메뉴 건너뛰기




Volumn 63, Issue SUPPL. 13, 2002, Pages 5-11

Quetiapine: Preclinical studies, pharmacokinetics, drug interactions, and dosing

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; DIBENZOTHIAZEPINE DERIVATIVE; DOPAMINE; DOPAMINE 2 RECEPTOR; HISTAMINE; NEUROTENSIN; NEUROTRANSMITTER RECEPTOR; PROLACTIN; QUETIAPINE; SEROTONIN;

EID: 0036459983     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (152)

References (59)
  • 1
    • 0000535420 scopus 로고    scopus 로고
    • Preclinical profile of Seroquel (quetiapine): An atypical antipsychotic with clozapine-like pharmacology
    • Holliday SG, Ancill RJ, MacEwen GW, eds. New York, NY: John Wiley & Sons
    • Goldstein J. Preclinical profile of Seroquel (quetiapine): An atypical antipsychotic with clozapine-like pharmacology. In: Holliday SG, Ancill RJ, MacEwen GW, eds. Schizophrenia: Breaking Down the Barriers. New York, NY: John Wiley & Sons; 1996:177-208
    • (1996) Schizophrenia: Breaking Down the Barriers , pp. 177-208
    • Goldstein, J.1
  • 2
    • 0034711425 scopus 로고    scopus 로고
    • Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compounds
    • Richelson E, Souder T. Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compounds. Life Sci 2000;68:29-39
    • (2000) Life Sci , vol.68 , pp. 29-39
    • Richelson, E.1    Souder, T.2
  • 3
    • 0027218797 scopus 로고
    • Seroquel: Behavioral effects in conventional and novel tests for atypical antipsychotic drug
    • Migler BM, Warawa EJ, Malick JB. Seroquel: Behavioral effects in conventional and novel tests for atypical antipsychotic drug. Psychopharmacology (Berl) 1993;112:299-307
    • (1993) Psychopharmacology (Berl) , vol.112 , pp. 299-307
    • Migler, B.M.1    Warawa, E.J.2    Malick, J.B.3
  • 4
    • 0032937396 scopus 로고    scopus 로고
    • Quetiapine fumarate (seroquel): A new atypical antipsychotic
    • Goldstein J. Quetiapine fumarate (seroquel): A new atypical antipsychotic. Drugs Today 1999;35:193-210
    • (1999) Drugs Today , vol.35 , pp. 193-210
    • Goldstein, J.1
  • 5
    • 0028335509 scopus 로고
    • Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: Similarities to clozapine
    • Swerdlow NR, Zisook D, Taaid N. Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: Similarities to clozapine. Psychopharmacology (Berl) 1994;114:675-678
    • (1994) Psychopharmacology (Berl) , vol.114 , pp. 675-678
    • Swerdlow, N.R.1    Zisook, D.2    Taaid, N.3
  • 6
    • 0030426257 scopus 로고    scopus 로고
    • Seroquel restores sensorimotor gating in phencyclidine-treated rats
    • Swerdlow NR, Bakshi V, Geyer MA. Seroquel restores sensorimotor gating in phencyclidine-treated rats. J Pharmacol Exp Ther 1996;279: 1290-1299
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1290-1299
    • Swerdlow, N.R.1    Bakshi, V.2    Geyer, M.A.3
  • 7
    • 0031759855 scopus 로고    scopus 로고
    • Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats
    • Swerdlow NR, Bakshi V, Waikar M, et al. Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats. Psychopharmacology (Berl) 1998;140:75-80
    • (1998) Psychopharmacology (Berl) , vol.140 , pp. 75-80
    • Swerdlow, N.R.1    Bakshi, V.2    Waikar, M.3
  • 8
    • 17344395207 scopus 로고    scopus 로고
    • Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine
    • Bakshi VP, Swerdlow NR, Braff DL, et al. Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine. Biol Psychiatry 1998;43:436-445
    • (1998) Biol Psychiatry , vol.43 , pp. 436-445
    • Bakshi, V.P.1    Swerdlow, N.R.2    Braff, D.L.3
  • 9
    • 0035863237 scopus 로고    scopus 로고
    • Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: Evidence from animal models of sensorimotor gating
