Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade

Journal of Cell Science

Volumn 115, Issue 3, 2002, Pages 531-541

  Wiggan, O'Neil ^a   Hamel, Paul A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Dishevelled; Focal adhesion; Frizzled; JNK; Pax3; Wnt signaling

Indexed keywords

ACTIN; CELL PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX3; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CELL AGGREGATION; CELL FRACTIONATION; CELL FUNCTION; CELL MOTION; CELL NUCLEUS; CELL POLARITY; CELL STRUCTURE; CONTROLLED STUDY; CYTOLOGY; CYTOPLASM; CYTOSKELETON; DEVELOPMENTAL DISORDER; EPITHELIUM CELL; FOCAL ADHESION; GASTRULATION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MESENCHYME CELL; MOLECULAR BIOLOGY; MORPHOGENESIS; MOUSE; MULTIGENE FAMILY; NEURULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOVIRIDAE; ANIMALS; CELL AGGREGATION; CELL MOVEMENT; CELL POLARITY; CELL SIZE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FOCAL ADHESIONS; FRIZZLED RECEPTORS; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOSARCOMA; PAIRED BOX TRANSCRIPTION FACTORS; PHOSPHOPROTEINS; PROTEINS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VINCULIN; WNT PROTEINS; ZEBRAFISH PROTEINS;

MAMMALIA;

EID: 0036473410     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. A model for development and evolution of complex morphological structures
2. Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling
3. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
4. An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome
5. Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration
6. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
7. Signaling specificity by Frizzled receptors in Drosophila
8. The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex
9. Towards a cellular and molecular understanding of neurulation
10. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
11. Pax genes and organogenesis
12. Neural tube closure in Xenopus laevis involves medial migration, directed protrusive activity, cell intercalation and convergent extension
13. Cellular mechanism underlying neural convergent extension in Xenopus laevis embryos
14. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
15. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
16. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
17. Morphogenesis of the neural plate and tube
18. Convergent extension by cell interaction during gastrulation of Xenopus laevis
19. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
20. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
21. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells
22. Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
23. JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila
24. Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates
25. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
26. JNK signaling and morphogenesis in Drosophila
27. Roles of the JNK signaling pathway in Drosophila morphogenesis
28. Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts
29. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
30. Focal adhesions: A nexus for intracellular signaling and cytoskeletal dynamics
31. Cell motility driving mediolateral intercalation in explants of Xenopus laevis
32. A role for wnts in morpho-genesis and tissue polarity
33. Xwnt11 is a target of Xenopus Brachyury: Regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway
34. Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene
35. Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesis
36. Molecular genetic studies of Wnt signaling in the mouse
37. Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: Parallel forces elongating the body axis
38. Dishevelled controls cell polarity during Xenopus gastrulation
39. Pax3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion
40. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
41. GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1
42. Thorax closure in Drosophila: Involvement of Fos and the JNK pathway