The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L

Biochemistry

Volumn 37, Issue 20, 1998, Pages 7551-7560

  Estrada, Sergio ^a   Nycander, Maria ^a   Hill, Nikki J ^b   Craven, C Jeremy ^b   Waltho, Jonathan P ^b   Björk, Ingemar ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; GLUTAMINE; GLYCINE; PAPAIN; SERINE; STEFIN A;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY;

BINDING, COMPETITIVE; CATHEPSIN B; CATHEPSINS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; CYSTATINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOPEPTIDASES; GLYCINE; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; PAPAIN; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 0032546591     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980026r     Document Type: Article

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