    • Binder EB, Kinkead B, Owens MJ, et al. Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: Evidence from animal models of sensorimotor gating. J Neurosci 2001;21:601-608
    • (2001) J Neurosci , vol.21 , pp. 601-608
    • Binder, E.B.1    Kinkead, B.2    Owens, M.J.3
  • 10
    • 0030272376 scopus 로고    scopus 로고
    • Activity of "Seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: A comparison with clozapine
    • Ellenbroek BA, Lubbers LJ, Cools AR. Activity of "Seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: A comparison with clozapine. Neuropsychopharmacology 1996;15: 406-416
    • (1996) Neuropsychopharmacology , vol.15 , pp. 406-416
    • Ellenbroek, B.A.1    Lubbers, L.J.2    Cools, A.R.3
  • 11
    • 0027201688 scopus 로고
    • Seroquel: Electrophysiological profile of a potential atypical antipsychotic
    • Goldstein JM, Litwin LC, Sutton EB, et al. Seroquel: Electrophysiological profile of a potential atypical antipsychotic. Psychopharmacology (Berl) 1993;112:293-298
    • (1993) Psychopharmacology (Berl) , vol.112 , pp. 293-298
    • Goldstein, J.M.1    Litwin, L.C.2    Sutton, E.B.3
  • 12
    • 0034055690 scopus 로고    scopus 로고
    • Serotonin model of schizophrenia: Emerging role of glutamate mechanisms
    • Aghajanian GK, Marek GJ. Serotonin model of schizophrenia: Emerging role of glutamate mechanisms. Brain Res Brain Res Rev 2000;31:302-312
    • (2000) Brain Res Brain Res Rev , vol.31 , pp. 302-312
    • Aghajanian, G.K.1    Marek, G.J.2
  • 13
    • 0035668473 scopus 로고    scopus 로고
    • The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs
    • Binder EB, Kinkead B, Owens MJ, et al. The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs. Biol Psychiatry 2001;50:856-872
    • (2001) Biol Psychiatry , vol.50 , pp. 856-872
    • Binder, E.B.1    Kinkead, B.2    Owens, M.J.3
  • 14
    • 0036174640 scopus 로고    scopus 로고
    • Glutamatergic mechanisms in schizophrenia
    • Tsai G, Coyle JT. Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 2002;42:165-179
    • (2002) Annu Rev Pharmacol Toxicol , vol.42 , pp. 165-179
    • Tsai, G.1    Coyle, J.T.2
  • 15
    • 0035028512 scopus 로고    scopus 로고
    • Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence
    • Carlsson A, Waters N, Holm-Waters S, et al. Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence. Annu Rev Pharmacol Toxicol 2001;41:237-260
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 237-260
    • Carlsson, A.1    Waters, N.2    Holm-Waters, S.3
  • 17
    • 0019519125 scopus 로고
    • Dopamine receptor supersensitivity and schizophrenia: A review
    • Langer DH, Brown GL, Docherty JP. Dopamine receptor supersensitivity and schizophrenia: A review. Schizophr Bull 1981;7:208-224
    • (1981) Schizophr Bull , vol.7 , pp. 208-224
    • Langer, D.H.1    Brown, G.L.2    Docherty, J.P.3
  • 18
    • 0035038086 scopus 로고    scopus 로고
    • Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: Implications for antipsychotic drug treatment
    • Tarazi FI, Zhang K, Baldessarini RJ. Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: Implications for antipsychotic drug treatment. J Pharmacol Exp Ther 2001;297:711-717
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 711-717
    • Tarazi, F.I.1    Zhang, K.2    Baldessarini, R.J.3
  • 19
    • 0036467316 scopus 로고    scopus 로고
    • Neurotensin: An endogenous antipsychotic?
    • Kinkead B, Nemeroff CB. Neurotensin: An endogenous antipsychotic? Curr Opin Pharmacol 2002;2:99-103
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 99-103
    • Kinkead, B.1    Nemeroff, C.B.2
  • 20
    • 0032783157 scopus 로고    scopus 로고
    • Does neurotensin mediate the effects of antipsychotic drugs?
