Role of central 5-HT2 receptors in fluoxetine-induced decreases in T lymphocyte activity

Brain, Behavior, and Immunity

Volumn 16, Issue 2, 2002, Pages 87-103

  Pellegrino, Trisha C ^a   Bayer, Barbara M ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5 HT2 receptor; 8 OH DPAT; Central; Concanavalin A; DOI; Fluoxetine; Immunity; Ketanserin; Lymphocyte proliferation; Ritanserin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; FLUOXETINE; KETANSERIN; MITOGENIC AGENT; RITANSERIN; SEROTONIN 1A AGONIST; SEROTONIN 2 ANTAGONIST; SEROTONIN 2 RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG ANTAGONISM; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

EID: 0036444334     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1006/brbi.2001.0625     Document Type: Article

References (82)

1. Ader, R., Felten, D. L., & Cohen, N. (1990). Interactions between the brain and the immune system. Annu. Rev. Pharmacol. Toxicol. 30, 561-602.
2. Afzelius, P., Nielsen, S. D., Hofmann, B., & Nielsen, J. O. (1997). The serotonin analogue buspirone increases the function of PBMC from HIV-infected individuals in vitro. Scand. J. Infect. Dis. 29, 117-120.
3. 2C receptors. Biol. Psychiat. 39, 1000-1008.
4. Ameisen, J.-C., Meade, R., & Askenase, P. W. (1989). A new interpretation of the involvement of serotonin in delayed-type hypersensitivity: Serotonin-2 receptor antagonists inhibit contact sensitivity by an effect on T cells. J. Immunol. 142, 3171-3179.
5. Apfelbaum, M. E. (1998). Role of vasoactive intestinal peptide and 5-HT2 receptor subtype in serotonin stimulation of basal and thyrotropin-releasing-hormone-induced prolactin release in vitro from rat pituitary cells. Neuroendocrinology 67, 45-50.
6. Arzi, E., Costas, M., Finkielman, S., & Nahmod, V. E. (1991). Serotonin inhibition of tumor necrosis factor-α synthesis by human monocytes. Life Sci. 48, 2557-2562.
7. Aune, T. M., McGrath, K. M., Sarr, T., Bombara, M. P., & Kelley, K. A. (1993). Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. J. Immunol. 151, 1175-1183.
8. Aune, T. M., Golden, H. W., & McGrath, K. M. (1994). Inhibitors of serotonin synthesis and antagonists and serotonin 1A receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo. J. Immunol. 153, 489-498.
9. Bagdy, G., Sved, A. F., Murphy, D. L., & Szemeredi, K. (1992). Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur. J. Pharmacol. 210, 285-289.
10. Berkeley, M. B., Daussin, S., Hernandez, M. C., & Bayer, B. M. (1994). In vitro effects of cocaine, lidocaine, and monoamine uptake inhibitors on lymphocyte proliferative responses. Immunopharmacol. Immunotoxicol. 16, 165-178.
11. Bianchi, M., Rossoni, G., Sacerdote, P., Panerai, A. E., & Berti, F. (1995). Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat. Inflamm. Res. 44, 466-469.
12. Bianchi, M., Sacerdote, P., & Panerai, A. E. (1994). Fluoxetine reduces inflammatory edema in the rat: Involvement of the pituitary-adrenal axis. Eur. J. Pharmacol. 263, 81-84.
13. Bliznakov, E. G. (1980). Serotonin and its precursors as modulators of the immunological responsiveness in mice. J. Med. 11, 81-105.
14. Bonnet, M., Lespinats, G., & Burtin, C. (1984). Histamine and serotonin suppression of lymphocyte response to phytohemagglutin and allogeneic cells. Cell. Immunol. 83, 280-291.
15. Brandes, L. J., Arron, R. J., Bogdanovic, R. P., Tong, J., Zaborniak, C. L. F., Hogg, G. R., Warrington, R. C., Fang, W., & LaBella, F. S. (1992). Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses. Cancer Res. 52, 3796-3800.
16. Caccia, S., Cappi, M., Fracasso, C., & Garattini, S. (1990). Influence of dose and route of administration of the kinetics of fluoxetine and its metabolite norfluoxetine in the rat. Psychopharmacology 100, 509-514.
