Destruction of neurokinin-l receptor expressing cells in vitro and in vivo using substance P-saporin in rats

Neuroscience Letters

Volumn 230, Issue 2, 1997, Pages 97-100

  Wiley, R G ^a   Lappi, D A ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Advanced Targeting Systems   (United States)

Author keywords

Neurokinin 1 receptor; Rat; Saporin; Striatum; Substance P

Indexed keywords

NEUROKININ 1 RECEPTOR; SAPORIN; ANTISERUM; BIOLOGICAL MARKER; CHOLINE ACETYLTRANSFERASE; GLYCOSIDASE; IMMUNOTOXIN; PARVALBUMIN; RECOMBINANT PROTEIN; RIP PROTEIN, SAPONARIA OFFICINALIS; SUBSTANCE P; VEGETABLE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTERNEURON; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL SURVIVAL; DRUG EFFECT; GENETIC TRANSFECTION; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BIOLOGICAL MARKERS; CELL LINE; CELL SURVIVAL; CHOLINE O-ACETYLTRANSFERASE; CORPUS STRIATUM; IMMUNE SERA; IMMUNOHISTOCHEMISTRY; IMMUNOTOXINS; INTERNEURONS; N-GLYCOSYL HYDROLASES; PARVALBUMINS; PLANT PROTEINS; RATS; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS; SUBSTANCE P; TRANSFECTION;

EID: 0030611241     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00490-4     Document Type: Article

References (16)

1. Anton, P.A., Reeve, J. Jr., Vidrich, A., Mayer, E. and Shanahan, S., Development of a biotinylated analog of substance P for use as a receptor probe, Lab. Invest., 64 (1991) 703-708.
2. Fisher, C.E., Sutherland, J.A., Krause, J.E., Murphy, J.R., Leeman, S.E. and vanderSpek, J.C., Genetic construction and properties of a diphtheria toxin-related substance P fusion protein: in vitro destruction of cells bearing substance preceptors, Proc. Natl. Acad. Sci. USA, 93 (1996) 7341-7345.
3. Grady, E.F., Garland, A.M., Gamp, P.D., Lovett, M., Payan, D.G. and Bunnett, N.W., Delineation of the endocytotic pathway of substance P and its seven-transmembrane domain NK1 receptor, Mol. Biol. Cell, 6 (1995) 509-524.
4. Kaneko, T., Shigemoto, R., Nakanishi, S. and Mizuno, N., Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons, Brain Res., 631 (1993) 297-303.
5. Kawaguchi, Y., Wilson, C.J., Augood, S.J. and Emson, P.C., Striatal interneurones: chemical, physiological and morphological characterization, Trends Neurosci., 18 (1995) 527-535.
6. Khawaja, A.M. and Rogers, D.F., Tachykinins: receptor to effector, Int. J. Biochem. Cell Biol., 28 (1996) 721-738.
7. Lappi, D.A., Martineau, D., Sarmientos, P., Garofano, L., Aranda, A.P., Miyajima, A., Kitamura, T. and Baird, A., Characterization of a saporin mitotoxin specifically cytotoxic to cells bearing the granulocyte-macrophage colony-stimulating factor receptor, Growth Factors, 9 (1993) 31-39.
8. Mantyh, P.W., Allen, C.J., Ghilardi, J.R., Rogers, S.D., Mantyh, C.R., Liu, H., Basbaum, A.I., Vigna, S.R. and Maggio, J.E., Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo, Proc. Natl. Acad. Sci USA, 92 (1995) 2622-2626.
9. Mantyh, P.W., DeMaster, E., Malhotra, A., Ghilardi, J.R., Rogers, S.D., Manth, C.R., Liu, H., Basbaum, A.I., Vigna, S.R., Maggio, J.E. and Simone, D.A., Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation, Science, 268 (1995) 1629-1632.
10. Taoka, M., Song, S.Y., Kubota, M., Minegishi, A., Yamakuni, T. and Konishi, S., Increased level of neurokinin-1 tachykinin receptor gene expression during early postnatal development of rat brain, Neuroscience, 74 (1996) 845-853.
11. Vigna, S.R., Bowden, J.J., McDonald, D.M., Fisher, J., Okamoto, A., McVey, D.C., Payan, D.G. and Bunnett, N.W., Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells, J. Neurosci., 14 (1994) 834-845.
12. Wiley, R.G., Berbos, T.G., Deckwerth, T.L., Johnson, E.M. Jr. and Lappi, D.A., Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: modeling the cholinergic degeneration of Alzheimer's disease, J. Neurol. Sci., 128 (1995) 157-166.
13. Wiley, R.G. and Lappi, D.A., Suicide transport and immunolesioning, R.G. Landes Medical Publishers, Austin, TX, 1994, pp. 77-83.
14. Wiley, R.G., Oeltmann, T.N. and Lappi, D.A., Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor, Brain Res., 562 (1991) 149-153.
15. Wiley, R.G. and Stirpe, E., Modeccin and volkensin but not abrin are effective suicide transport agents in rat CNS, Brain Res., 438 (1987) 145-154.
16. Wrenn, C.C., Picklo, M.J., Lappi, D.A., Robertson, D. and Wiley, R.G., Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings, Brain Res., 740 (1996) 175-184.