Effects of antidepressants on intracellular Ca2+ mobilization in CHO cells transfected with the human 5-HT2C receptors

Biological Psychiatry

Volumn 39, Issue 12, 1996, Pages 1000-1008

  Akiyoshi, Jotaro ^a   Isogawa, Koichi ^a   Yamada, Kenji ^a   Nagayama, Haruo ^a   Fujii, Isao ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

5 HT1A; 5 HT2C; Agonists; Antagonists; Antidepressants; Serotonin receptor

Indexed keywords

AMITRIPTYLINE; AMOXAPINE; ANTIDEPRESSANT AGENT; CALCIUM; IMIPRAMINE; KETANSERIN; MESULERGINE; MIANSERIN; NORTRIPTYLINE; RITANSERIN; SEROTONIN RECEPTOR; SPIPERONE;

ANIMAL CELL; ARTICLE; FEMALE; HAMSTER; NONHUMAN; OVARY CELL; PRIORITY JOURNAL;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CALCIUM; CALCIUM CHANNELS; CHO CELLS; CRICETINAE; ERGOLINES; HUMANS; INTRACELLULAR FLUID; MIANSERIN; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0029952637     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(95)00309-6     Document Type: Article

References (33)

1. 2 receptors stimulation. Mol Pharmacol 42:349-355.
2. 1C receptor density and mRNA levels in choroid plexus epithelial cells after treatment with mianserin and (-)-1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. Mol Pharmacol 44:725-730.
3. Berendsen HHG, Broekkamp CLE (1990): Behavioral evidence for functional interactions between 5-HT receptor subtypes in rats and mice. Br J Pharmacol 101:667-673.
4. Boddeke HWGM, Hoffman BJ, Palacios JM, Knot H, Hoyer D (1993): Characterization of functional response in A9 cells transfected with cloned rat 5-HT1C receptors. Naunyn-Schmiedeberg's Arch Pharmacol 347:119-124.
5. Brogden RN, Heel RC, Speight TM, Avery GS (1981): Trazodone: A review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs 21:401-429.
6. 2 receptor mRNA in rat frontal cortex. J Neurochem 61:1270-1276.
7. Caroll BJ, Curtis GC, Mendels J (1976): Neuroendocrine regulation in depression: II. Discrimination of depressed from non-depressed patients. Arch Gen Psychiatry 138:1218-1221.
8. Chen C, Okayama H (1987): High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752.
9. Conn PJ, Sanders-Bush E (1987): Relative efficacies of piperazine at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther 242:552-557.
10. Conn PJ, Sanders-Bush E, Hoffmann BJ, Hartig PR (1986): A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc Natl Acad Sci USA 83: 4086-4088.
11. 2 receptor sites. J Biol Chem 260:7603-7608.
12. Hadcock JR, Malbon CC (1991): Regulation of receptor expression by agonists: Transcriptional and post-transcriptional control. Trends Neurosci 14:242-247.
13. Hall H, Ogren SO (1981): Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol 70:393-397.
14. Holmes MC, French KL, Seckl JR (1995): Modulation of serotonin and corticosteroid gene expression in the rat hippocampus with circadian rhythm and stress. Mol Brain Res 28:186-192.
15. 1C receptors. Trends Pharmacol Sci 9:89-94.
16. Jenck F, Moreau J-L, Mutel V, Martin JR, Haefely WE (1993): Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur J Pharmacol 231:223-229.
17. Julius D, MacDermott AB, Axel R, Jessell TM (1988): Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241:558-564.
18. Lubbert H, Huffman BJ, Snutch TP, Van Dyke T, Levine AJ (1987): cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci USA 84:4332-4336.
19. Maj J (1981): Serotonergic mechanisms of antidepressant drugs. Pharmacopsychiatry 14:35-40.
20. Matthes H, Boschert U, Amlaiky N, Grailhe R, Plassat JL, Muscatelli F, Mattei MG, Hen R (1993) Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: Cloning, functional expression and chromosomal localization. Mol Pharmacol 43:313-319.
21. Molineaux SM, Jessell TM, Axel R, Julius D (1989): 5-HT1C receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci USA 86:6793-6797.
22. Monsma FJ Jr, Shen Y, Ward RP, Hamblin MW, Sibley DR (1993): Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 43:320-327.
23. Pazos A, Hoyer D, Palacios JM (1985): The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site. Eur J Pharmacol 106:539-546.
24. Peroutka SJ (1993): 5-hydroxytryptamine receptors. J Neurochem 60:408-416.
25. 2C receptor. Mol Brain Res. 23:163-178.
26. 2 receptor mRNA levels. Eur J Pharmacol 207:169-172.
27. Saltzman AG, Morse B, Whitman MM, Ivanshchenko Y, Jaye M, Felder S (1991): Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochem Biophys Res Commun 181:1469-1478.
28. 1C receptor reserve in choroid plexus masks receptor subsensitivity. J Pharmacol Exp Ther 252:984-988.
29. Shen Y, Monsma FJ Jr, Metcalf MA, Jose PA, Hamblin MW, Sibley DR (1993): Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem 268:18200-18204.
30. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallmann MF, Julius D (1995): Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature 374: 542-546.
31. Tohda M, Takasu T, Nomura Y (1989): Effects of antidepressants on serotonin-evoked current in Xenopus oocyte injected with rat brain m-RNA. Eur J Pharmacol 186:57-63.
32. 125I-Lysergic acid diethyamide binds to a novel serotonergic site on rat choroid plexus epithelial cells. J Neurosci 5:3178-3183.
33. Yates M, Leake A, Candy JM, Fairbairn AF, McKeith IG, Ferrier IN (1990): 5HT2 receptors changes in major depression. Biol Psychiatry 27:489-496.