    • Kinkead B, Binder EB, Nemeroff CB. Does neurotensin mediate the effects of antipsychotic drugs? Biol Psychiatry 1999;46:340-351
    • (1999) Biol Psychiatry , vol.46 , pp. 340-351
    • Kinkead, B.1    Binder, E.B.2    Nemeroff, C.B.3
  • 21
    • 0037093782 scopus 로고    scopus 로고
    • Neurotensin receptor binding abnormalities in the entorhinal cortex in schizophrenia and affective disorders
    • Hamid EH, Hyde TM, Egan MF, et al. Neurotensin receptor binding abnormalities in the entorhinal cortex in schizophrenia and affective disorders. Biol Psychiatry 2002;51:795-800
    • (2002) Biol Psychiatry , vol.51 , pp. 795-800
    • Hamid, E.H.1    Hyde, T.M.2    Egan, M.F.3
  • 22
    • 0019196312 scopus 로고
    • Increase of neurotensin content elicited by neuroleptics in nucleus accumbens
    • Govoni S, Hong JS, Yang HY, et al. Increase of neurotensin content elicited by neuroleptics in nucleus accumbens. J Pharmacol Exp Ther 1980;215: 413-417
    • (1980) J Pharmacol Exp Ther , vol.215 , pp. 413-417
    • Govoni, S.1    Hong, J.S.2    Yang, H.Y.3
  • 23
    • 0023877798 scopus 로고
    • Differential effects of antipsychotic drugs on the neurotensin concentration of discrete rat brain nuclei
    • Kilts CD, Anderson CM, Bissette G, et al. Differential effects of antipsychotic drugs on the neurotensin concentration of discrete rat brain nuclei. Biochem Pharmacol 1988;37:1547-1554
    • (1988) Biochem Pharmacol , vol.37 , pp. 1547-1554
    • Kilts, C.D.1    Anderson, C.M.2    Bissette, G.3
  • 24
    • 0026556812 scopus 로고
    • Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum
    • Merchant KM, Dobner PR, Dorsa DM. Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum. J Neurosci 1992;12:652-663
    • (1992) J Neurosci , vol.12 , pp. 652-663
    • Merchant, K.M.1    Dobner, P.R.2    Dorsa, D.M.3
  • 25
    • 0032530797 scopus 로고    scopus 로고
    • Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions
    • Radke JM, Owens MJ, Ritchie JC, et al. Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions. Proc Natl Acad Sci U S A 1998;95:11462-11464
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11462-11464
    • Radke, J.M.1    Owens, M.J.2    Ritchie, J.C.3
  • 26
    • 0033820521 scopus 로고    scopus 로고
    • Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain
    • Kinkead B, Shahid S, Owens MJ, et al. Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain. J Pharmacol Exp Ther 2000;295:67-73
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 67-73
    • Kinkead, B.1    Shahid, S.2    Owens, M.J.3
  • 27
    • 0024425142 scopus 로고
    • The use of c-fos as a metabolic marker in neuronal pathway tracing
    • Dragunow M, Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods 1989;29:261-265
    • (1989) J Neurosci Methods , vol.29 , pp. 261-265
    • Dragunow, M.1    Faull, R.2
  • 28
    • 0025191503 scopus 로고
    • D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons
    • Dragunow M, Robertson GS, Faull RL, et al. D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons. Neuroscience 1990;37:287-294
    • (1990) Neuroscience , vol.37 , pp. 287-294
    • Dragunow, M.1    Robertson, G.S.2    Faull, R.L.3
  • 29
    • 0028135046 scopus 로고
    • Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity
    • Robertson GS, Matsumura H, Fibiger HC. Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity. J Pharmacol Exp Ther 1994;271:1058-1066
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1058-1066
    • Robertson, G.S.1    Matsumura, H.2    Fibiger, H.C.3
  • 30
    • 0034843738 scopus 로고    scopus 로고
    • The emerging role of glutamate in the pathophysiology and treatment of schizophrenia
    • Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry 2001;158:1367-1377
    • (2001) Am J Psychiatry , vol.158 , pp. 1367-1377
    • Goff, D.C.1    Coyle, J.T.2
  • 32
