Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea

Cancer Chemotherapy and Pharmacology

Volumn 39, Issue 4, 1997, Pages 307-316

  Kurpad, Shekar N ^a   Dolan, M Eileen ^b   McLendon, Roger E ^c   Archer, Gerald E ^c   Moschel, Robert C ^d   Pegg, Anthony E ^e   Bigner, Darell D ^c   Friedman, Henry S ^c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

BCNU; Chemotherapy; Drug resistance; Gliomas; O6 benzylguanine

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; CARMUSTINE; ALKYLATING AGENT; DNA ALKYLTRANSFERASE; DRUG DERIVATIVE; GUANINE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE; TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TOXICITY; CANCER GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SENSITIVITY; ENZYME ACTIVITY; GLIOMA; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR XENOGRAFT; ANIMAL; BRAIN TUMOR; DNA REPAIR; DRUG ANTAGONISM; DRUG RESISTANCE; GLIOBLASTOMA; METABOLISM; NUDE RAT; XENOGRAFT;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; CARMUSTINE; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; GLIOBLASTOMA; GUANINE; HUMANS; INJECTIONS, INTRA-ARTERIAL; RATS; RATS, NUDE; TRANSFERASES; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030614374     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050577     Document Type: Article

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