Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model

Cancer Chemotherapy and Pharmacology

Volumn 50, Issue 5, 2002, Pages 392-396

  Guarnieri, Michael ^a   Biser Rohrbaugh, Ann ^a   Tyler, Betty M ^a   Gabikian, Patrik ^a   Bunton, Tracie E ^a   Ze Wu, Qing ^a   Weingart, Jon ^a   Carson Sr , Benjamin S ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Bis chloroethyl nitrosourea (BCNU); O6 alkylguanine DNA alkyl transferase (AGAT, MGMT); O6 benzyl guanine (O6BG)

Indexed keywords

6 O BENZYLGUANINE; CARMUSTINE; POLYMER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; BLOOD CELL COUNT; BONE MARROW; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFECT; DRUG INHIBITION; DRUG RESPONSE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; SURVIVAL; TOXICITY;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW DISEASES; CARMUSTINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG IMPLANTS; DRUG SYNERGISM; GUANINE; INFLAMMATION; INFUSION PUMPS, IMPLANTABLE; INFUSIONS, PARENTERAL; MICE; MICE, INBRED BALB C; NECROSIS; PARIETAL LOBE; PERITONEAL CAVITY;

EID: 0036450553     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-002-0510-y     Document Type: Article

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