17. Cervo, L., Grignaschi, G., & Samanin, R. (1988). 8-Hydroxy-2-(di-n-propylamino)tetralin, a selective serotonin1A receptor agonist, reduces the immobility of rats in the forced swimming test by acting on the nucleus raphe dorsalis. Eur. J. Pharmacol. 158, 53-59.
18. Choquet, D., & Korn, H. (1988). Dual effect of serotonin on a voltage-gated conductance in lymphocytes. Proc. Natl. Acad. Sci., 85, 4557-4561.
19. Connor, T. J., Kelly, J. P., & Leonard, B. E. (2000). An assessment of the acute effects of serotonin releasers methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on immunity in rats. Immunopharmacology 46, 223-235.
20. Crowson, A. N., & Magro, C. M. (1995). Antidepressant therapy: A possible cause of atypical cutaneous lymphoid hyperplasia. Arch. Dermatol. 131, 925-929.
21. Dedeoglu, A., & Fisher, L. A. (1991). Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. J. Pharmacol. Exp. Ther. 259, 1027-1034.
22. Devoino, L., Eliseeva, L., Eremina, O., Idova, G., & Cheido, M. (1976). 5-Hydroxytryptophan effect on the development of the immune response: IgM and IgG antibodies and rosette formation in primary and secondary responses. Eur. J. Immunol. 5, 394-399.
23. Devoino, L., Morozova, N., & Cheido, M. (1988). Participation of serotonergic system in neuroimmunomodulation: Intraimmune mechanisms and the pathways providing an inhibitory effect. Int. J. Neurosci. 40, 111-128.
24. Devoino, L. V., & Ilyutchenok, R. Y. (1968). Influence of some drugs on the immune response. II. Effects of serotonin, 5-hydroxytryptophan, reserpine and iproniazid on delayed hypersensitivity. Eur. J. Pharmacol. 4, 449-456.
25. Eugen-Olsen, J., Afzelius, P., Andresen, L., Iversen, J., Kronborg, G., Aabech, P., Nielsen, J. O., & Hofmann, B. (1997). Serotonin modulates immune function in T cells from HIV-seropositive subjects. Clin. Immunol. Immunopathol. 84, 115-121.
26. Felten, D. L., Felten, S. Y., Bellinger, D. L., Carlson, S. L., Kurt, D. A., Madden, K. S., Olschowki, J. A., & Livnat, S. (1987). Noradrenergic sympathetic neural interactions with the immune system: Structure and function. Immunol. Rev. 100, 225-260.
27. Freedman, B., Price, M. A., & Deutsch, C. J. (1992). Evidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes. J. Immunol. 149, 3784-3794.
28. Frenken, M., & Kaumann, A. J. (1987). Allosteric properties of 5-HT2 receptor system of the rat tail artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 359-366.
29. Garsaddi, S. I., Mandi, Y., Regely, K., Tarodi, B., & Beladi, I. (1993). The inhibitory effect of interferon-alpha on the serotonin-induced impairment of human NK cell activity in whole blood. Brain Behav. Immun. 7, 164-175.
30. Glennon, R. A. (1987). Central serotonin receptors as targets for drug research. J. Med. Chem. 30, 1-12.
31. Graeff, F. G., Guimaraes, F. S., De Andrade, T. G. C. S., & Deakin, J. F. W. (1996). Role of 5-HT in stress, anxiety, and depression. Pharmacol. Biochem. Behav., 54, 129-141.
32. 1-adrenoceptors. J. Cardiovasc. Pharmacol. 27, 854-860.
33. Gripenberg, J. (1976). Inhibition of reserpine, guanethidine and imipramine of the uptake of 5-hydroxytryptamine by rat peritoneal mast cells in vitro. Acta Physiol. Scand. 96, 407-416.
34. Haleem, D. J. (1999). Attenuation of 8-OH-DPAT-induced decreases in 5-Ht synthesis in brain regions of rats adapted to a repeated stress schedule. Stress 3, 123-129.
35. Hellstrand, K., & Hermodsson, S. (1987). Role of serotonin in the regulation of human natural killer cell cytotoxicity. J. Immunol. 139, 869-875.
36. Hellstrand, K., & Hermodsson, S. (1993). Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes. Scand. J. Immun. 37, 7-18.
37. Hennig, J., Becker, H., & Netter, P. (1996). 5-HT agonist-induced changes in peripheral immune cells in healthy volunteers: The impact of personality. Behav. Brain Res. 73, 359-363.
38. Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994). International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46, 157-203.
39. 1A receptors. Cell. Immunol. 163, 1-9.
