An assessment of the acute effects of the serotonin releasers methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on immunity in rats

Immunopharmacology

Volumn 46, Issue 3, 2000, Pages 223-235

  Connor, Thomas J ^a   Kelly, John P ^a   Leonard, Brian E ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Cytokine; Fenfluramine; IFN ; IL 1 ; IL 10; IL 2; Immune system; Immunosuppression; Lymphocytes; MDA; MDMA; Serotonin releasers; TNF

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE DERIVATIVE; CYTOKINE; FENFLURAMINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; SEROTONIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE SYSTEM; IMMUNITY; LOCOMOTION; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

3,4-METHYLENEDIOXYAMPHETAMINE; ANIMALS; CONCANAVALIN A; CYTOKINES; FEMALE; FENFLURAMINE; IMMUNITY; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGENTS;

EID: 0033963433     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(99)00180-0     Document Type: Article

References (48)

1. Arase K., Sakaguchi T., Bray G.A. Effect of fenfluramine on sympathetic firing rate. Pharmacol. Biochem. Behav. 29:1988;675-680.
2. Bayer B.M., Mulroney S.E., Hernandez M.C., Ding X.Z. Acute infusions of cocaine result in time-and dose-dependent effects on lymphocyte responses and corticosterone secretion in rats. Immunopharmacology. 29:1995;19-28.
3. Beutler B. TNF, immunity and imflammatory disease: lessons of the past decade. J. Invest. Med. 43:1995;227-235.
4. Buczko W., DeGaetano G., Garattini S. Effect of fenfluramine on 5-hydroxytryptamine uptake and release by rat blood platelets. Br. J. Pharmacol. 53:1975;563-568.
5. Chu T., Kumagai Y., DiStefano E.W., Cho A.K. Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion. Biochem. Pharmacol. 51:1996;789-796.
6. Clancy J.J., Lorens S. Subchronic and chronic exposure to D-fenfluramine dose-dependently enhances splenic immune functions in young and old male Fischer-344 rats. Behav. Brain Res. 73:1996;355-358.
7. Clancy J. Jr., Petrovic L.M., Gordon B.H., Handa R.J., Campbell D.B., Lorens S.A. Effects of subchronic D-fenfluramine on splenic immune functions in young and old male and female Fischer 344 rats. Int. J. Immunopharmacol. 13:1991;1203-1212.
8. Connor T.J., McNamara M.G., Finn D., Currid A., O'Malley M., Redmond A.M., Kelly J.P., Leonard B.E. Acute 3,4-methylenedioxymethamphetamine (MDMA) administration produces a rapid and sustained suppression of immune function in the rat. Immunopharmacology. 38:1998;253-260.
9. Connor T.J., McNamara M.G., Kelly J.P., Leonard B.E. 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) administration produces dose-dependent neurochemical, endocrine and immune changes in the rat. Human Psychopharmacol. 14:1999;95-104.
10. Connor T.J., Dredge K., McNamara M., Kelly J.P., Leonard B.E. Immunomodulatory effects of 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy). Neuroimmunomodulation. 6:1999;211.
11. Connor, T.J., Kelly, J.P., Dredge, K., Leonard, B.E., Methylenedioxymethamphetamine (MDMA; Ecstasy) provokes a suppression of IL-1β and TNF-α secretion following an in vivo challenge with lipopolysaccharide in rats. Toxicol. Appl. Pharmacol., 2000, (Submitted).
12. Cunnick J.E., Lysle D.T., Kucinski B.J., Rabin B.S. Evidence that shock-induced immune suppression is mediated by adrenal hormones and peripheral beta-adrenergic receptors. Pharmacol. Biochem. Behav. 36:1990;645-651.
13. Dahl C.B., Gotesta K.G. Lack of self-administration of different fenfluramine isomers in rats. Addict Behav. 14:1989;239-247.
14. DeGroote D., Zangerle P.F., Gevaert Y., Fassotte M.F., Beguin Y., Noizat-Pirenne F., Pirenne, Gathy R., Lopez M., Dehart I., Igot D., Baudrihaye M., Delacroix D., Franchimont P.et al. Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood: I. Comparison with isolated PBMC stimulation. Cytokine. 4:1992;239-248.
15. Dinarello, C.A., Interleukin-1. In: Thompson A. (Ed.), The Cytokine Handbook, 2nd edn., Academic Press, 1994, 31-56.
16. Elenkov I.J., Hasko G., Kovacs K.J., Vizi E.S. Modulation of lipopolysaccharide-induced tumor necrosis factor-alpha production by selective alpha- and beta-adrenergic drugs in mice. J. Neuroimmunol. 61:1995;123-131.
17. Fasanmade A.A., Jusko W.J. Optimizing whole blood lymphocyte in the rat. J. Immunol. Methods. 184:1995;163-167.
18. Fleshner M., Brennan F.X., Nguyen K., Watkins L.R., Maier S.F. RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response. Am. J. Physiol. 271:1996;R1344-R1352.
19. Friedman E.M., Irwin M.R. Modulation of immune cell function by the autonomic nervous system. Pharmacol. Ther. 74:1997;27-38.
20. Grob S.C., Russell E.P., Chang L., Ernst T. Psychobiologic effects of 3,4-methylenedioxymethamphetamme in humans: Methodological considerations and preliminary observations. Behav. Brain Res. 73:1996;103-107.
21. Gudelsky G.A., Nash J.F. Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamme: Implications for serotonin-dopamine interactions. J. Neurochem. 66:1996;243-249.
