Fimbria-fornix lesion does not affect APP levels and amyloid deposition in the hippocampus of APP+PS1 double transgenic mice

Experimental Neurology

Volumn 177, Issue 2, 2002, Pages 565-574

  Liu, Li ^a   Ikonen, Sami ^a   Tapiola, Tero ^a   Tanila, Heikki ^a,b   Van Groen, Thomas ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alzheimer's disease; Amyloid deposition; Amyloid precursor protein; Cholinergic system; Fimbria fornix lesion; Hippocampus; Presenilin; Transgenic mice

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BIOLOGICAL MARKER; PRESENILIN 1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FORNIX; BRAIN INJURY; BRAIN LEVEL; CHEMICAL ANALYSIS; CONTROLLED STUDY; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MOUSE; NERVE TRACT; NERVE TRANSECTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN METABOLISM; TRANSGENIC MOUSE;

EID: 0036433445     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.8015     Document Type: Article

References (45)

1. Apelt, J., R. Schliebs, M. Beck, S. Rossner, and V. Bigl. 1997. Expression of amyloid precursor protein mRNA isoforms in rat brain is differentially regulated during postnatal maturation and by cholinergic activity. Int. J. Dev. Neurosci. 15: 95-112.
2. Beach, T. G., P. E. Potter, Y. M. Kuo, M. R. Emmerling, R. A. Durham, S. D. Webster, D. G. Walker, L. I. Sue, S. Scott, K. J. Layne, and A. E. Roher. 2000. Cholinergic deafferentation of the rabbit cortex: A new animal model of Abeta deposition. Neurosci. Lett. 283: 9-12.
3. Beeson, J. G., E. R. Shelton, H. W. Chan, and F. H. Gage. 1994. Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain. J. Comp. Neurol. 342: 69-77.
4. Berger-Sweeney, J., N. A. Stearns, S. L. Murg, L. R. Floerke-Nashner, D. A. Lappi, and M. G. Baxter. 2001. Selective immunolesions of cholinergic neurons in mice: Effects on neuroanatomy, neurochemistry, and behavior. J. Neurosci. 21: 8164-8173.
5. Blaker, S. N., D. M. Armstrong, and F. H. Gage. 1988. Cholinergic neurons within the rat hippocampus: Response to fimbria-fornix transection. J. Comp. Neurol. 272: 127-138.
6. Boncristiano, S., M. E. Calhoun, P. H. Kelly, M. Pfeifer, L. Bondolfi, M. Stalder, A. L. Phinney, D. Abramowski, C. Sturchler-Pierrat, A. Enz, B. Sommer, M. Staufenbiel, and M. Jucker. 2002. Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis. J. Neurosci. 22: 3234-3243.
7. Borchelt, D. R., T. Ratovitski, J. van Lare, M. K. Lee, V. Gonza-les, N. A. Jenkins, N. G. Copeland, D. L. Price, and S. S. Sisodia. 1997. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19: 939-945.
8. Braak, H., and E. Braak. 1991. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berlin) 82: 239-259.
9. Buxbaum, J. D., E. H. Koo, and P. Greengard. 1993. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc. Natl. Acad. Sci. USA 90: 9195-9198.
10. Buxbaum, J. D., M. Oishi, H. I. Chen, R. Pinkas-Kramarski, E. A. Jaffe, S. E. Gandy, and P. Greengard. 1992. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA 89: 10075-10078.
11. Caputi, A., S. Barindelli, L. Pastorino, M. Cimino, J. D. Bux-baum, F. Cattabeni, and M. Di Luca. 1997. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C. J. Neurochem. 68: 2523-2529.
12. Cummings, J. L., H. V. Vinters, G. M. Cole, and Z. S. Khachaturian. 1998. Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 51: S2-17.
13. Evans, D. A., H. H. Funkenstein, M. S. Albert, P. A. Scherr, N. R. Cook, M. J. Chown, L. E. Hebert, C. H. Hennekens, and J. O. Taylor. 1989. Prevalence of Alzheimer's disease in a community population of older persons: Higher than previously reported. JAMA 262: 2551-2556.
14. Farber, S. A., R. M. Nitsch, J. G. Schulz, and R. J. Wurtman. 1995. Regulated secretion of beta-amyloid precursor protein in rat brain. J. Neurosci. 15: 7442-7451.
15. Fonnum, F. 1975. A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24: 407-409.
