen in tissue proteins. Biochemistry. 34:1995;10872-10878.
32. Schmidt A.-M., Yan S.-D., Stern D. The biology of RAGE and its ligands. Biochim. Biophys. Acta. 1498:2000;99-111.
33. Schmidt A.M., Vianna M., Gerlach M., Brett J., Ryan J., Kao J., Esposito C., Hegarty H., Hurley W., Clauss M., Wang F., Pan Y.C., Tsang T.C., Stern D.M. Isolation and characterization of binding proteins for advanced glycosylation endproducts from lung tissue which are present on the endothelial cell surface. J. Biol. Chem. 267:1992;14987-14997.
34. Schmidt A.M., Yan S.-D., Brett J., Mora R., Nowygrod R., Stern D.M. Regulation of human mononuclear phagocyte migration by cell surface binding proteins for AGEs. J. Clin. Invest. 91:1993;2155-2168.
35. Smith M.A., Taneda S., Richey P., Miyata S., Yan S.D., Stern D., Sayre L.M., Monnier V.M., Perry G. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc. Natl. Acad. Sci. USA. 91:1994;5710-5714.
36. Taguchi A., DelToro G., Canet A., Lee D., Tanji N., Lu Y., Ingram M., Lalla E., Hofmann M., Fu J., Kislinger T., Lu A., Stern D.M., Schmidt A.-M. Blockade of RAGE/amphoterin suppresses tumor growth and metastases. Nature. 405:2000;354-360.
37. The Diabetes Control and Complications Trial Research Group. The effect of intensive therapy of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New Engl. J. Med. 329:1993;977-986.
38. The Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. New Engl. J. Med. 342:2000;381-389.
39. Thornalley P. Cell activation by glycated proteins. AGE receptors, receptor recognition factors and function classification of AGEs. Cell. Mol. Biol. (Noisy-le-grand). 44:1998;1013-1023.
40. Vitek M., Bhattacharya K., Vlassara H., Bucala R., Manogue K., Cerami A. AGEs contribute to amyloidosis in Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 91:1994;4766-4770.
41. Vlassara H., Bucala R., Striker L. Pathogenic effects of AGEs: biochemical, biologic and clinical implications for diabetes and aging. Lab. Invest. 70:1994;138-151.
42. Wautier J.L., Wautier M.P., Schmidt A.M., Anderson G.M., Zoukourian C., Capron L., Chappey O., Yan S.D., Brett J., Guillausseau P.J., Stern D. AGEs on the surface of diabetic red cells bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications. Proc. Natl. Acad. Sci. 91:1994;7742-7746.
43. Wautier J.L., Zoukourian C., Chappey O., Wautier M.P., Guillausseau P.J., Cao R., Hori O., Stern D., Schmidt A.M. Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy: soluble RAGE blocks hyperpermeability. J. Clin. Invest. 97:1996;238-243.
44. Wautier M.-P., Chappey O., Corda S., Stern D., Schmidt A.-M., Wautier J.-L. Activation of NADPH oxidase by AGEs links oxidant stress to altered gene expression via RAGE. Am. J. Physiol. 280:2001;E685-E694.
45. Williamson J., Chang K., Tilton R., Prater C., Jeffrey J., Weigel C., Sherman W. Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozotocin-induced diabetes. Diabetes. 36:1987;813-821.
46. Xiang Y., Wang D., Tanaka M., Suzuki M., Kiyokawa E., Igarashi H., Naito Y., Shen Q., Sugimura H. Expression of HMG1 mRNA in human gastrointestinal adenocarcinoma and corresponding noncancerous mucosa. Int. J. Cancer. 74:1997;1-6.
47. Yan S.-D., Chen X., Schmidt A.-M., Brett J., Godman G., Zou Y.-S., Scott C., Caputo C., Frappier T., Smith M., Perry G., Yen S.-H., Stern D.M. Glycated tau protein in Alzheimer's disease: a mechanism for induction of oxidant stress. Proc. Natl. Acad. Sci. USA. 91:1994;7787-7791.
48. Yan S.-D., Chen X., Chen M., Zhu H., Roher A., Slattery T., Zhao L., Nagashima M., Morser J., Migheli A., Nawroth P., Stern D.M., Schmidt A.-M. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature. 382:1996;685-691.
49. Yan S.-D., Zhu H., Zhu A., Golabek A., Roher A., Yu J., Soto C., Schmidt A.-M., Stern D.M., Kindy M. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat. Med. 6:2000;643-651.
50. Yeh C., Surgis L., Haidacher J., Zhang X., Sherwood S., Bjercke R., Juhasz O., Crow M., Tilton R., Denner L. Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated NF-kB transcriptional activation and cytokine secretion. Diabetes. 50:2000;1495-1504.
51. Zhou Z.-M., Marso S., Schmidt A.-M., Stern D., Qu W., Forudi F., Wang K., Lincoff A., Topol E. Blockade of RAGE suppresses neointimal formation in a diabetic rat carotid injury model. Circulation (Abstract). 102:(Suppl. II):2000;1202.