40. Jackson, J. C., Cross, R. J., Walker, R. F., Markesbery, W. R., & Brooks, W. H. (1985). Influence of serotonin on the immune response. Immunology 54, 505-512.
41. Jackson, J. C., Walker, R. F., Brooks, W. H., & Roszman, T. L. (1988). Specific uptake of serotonin by murine macrophages. Life Sci. 42, 1641-1650.
42. Khan, I. A., Bhardwaj, G., Malla, N., Wattal, C., & Agarwal, S. C. (1986). Effect of serotonin on T lymphocyte proliferation in vitro in healthy individuals. Int. Arch. Allergy Appl. Immunol. 81, 378-380.
43. Koenig, J. I., Gudelsky, G. A., & Meltzer, H. Y. (1987). Stimulation of corticosterone and B-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur. J. Pharm. 137, 1-8.
44. Kut, J. L., Crayton, J., Wright, M., & Young, M. (1992). Regulation of murine T-lymphocyte function by spleen cell-derived and exogenous serotonin. Immunopharmacol. Immunotoxicol. 14, 783-796.
45. Leonhardt, S., Gorospe, E., Hoffman, B. J., & Teitler, M. (1992). Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Mol. Pharmacol. 42, 328-335.
46. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., & Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531.
47. 2 receptor agonist DOI. Eur. J. Pharmacol. 221, 121-127.
48. 1A) receptor mRNA within binding of [3H]-8-OH-DPAT in peripheral blood mononuclear cells. Life Sci. 57, 2197-2203.
49. McCall, R. B., & Clement, M. E. (1994). Role of serotonin1A and serotonin2 receptors in the central regulation of the cardiovascular system. Pharmacol. Rev. 46, 231-243.
50. Nannmark, U., Sennerby, L., Bjursten, L.-M., Skolnik, G., & Bagge, U. (1992). Inhibition of leukocyte phagocytosis by sertonin and its possible role in tumor cell destruction. Cancer Lett. 62, 83-86.
51. 2A/2C agonist. J. Med. Chem. 37, 4346-4351.
52. Nordlind, K., & Sundstrom, E. (1988). Different modulating effects of the monoamines adrenaline, noradrenaline, and serotonin on the DNA synthesis response of human peripheral blood T lymphocytes activated by mercuric chloride and nickel sulfate. Int. Arch. Allergy Appl. Immunol. 87, 317-320.
53. Nordlind, K., Sundstrom, E., & Bondesson, L. (1992). Inhibiting effects of serotonin antagonists on the proliferation of mercuric chloride stimulated human peripheral blood t lymphocytes. Int. Arch. Allergy Immunol. 97, 105-108.
54. Paxinos, G., & Watson, C. (1982). The Rat Brain in Stereotaxic Coordinates. Academic Press: New York.
55. Pellegrino, T., & Bayer, B. M. (1998). Modulation of immune cell function following fluoxetine administration in rats. Pharm. Biochem. Behav. 59, 151-157.
56. Pierpaoli, W., & Maestroni, G. J. (1978). Pharmacological control of the hormonally modulated immune response. II. Blockade of antibody production by a combination of drugs acting on neuroendocrine functions. Its prevention by gonadotropins and corticotrophin. Immunology 34, 419-430.
57. Pranzatelli, M. R. (1990). Evidence for involvement of 5-HT2 and 5-HT1C receptors in the behavioral effects of the 5-HT agonist 1-(2,5-dimethoxy-4-iodophenyl aminopropane)-2 (DOI). Neurosci. Lett. 115, 74-80.
58. Rader, R. K., Kahn, L. E., Anderson, G. D., Martin, C. L., Chinn, K. S., & Gregory, S. A. (1996). T cell activation is regulated by voltage-dependent and calcium-activated potassium channels. J. Immunol. 156, 1425-1430.
59. Reed, S. M., & Glick, J. W. (1991). Fluoxetine and reactivation of the herpes simplex virus. Am. J. Psychiatr. 148, 949-950.
60. Rinner, I., & Schauenstein, K. (1991). The parasympathetic nervous system takes part in the immunoneuroendocrine dialogue. J. Neuroimmunol. 34, 165-172.
61. Roszman, T. L., & Brooks, W. H. (1985). Neural modulation of immune function. J. Neuroimmunol. 10, 59-69.
62. Roudebush, R. E., & Bryant, H. U. (1993). Pharmacologic manipulation of a four day murine delayed type hypersensitivity model. Agents Actions 38, 116-121.
