Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (γ-glutamate) metabolites

Biochemical Pharmacology

Volumn 52, Issue 8, 1996, Pages 1295-1303

  McGuire, John J ^a   Hart, Barry P ^b   Haile, William H ^a   Magee, Kathryn J ^a   Rhee, Myung ^c   Bolanowska, Wanda E ^a   Russell, Cynthia ^a   Galivan, John ^c   Paul, Brajeswar ^a   Coward, James K ^b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c WADSWORTH CENTER   (United States)

Author keywords

3,3 difluoroglutamate; 4 fluoroglutamate; folic acid; folylpolyglutamate synthetase; leucovorin; methotrexate; polyglutamate

Indexed keywords

FLOXURIDINE; FOLIC ACID; FOLIC ACID DERIVATIVE; FOLINIC ACID; GAMMA FLUOROFOLIC ACID; GAMMA FLUOROFOLINIC ACID; GAMMA FLUOROMETHOTREXATE; GAMMA,GAMMA DIFLUOROFOLIC ACID; METHOTREXATE; METHOTREXATE DERIVATIVE; POLYGLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPLETION; DRUG METABOLISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; HEPATOMA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY;

EID: 0030601896     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00485-6     Document Type: Article

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