The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73

European Journal of Biochemistry

Volumn 269, Issue 22, 2002, Pages 5649-5658

  Pavlova, Alona ^a   Estrada, Sergio ^b   Björk, Ingemar ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cathepsins; Cystatin; Cysteine proteases; Papain; Second binding loop

Indexed keywords

ASPARAGINE; CATHEPSIN B; CATHEPSIN L; CYSTATIN B; CYSTEINE PROTEINASE INHIBITOR; GLUTAMINE; LEUCINE; PAPAIN; PROLINE; PROTEINASE; STEFIN A;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG BINDING; ENERGY; ENZYME BINDING; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; HUMAN; MUTATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS;

ANIMALS; ASPARAGINE; CATHEPSIN B; CATHEPSINS; CHICKENS; CRYSTALLOGRAPHY, X-RAY; CYSTATINS; CYSTEINE ENDOPEPTIDASES; GLUTAMINE; KINETICS; LEUCINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE;

EID: 0036436926     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03273.x     Document Type: Article

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