63. Sacerdote, P., Bianchi, M., Gaspani, L., & Panerai, A. E. (1999). Effects of tramadol and its enantiomers on Concanavalin-A induced-proliferation and NK activity of mouse splenocytes: Involvement of serotonin. Int. J. Immunopharmacol. 21, 727-734.
64. Seabrook, J. M., & Nolan, P. L. (1983). The vascular interaction of noradrenaline and 5-hydroxytryptamine. Eur. J. Pharm. 89, 131-135.
65. Silverman, D. H., Wu, H., & Karnovsky, M. (1985). Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem. Biophys. Res. Commun. 131, 1160-1167.
66. Sipos, M. L., Bauman, R. A., Widholm, J. J., and Kant, G. J. (2000). Behavioral effects of 8-OH-DPAT in chronically stressed male and female rats. Pharmacol. Biochem. Behav. 66, 403-411.
67. Slauson, D. O., Walker, C., Kristensen, F., Wang, Y., & De Weck, A. L. (1984). Mechanisms of serotonin-induced lymphocyte proliferation inhibition. Cell. Immunol. 84, 240-252.
68. Stein, C., Davidowa, H., and Albrecht, D. (2000). 5-HT(1A) receptor-mediated inhibition and 5-HT(2) as well as 5-HT(3) receptor-mediated excitation in different subdivisions of the rat amygdala [In Process Citation]. Synapse 38, 328-337.
69. 2 serotonergic receptor antagonists. J. Immunol. 137, 276-282.
70. Sternberg, E. M., Wedner, H. J., Leung, M. K., & Parker, C. W. (1987). Effect of serotonin (5-HT) and other monoamines on murine macrophages: Modulation of interferon-gamma induced phagocytosis. J. Immunol. 138, 4360-4365.
71. Strauss, U., Wittstock, U., Schubert, R., Teuscher, E., Jung, S., & Mix, E. (1996). Cicutoxin from Cicuta virosa - A new and potent potassium channel blocker in T lymphocytes. Biochem. Biophys. Res. Commun. 219, 332.
72. Tao, R., & Auerbach, S. B. (1994). Increased extracellular serotonin in rat brain after systemic or intraraphe administration of morphine. J. Neurochem. 63, 517-524.
73. 3H]ketanserin labeling of hydroxytryptamine2 (5-HT2) receptors in mammalian cells transfected with a rat 5HT2 cDNA: Evidence for multiple states and not multiple 5HT2 receptor subtypes. Mol. Pharmacol. 38, 594-598.
74. Van Harten, J. (1993). Clinical pharmacokinetics of selective serotonin reuptake inhibitors. Clin. Pharmacokinet. 24, 203-220.
75. Vitiello, B., & Stover, E. (1996). Psychopharmacology in HIV-positive patients: Research perspectives. PsychoPharmacol. Bull. 32, 293-297.
76. Voigt, J. P., Kienzle, F., Sohr, R., Rex, A., and Fink, H. (2000). Feeding and 8-OH-DPAT-related release of serotonin in the rat lateral hypothalamus. Pharmacol. Biochem. Behav. 65, 183-189.
77. 2B receptor: Evidence for species differences. J. Pharmacol. Exp. Ther. 276, 720-727.
78. Watts, S. W. (1996). Serotonin activates the mitogen-activated protein kinase pathway in vascular smooth muscle: Use of the mitogen-activated protein kinase kinase inhibitor PD098059. J. Pharmacol. Exp. Ther. 279, 1541-1550.
79. 1A receptors inhibit adrenocortical secretion. Neuroendocrinology 57, 272-281.
80. Yang, L. H., Callas, D., Herbert, J. M., & Fareed, J. (1996). Modulation of platelet function and vascular smooth muscle contractile actions by a novel, selective, highly potent 5-HT2 antagonist (SR46349). Thromb. Res. 81, 555-567.
81. Young, M. R., Kut, J. L., Coogan, M. P., Wright, M. A., Young, M. E., & Matthews, J. (1993). Stimulation of splenic T-lymphocyte function by endogenous serotonin and by low-dose exogenous serotonin. Immunology 80, 395-400.
82. Young, M. R. I., & Matthews, J. P. (1995). Serotonin regulation of T-cell subpopulations and of macrophage accessory function. Immunology 84, 148-152.