22. Hegadoren K.M., Martin-Iverson M.T., Baker G. Comparative behavioural and neurochemical studies with a psychomotor stimulant, an hallucinogen and 3,4-methylenedioxy analogues of amphetamine. Psychopharmacology (Berl). 118:1995;295-304.
23. House R.V., Thomas P.T., Bhargava H.N. Selective modulation of immune function resulting from in vitro exposure to methylenedioxymetharnphetamine (Ecstasy). Toxicology. 96:1995;59-69.
24. Kankaanpaa A., Meririnne E., Lillsunde P., Seppala T. The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens. Pharmacol. Biochem. Behav. 59:1998;1003-1009.
25. Kelliher P., Nolan Y.M., Dredge K., Connor T.J., Kelly J.P., Leonard B.E. Effects of a variety of stressors on leucocyte subpopulations in the rat. Neuroimmunomodulation. 5:1998;24.
26. Kut J.L., Young M.R.I., Crayton J.W., Wright M.A., Young M.E. Regulation of murine T-lymphocyte function by spleen cell derived and exogenous serotonin. Immunopharmacol. Immunotoxicol. 14:1992;783-796.
27. Mathews H.L., Lorens S.A., Clancy J. Jr. Effect of D-fenfluramine on the local immune response to the opportunistic microbial pathogen Candida albicans. Behav. Brain Res. 73:1996;369-374.
28. McGarvey, C.M., The effects of pharmacological modulation of the serotonergic system on some neuroendocrine, neurochemical and behavioural parameters in the rat. PhD Thesis, National University of Ireland, 1995.
29. McGarvey C., Kelly J., O'Donnell J.M., Leonard B.E. Neuroendocrine and behavioural effects of the serotonin releasers 3,4-methylenedioxymetamphetamine and fenfluramine in rats. J. Serotonin Res. 4:1995;257-265.
30. McNamara M.G., Kelly J.P., Leonard B.E. Thermoregulatory and locomoter activity responses of 3,4-methylenedioxymethamphetamine (MDMA) in male and female rats. J. Serotonin Res. 4:1995;275-282.
31. McNamara M.G., Kelly J.P., Leonard B.E. The effect of acute MDMA administration on body temperature, serum corticosterone and neurotransmitter concentrations in male and female rats. Hum. Psychopharmacol. 10:1995;373-383.
32. Mellon R.D., Bayer B.M. The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses. J. Pharmacol. Expt. Ther. 288:1999;635-642.
33. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7:1989;145-173.
34. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine T-helper clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:1986;2348-2357.
35. Pacifici R., Di Carlo S., Bacosti A., Zuccaro P. Immunotoxicokinetics of MDMA in mice. Eur. Neuropsychopharmacol. 9:1999;s343. (Suppl. 5).
36. Pallardy M. Testing strategies in immunotoxicology. Toxicol. Lett. 95:1998;12.
37. Pezzone M.A., Rush K.A., Kusnecov A.W., Wood P.G., Rabin B.S. Corticosterone-independent alteration of lymphocyte mitogenic function by amphetamine. Brain Behav. Immunol. 6:1992;293-299.
38. Pinder R.M., Brogden R.N., Sawyer P.R., Speight T.M., Avery G.S. Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. Drugs. 10:1975;241-323.
39. Popov N., Pohle W., Rosier V., Matthies H. Regionale verteilung von gamma-aminobuttersaure, glutaminsaure, asparaginsaure, dopamin, noradreanlin and serotonin in rattenhirn. Acta Med. Biol. Germ. 18:1967;695-702.
40. Rudnick G., Wall S.C. The molecular mechanism of "Ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: Serotonin transporters are targets for MDMA-induced serotonin release. Proc. Natl. Acad. Sci. USA. 89:1992;1817-1821.
41. Seyfried C.A., Adam G., Greve T. An automated direct-injection HPLC method for the electrochemical/fluorometric quantitation of monoamines and related compounds optimized for the screening of large numbers of animals. Biomed. Chromatogr. 1:1986;78-88.
42. Stone D.M., Stahl D.C., Hanson G.R., Gibb J.W. The effects of 3,4-methylenedioxymethamphetamme and 3,4-methylenedioxyamphetamine on monoaminergic systems in rat brain. Eur. J. Pharmacol. 128:1986;41-48.
43. Tracey, K.J., Tumor necrosis factor-alpha. In: Thompson, A. (Ed.), The Cytokine Handbook, 2nd edn., Academic Press, 1994, pp. 289-304.
44. Wichems C.H., Hollingsworth C.K., Bennett B.A. Release of serotonin induced by 3,4-lethylenedioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe eurons: further evidence for calcium-independent mechanisms of release. Brain. Res. 695:1995;10-18.
45. Wong G.H.W., Goeddel D.V. Tumor necrosis factor alpha and beta inhibit virus replication and synergize with interferons. Nature. 323:1986;819-822.
46. World Health Organisation Principles and methods for assessing direct immunotoxicity associated with exposure to chemicals. Environmental Health Criteria. 180:1996.
47. Yeh S.Y., Hsu F.L. The neurochemical and stimulatory effects of putative metabolites of 3,4-lethylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats. Pharmacol. Biochem. Behav. 39:1991;787-790.
48. Zangerle P.F., DeGroote D., Lopez M., Meuleman R.J., Vrindts Y., Fauchet F., Dehart I., Jadoul M., Radoux D., Franchimont P. Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood: II. Application to rheumatoid arthritis and osteoarthritis. Cytokine. 4:1992;568-575.