The serotonin analogue buspirone increases the function of PBMC from HIV-infected individuals in vitro

Scandinavian Journal of Infectious Diseases

Volumn 29, Issue 2, 1997, Pages 117-120

  Afzelius, Pia ^a   Nielsen, Susanne Dam ^a   Hofmann, Bo ^a   Nielsen, Jens Ole ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ANTIGEN; BUSPIRONE; CD4 ANTIGEN; CYCLIC AMP; INTERLEUKIN 2; MESSENGER RNA; MITOGENIC AGENT; SEROTONIN DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MESSENGER RNA SYNTHESIS; MONONUCLEAR CELL; SECOND MESSENGER; T LYMPHOCYTE;

EID: 0030943068     PISSN: 00365548     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365549709035870     Document Type: Article

References (16)

1. Ciobanu N, Welte K, Kruger G, Venuta S, Gold J, Feldman P, Wang C, Koziner B, Moore MAS, Safai B, Mertelmann R. Defective T cell response to PHA and mitogenic monoclonal antibodies in male homosexuals with acquired immunodeficiency syndrome and its in vitro correlation by interleukin 2. J Clin Immun 3: 332-340, 1983.
2. Hofmann B, Jakobsen KD, Ødum N, Dickmeiss E, Plaz P, Ryder LP, Pedersen C, Mathiesen L, Bygbjerg I, Faber V, Svejgaard A. HIV-induced immunodeficiency: relatively preserved phytohemagglutinin as opposed to decreased pokeweed mitogen responses may be due to possibly responses via CD2/phytohemagglutinin pathway. J Immun 142: 1874-1880, 1989.
3. Hofmann B, Nishanian P, Nguyen T, Liu M, Fahay JL. Restoration of T cell function in HIV infection by reduction of intracellular cAMP levels with adenosine analogues. AIDS 7: L659-664, 1993.
4. Lane HC, Depper JM, Greene WC, Whalen G, Waldmann TA, Fauci AS. Quantitative analysis of immune function in patients with the acquired immunodeficiency syndrome: evidence for a selective defect in soluble antigen recognition. N Engl J Med 313: 79-84, 1985.
5. Prince HE, Kermani-arab V, Fahey JL. Depressed interleukin 2 receptor expression in acquired immune deficiency and lymphadenopathysyndromes. J Immun 133: 1313-1317, 1984.
6. Clerici M, Stocks NI, Zajac RA, Boswell RN, Bernstein DC, Mann DL, Shearer GM, and Berzofsky JA. Interleukin-2 production used to detect antigenic peptide recognition by T helper lymphocytes from asymptomatic HIV-seropositive individuals. Nature 339: 383, 1989.
7. Maggi E, Mazzetti M, Ravina A, Annunziato F, De Carli M, Piccinni MP, Manetti R, Carbonari M, Pesce AM, Del Prete G, Romagnani S. Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 265: 244-248, 1994.
8. Meroni L Trabattoni D, Balotta C, Riva C, Gori A, Meroni M, Villa ML, Clerici M, Galli M. Evidence for type 2 cytokine production and lymphocyte activation in the early phases of HIV-1 infection. AIDS 10: L23-30, 1996.
9. Clerici M, Shearer GM. A TH1→TH2 switch is a critical step in the aetiology of HIV infection. Immun Today 14: 107-111, 1993.
10. Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahay JL. HIV proteins induce the inhibitory cAMP/protein kinase A pathway in normal T lymphocytes. Proc Natl Acad Sci USA 90: 6676-6680, 1993.
11. Nielsen SD, Nielsen JO, Hansen J-ES 1996. In vitro separation and expansion of CD4 lymphocytes from HIV-infected individuals without activation of HIV-infection. J Immun Meth (in press).
12. + T helper cell depletion occurs. J Clin Invest 82: 1908-1914, 1988.
13. Novak TJ, Rothenberg EV. cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells. Proc Natl Acad Sci USA 87: 9353-9357, 1990.
14. Krause DS, Deutsch C. Cyclic AMP inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected. J Immun 146: 2285-2294, 1991.
15. Aune TM, McGrath KM, Sarr T, Bombara MP, Kelley KA. Expression of 5HT1a receptors on activated human T cells. J Immun 151: 1175-1183, 1993.
16. Peroutka SJ. 5-Hydroxytryptamine receptors. Scand J Neurochem 60: 408-416, 1993.