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 1995;52:998-1007
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 33
    • 0033051436 scopus 로고    scopus 로고
    • Regulation of ionotropic glutamate receptors in the rat brain in response to the atypical antipsychotic Seroquel (quetiapine fumarate)
    • Tascedda F, Lovati E, Blom JM, et al. Regulation of ionotropic glutamate receptors in the rat brain in response to the atypical antipsychotic Seroquel (quetiapine fumarate). Neuropsychopharmacology 1999;21:211-217
    • (1999) Neuropsychopharmacology , vol.21 , pp. 211-217
    • Tascedda, F.1    Lovati, E.2    Blom, J.M.3
  • 34
    • 0000754856 scopus 로고    scopus 로고
    • Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients
    • Takahashi M, Shirakawa O, Toyooka K, et al. Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients. Mol Psychiatry 2000;5:293-300
    • (2000) Mol Psychiatry , vol.5 , pp. 293-300
    • Takahashi, M.1    Shirakawa, O.2    Toyooka, K.3
  • 35
    • 0033079596 scopus 로고    scopus 로고
    • Neurotrophins and depression
    • Altar CA. Neurotrophins and depression. Trends Pharmacol Sci 1999;20: 59-61
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 59-61
    • Altar, C.A.1
  • 36
    • 0024990331 scopus 로고
    • Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons
    • Phillips HS, Hains JM, Laramee GR, et al. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science 1990;250:290-294
    • (1990) Science , vol.250 , pp. 290-294
    • Phillips, H.S.1    Hains, J.M.2    Laramee, G.R.3
  • 37
    • 0032924127 scopus 로고    scopus 로고
    • The neuropathology of schizophrenia: A critical review of the data and their interpretation
    • Harrison PJ. The neuropathology of schizophrenia: A critical review of the data and their interpretation. Brain 1999;122:593-624
    • (1999) Brain , vol.122 , pp. 593-624
    • Harrison, P.J.1
  • 38
    • 0035179309 scopus 로고    scopus 로고
    • At issue: Stress, hippocampal neuronal turnover, and neuropsychiatric disorders
    • Arango C, Kirkpatrick B, Koenig J. At issue: Stress, hippocampal neuronal turnover, and neuropsychiatric disorders. Schizophr Bull 2001;27:477-480
    • (2001) Schizophr Bull , vol.27 , pp. 477-480
    • Arango, C.1    Kirkpatrick, B.2    Koenig, J.3
  • 39
    • 0034730571 scopus 로고    scopus 로고
    • Stress in schizophrenia: An integrative view
    • Gispen-de Wied CC. Stress in schizophrenia: An integrative view. Eur J Pharmacol 2000;405:375-384
    • (2000) Eur J Pharmacol , vol.405 , pp. 375-384
    • Gispen-de Wied, C.C.1
  • 40
    • 0037087022 scopus 로고    scopus 로고
    • Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus
    • Xu H, Qing H, Lu W, et al. Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci Lett 2002;321:65-68
    • (2002) Neurosci Lett , vol.321 , pp. 65-68
    • Xu, H.1    Qing, H.2    Lu, W.3
  • 41
    • 17844379465 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of quetiapine: An atypical antipsychotic
    • DeVane CL, Nemeroff CB. Clinical pharmacokinetics of quetiapine: An atypical antipsychotic. Clin Pharmacokinet 2001;40:509-522
    • (2001) Clin Pharmacokinet , vol.40 , pp. 509-522
    • DeVane, C.L.1    Nemeroff, C.B.2
  • 42
    • 0034071578 scopus 로고    scopus 로고
    • Pharmacokinetics, tolerability, and clinical effectiveness of quetiapine fumarate: An open-label trial in adolescents with psychotic disorders
    • McConville BJ, Arvanitis LA, Thyrum PT, et al. Pharmacokinetics, tolerability, and clinical effectiveness of quetiapine fumarate: An open-label trial in adolescents with psychotic disorders. J Clin Psychiatry 2000;61:252-260
    • (2000) J Clin Psychiatry , vol.61 , pp. 252-260
    • McConville, B.J.1    Arvanitis, L.A.2    Thyrum, P.T.3
  • 43
    • 0034190597 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of quetiapine in subjects with renal or hepatic impairment
