Activin a induction of cell-cycle arrest involves modulation of cyclin D2 and(CIP1/WAF1) in plasmacytic cells

Molecular Endocrinology

Volumn 11, Issue 8, 1997, Pages 1044-1052

  Yamato, Kenji ^a,b   Koseki, Takeyoshi ^a   Ohguchi, Masahiro ^a   Kizaki, Masahiro ^c   Ikeda, Yasuo ^c   Nishihara, Tatsuji ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; CYCLINE; PROTEIN P21;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL GROWTH; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; GROWTH REGULATION; HORMONAL REGULATION; HORMONE ACTION; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION;

EID: 0030996527     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.8.9953     Document Type: Article

References (49)

1. Vale W, Rivier J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J 1986 Purification and characterization of an FSH releasing protein from ovarian follicular fluid. Nature 321:732-734
2. Ling N, Ying SY, Ueno N, Shimasami S, Esch F, Hota M, Guillemin R 1986 Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Nature 321:779-782
3. Massagué J 1987 The TGF-β family of growth and differentiation factors. Cell 49:437-438
4. Høtten G, Neidhardt H, Schneider C, Pohl J 1995 Cloning of a new member of the TGF-beta family: a putative new activin beta C chain. Biochem Biophys Res Commun 206:608-613
5. Oda S, Nishimura S, Murakami K, Ueno N 1995 Molecular cloning and functional analysis of a new activin beta subunit: dorsal mesoderm-inducing activity in Xenopus. Biochem Biophys Res Commun 206:581-588
6. Eto Y, Tsuji T, Takezawa M, Takano Y, Yokogawa Y, Shibai H 1987 Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1. Biochem Biophys Res Commun 142:1095-1103
7. Green JB, Smith JC 1990 Graded changes in dose of a Xenopus activin A-homologue elicit stepwise transitions in embryonic cell fate. Nature 347:391-394
8. Smith JC, Price BMJ, Van Nimmen K, Huylebroeck D 1990 Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin-A. Nature 345:729-731
9. Sokol S, Melton DA 1991 Pre-existent pattern in Xenopus pole cells revealed by induction with activin. Nature 351:409-411
10. Smith JC 1993 Mesoderm-inducing factors in early vertebrate development. EMBO J 12:4463-4470
11. Gonzalez-Manchon C, Vale W 1989 Activin A, inhibin and TGF-β modulate growth of two gonadal cell lines. Endocrinology 125:1666-1672
12. Kojima I, Ogata E 1989 Dual effect of activin on cell growth in Balb/c 3T3 cells. Biochem Biophys Res Commun 159:1107-1113
13. Spencer SJ, Rabinovici J, Jaffe RB 1990 Human recombinant activin-A inhibits proliferation of human fetal adrenal cells in vitro. J Clin Endocrinol Metab 71:1678-1680
14. McCarthy S, Bicknell R 1993 Inhibition of vascular endothelial cell growth. J Biol Chem 268:23066-23071
15. Nishihara T, Okahashi N, Ueda N 1993 Activin A induces apoptotic cell death. Biochem Biophys Res Commun 197:985-991
16. Nishihara T, Ohsaki Y, Ueda N, Koseki T, Eto Y 1995 Induction of apoptosis in B lineage cells by activin A derived from macrophages. J Interferon Cytokine Res 15:509-516
17. Brosh N, Sternberg D, Honigwachs-Sha'anani J, Lee B-C, Shav-Tal Y, Tzehoval E, Shulman LM, Tolendo J, Hacham Y, Carmi P, Jiang W, Horn F, Burstein Y, Zipori D 1995 The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11. J Biol Chem 270:29594-29600
18. Koseki T, Yamato K, Krajewski S, Reed JC, Tsujimoto Y, Nishihara T 1995 Activin A-induced apoptosis is suppressed by overexpression of Bcl-2. FEBS Lett 376:247-250
19. Weinberg RA 1995 The retinoblastoma protein and cell cycle control. Cell 81:323-330
20. Nevins JR 1992 E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429
21. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ 1991 Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65:701-713
22. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM 1993 Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487-497
23. PSK-3/cdk4) for mammalian D type G1 cyclins. Cell 71:323-334
24. Sherr CJ, Roberts JM 1995 Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9:1149-1163
25. El-Deiry WS, Tokino T, Velculescu VE, Levy R, Parsons R, Trent JM, Lin D, Mercer E, Kinzler KW, Vogelstein B 1993 WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825
26. Gu Y, Turek CW, Morgan DO 1993 Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366:707-710
27. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ 1993 The p21 cdk-interacting protein Cip 1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816
28. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D 1993 p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704
29. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR 1994 Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98
30. kip1, a cyclin-cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev 8:9-22
31. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular mitogenic signals. Cell 78:59-66
32. Toyoshima H, Hunter T 1994 p27, a novel inhibitor of G1 cyclin/cdk protein kinase activity, is related to p21. Cell 78:67-74
33. Chen J, Jackson PK, Kirschner MW, Dutta A 1995 Separate domains of p21 involved in the cdk kinase and PCNA. Nature 374:386-388
34. CIP1. Nature 375:159-161
35. sdi1/CIP1/WAF1. EMBO J 14:555-563
36. Elendary A, Berchuck A, Davis P, Havrilesky L, Bast JRC, Iglehart JD, Marks JR 1994 Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ 5:1301-1307
37. Reynisdóttir I, Polyak K, Massagué J 1995 Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev 9:1831-1845
38. Serrano M, Hannon GJ, Beach D 1993 A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/cdk4. Nature 366:704-707
39. INK4b is a potential effector of TGF-β-induced cell cycle arrest. Nature 371:257-261
40. Peters G 1994 Stifled by inhibitions. Nature 371:204-205
41. Gu Y, Rosenblatt J, Morgan DO 1992 Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J 11:3995-4005
42. Laiho M, CeCaprio JA, Ludlow JW, Livingston DM, Massagué J 1990 Growth inhibition by TGFβ linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175-185
43. Mosmann T 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
44. A chain. Proc Natl Acad Sci USA 85:2434-2338
45. DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR 1995 E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev 9:2873-2887
46. Kitagawa M, Higashi H, Jung H-K, Suzuki-Takahashi I, Ikeda M, Tamai K, Kato J, Segawa K, Yoshida E, Nishimura S, Taya Y 1996 The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 15:7060-7069
47. Tokunaga K, Nakamura Y, Sakata K, Fujimori K, Ohkubo M, Sawada K, Sakiyama S 1987 Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res 47:5616-5619
48. Sugito S, Yamato K, Sameshima Y, Yokota J, Yano S, Miyoshi I 1991 Adult T-cell leukemia: structures and expression of the p53 gene, Int J Cancer 49:880-885
49. INK4b genes. Oncogene 11:635-645