    • Thyrum PT, Wong YW, Yeh C. Single-dose pharmacokinetics of quetiapine in subjects with renal or hepatic impairment. Prog Neuropsychopharmacol Biol Psychiatry 2000;24:521-533
    • (2000) Prog Neuropsychopharmacol Biol Psychiatry , vol.24 , pp. 521-533
    • Thyrum, P.T.1    Wong, Y.W.2    Yeh, C.3
  • 44
    • 0036219957 scopus 로고    scopus 로고
    • The safety and pharmacokinetics of quetiapine when coadministered with haloperidol, risperidone, or thioridazine
    • Potkin SG, Thyrum PT, Alva G, et al. The safety and pharmacokinetics of quetiapine when coadministered with haloperidol, risperidone, or thioridazine. J Clin Psychopharmacol 2002;22:121-130
    • (2002) J Clin Psychopharmacol , vol.22 , pp. 121-130
    • Potkin, S.G.1    Thyrum, P.T.2    Alva, G.3
  • 45
    • 0036215039 scopus 로고    scopus 로고
    • Effect of fluoxetine and imipramine on the pharmacokinetics and tolerability of the antipsychotic quetiapine
    • Potkin SG, Thyrum PT, Alva G, et al. Effect of fluoxetine and imipramine on the pharmacokinetics and tolerability of the antipsychotic quetiapine. J Clin Psychopharmacol 2002;22:174-182
    • (2002) J Clin Psychopharmacol , vol.22 , pp. 174-182
    • Potkin, S.G.1    Thyrum, P.T.2    Alva, G.3
  • 46
    • 0001205271 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of lithium coadministered with Seroquel (quetiapine)
    • Potkin S, Thyrum P, Bera R, et al. Pharmacokinetics and safety of lithium coadministered with Seroquel (quetiapine) [abstract]. Schizophr Res 1997; 24:199
    • (1997) Schizophr Res , vol.24 , pp. 199
    • Potkin, S.1    Thyrum, P.2    Bera, R.3
  • 47
    • 0036217258 scopus 로고    scopus 로고
    • The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders
    • Strakowski SM, Keck PE Jr, Wong YW, et al. The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders. J Clin Psychopharmacol 2002;22: 201-205
    • (2002) J Clin Psychopharmacol , vol.22 , pp. 201-205
    • Strakowski, S.M.1    Keck P.E., Jr.2    Wong, Y.W.3
  • 48
    • 0035142323 scopus 로고    scopus 로고
    • The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine
    • Wong YW, Yeh C, Thyrum PT. The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine. J Clin Psychopharmacol 2001;21:89-93
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 89-93
    • Wong, Y.W.1    Yeh, C.2    Thyrum, P.T.3
  • 49
    • 0036190196 scopus 로고    scopus 로고
    • Dosing and switching strategies for quetiapine fumarate
    • Cutler AJ, Goldstein JM, Tumas JA. Dosing and switching strategies for quetiapine fumarate. Clin Ther 2002;24:209-222
    • (2002) Clin Ther , vol.24 , pp. 209-222
    • Cutler, A.J.1    Goldstein, J.M.2    Tumas, J.A.3
  • 50
    • 0031963279 scopus 로고    scopus 로고
    • Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia
    • Gefvert O, Bergstrom M, Langstrom B, et al. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology (Berl) 1998;135:119-126
    • (1998) Psychopharmacology (Berl) , vol.135 , pp. 119-126
    • Gefvert, O.1    Bergstrom, M.2    Langstrom, B.3
  • 51
    • 0012189924 scopus 로고    scopus 로고
    • A random-assignment, double-blind, clinical trial of once- versus twice-daily administration of quetiapine fumarate in patients with schizophrenia or schizoaffective disorder
    • Dec 9-13; Waikoloa, Hawaii
    • Goldstein J, Chengappa KR, Parepally H, et al. A random-assignment, double-blind, clinical trial of once- versus twice-daily administration of quetiapine fumarate in patients with schizophrenia or schizoaffective disorder. Presented at the 40th Annual Meeting of the American College of Neuropsychopharmacology; Dec 9-13, 2001; Waikoloa, Hawaii
    • (2001) 40th Annual Meeting of the American College of Neuropsychopharmacology
    • Goldstein, J.1    Chengappa, K.R.2    Parepally, H.3
  • 52
    • 0003280925 scopus 로고    scopus 로고
    • Safety and tolerability of switching from conventional antipsychotic therapy to Seroquel (quetiapine fumarate) followed by withdrawal from Seroquel
    • Dec 8-12; Waikoloa, Hawaii
    • Thyrum PR, Yeh C, Potkin SG, et al. Safety and tolerability of switching from conventional antipsychotic therapy to Seroquel (quetiapine fumarate) followed by withdrawal from Seroquel. Presented at the 36th Annual Meeting of the American College of Neuropsychopharmacology; Dec 8-12, 1997; Waikoloa, Hawaii
    • (1997) 36th Annual Meeting of the American College of Neuropsychopharmacology
    • Thyrum, P.R.1    Yeh, C.2    Potkin, S.G.3
  • 53
    • 0034025771 scopus 로고    scopus 로고
    • Relationship between dopamine D(2) occupancy, clinical response, and side effects: A double-blind PET study of first-episode schizophrenia
    • Kapur S, Zipursky R, Jones C, et al. Relationship between dopamine D(2) occupancy, clinical response, and side effects: A double-blind PET study of first-episode schizophrenia. Am J Psychiatry 2000;157:514-520
    • (2000) Am J Psychiatry , vol.157 , pp. 514-520
    • Kapur, S.1    Zipursky, R.2    Jones, C.3
  • 54
    • 0035055247 scopus 로고    scopus 로고
    • D(2) and 5HT(2A) receptor occupancy of different doses of quetiapine in schizophrenia: A PET study
    • Gefvert O, Lundberg T, Wieselgren IM, et al. D(2) and 5HT(2A) receptor occupancy of different doses of quetiapine in schizophrenia: A PET study. Eur Neuropsychopharmacol 2001;11:105-110
    • (2001) Eur Neuropsychopharmacol , vol.11 , pp. 105-110
    • Gefvert, O.1    Lundberg, T.2    Wieselgren, I.M.3
  • 55
    • 0030781165 scopus 로고    scopus 로고
    • IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol
    • Kufferle B, Tauscher J, Asenbaum S, et al. IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol. Psychopharmacology (Berl) 1997;133:323-328
    • (1997) Psychopharmacology (Berl) , vol.133 , pp. 323-328
    • Kufferle, B.1    Tauscher, J.2    Asenbaum, S.3
  • 56
    • 0034091239 scopus 로고    scopus 로고
    • A positron emission tomography study of quetiapine in schizophrenia: A preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy
    • Kapur S, Zipursky R, Jones C, et al. A positron emission tomography study of quetiapine in schizophrenia: A preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy. Arch Gen Psychiatry 2000;57:553-559
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 553-559
    • Kapur, S.1    Zipursky, R.2    Jones, C.3
  • 57
    • 0031953450 scopus 로고    scopus 로고
    • Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors
    • Seeman P, Tallerico T. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol Psychiatry 1998;3:123-134
    • (1998) Mol Psychiatry , vol.3 , pp. 123-134
    • Seeman, P.1    Tallerico, T.2
  • 58
    • 0033768430 scopus 로고    scopus 로고
    • Striatal and extrastriatal D(2)/D(3) dopamine receptor occupancy by quetiapine in vivo: [(123)I]-epidepride single photon emission tomography (SPET) study
    • Stephenson CM, Bigliani V, Jones HM, et al. Striatal and extrastriatal D(2)/D(3) dopamine receptor occupancy by quetiapine in vivo: [(123)I]-epidepride single photon emission tomography (SPET) study. Br J Psychiatry 2000;177:408-415
    • (2000) Br J Psychiatry , vol.177 , pp. 408-415
    • Stephenson, C.M.1    Bigliani, V.2    Jones, H.M.3
  • 59
    • 0034742035 scopus 로고    scopus 로고
    • In vivo 5-HT2A receptor blockade by quetiapine: An R91150 single photon emission tomography study
    • Jones HM, Travis MJ, Mulligan R, et al. In vivo 5-HT2A receptor blockade by quetiapine: An R91150 single photon emission tomography study. Psychopharmacology (Berl) 2001;157:60-66
    • (2001) Psychopharmacology (Berl) , vol.157 , pp. 60-66
    • Jones, H.M.1    Travis, M.J.2    Mulligan, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.