16. Francis, P. T., A. M. Palmer, M. Snape, and G. K. Wilcock. 1999. The cholinergic hypothesis of Alzheimer's disease: A review of progress. J. Neurol. Neurosurg. Psychiatry 66: 137-147.
17. Franklin, K. B. J., and G. Paxinos. 1996. The Mouse Brain in Stereotaxic Coordinates. Academic Press, San Diego.
18. Gabuzda, D., J. Busciglio, and B. A. Yankner. 1993. Inhibition of beta-amyloid production by activation of protein kinase C. J. Neurochem. 61: 2326-2329.
19. Gage, F. H., A. Bjorklund, and U. Stenevi. 1983. Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents. Brain Res. 268: 27-37.
20. Garvey, C. M., W. R. Panje, and H. T. Hoffman. 2001. The 'parachute' bolster technique for securing intraoral skin grafts. Ear Nose Throat J. 80: 720-723.
21. Gasser, U. E., and A. R. Dravid. 1987. Noradrenergic, serotonergic, and cholinergic sprouting in the hippocampus that follows partial or complete transection of the septohippocampal pathway: Contributions of spared inputs. Exp. Neurol. 96: 352-364.
22. Goss, J. R., and D. G. Morgan. 1995. Enhanced glial fibrillary acidic protein RNA response to fornix transection in aged mice. J. Neurochem. 64: 1351-1360.
23. Haass, C., E. H. Koo, A. Mellon, A. Y. Hung, and D. J. Selkoe. 1992. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments. Nature 357: 500-503.
24. Hardy, J. 1997. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20: 154-159.
25. Hung, A. Y., C. Haass, R. M. Nitsch, W. Q. Qiu, M. Citron, R. J. Wurtman, J. H. Growdon, and D. J. Selkoe. 1993. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J. Biol. Chem. 268: 22959-22962.
26. Jensen, M., T. Hartmann, B. Engvall, R. Wang, S. N. Uljon, K. Sennvik, J. Naslund, F. Muehlhauser, C. Nordstedt, K. Beyreuther, and L. Lannfelt. 2000. Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems. Mol. Med. 6: 291-302.
27. Leanza, G. 1998. Chronic elevation of amyloid precursor protein expression in the neocortex and hippocampus of rats with selective cholinergic lesions. Neurosci. Lett. 257: 53-56.
28. Lin, L., C. J. LeBlanc, T. W. Deacon, and O. Isacson. 1998. Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system. NeuroReport 9: 547-552.
29. Liu, L., S. Ikonen, T. Heikkinen, T. Tapiola, T. van Groen, and H. Tanila. 2002. The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice. Exp. Neurol. 173: 196-204.
30. Mori, F., C. C. Lai, F. Fusi, and E. Giacobini. 1995. Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. NeuroReport 6: 633-636.
31. Muller, D. M., K. Mendla, S. A. Farber, and R. M. Nitsch. 1997. Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain. Life Sci. 60: 985-991.
32. Nitsch, R. M., B. E. Slack, R. J. Wurtman, and J. H. Growdon. 1992. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258: 304-307.
33. Price, D. L., and S. S. Sisodia. 1998. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21: 479-505.
34. Price, D. L., R. E. Tanzi, D. R. Borchelt, and S. S. Sisodia. 1998. Alzheimer's disease: Genetic studies and transgenic models. Annu. Rev. Genet. 32: 461-493.
35. Ramirez, M. J., K. E. Heslop, P. T. Francis, and M. Rattray. 2001. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain Res. 907: 222-232.
36. Ramirez, M. J., R. M. Ridley, H. F. Baker, C. J. Maclean, W. G. Honer, and P. T. Francis. 2001. Chronic elevation of amyloid precursor protein in the neocortex or hippocampus of marmosets with selective cholinergic lesions. J. Neural Transm. 108: 809-826.
37. Roberson, M. R., and L. E. Harrell. 1997. Cholinergic activity and amyloid precursor protein metabolism. Brain Res. Brain Res. Rev. 25: 50-69.
38. Rossner, S., U. Ueberham, R. Schliebs, J. R. Perez-Polo, and V. Bigl. 1998. The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Prog. Neurobiol. 56: 541-569.
39. Rossner, S., U. Ueberham, J. Yu, L. Kirazov, R. Schliebs, J. R. Perez-Polo, and V. Bigl. 1997. In vivo regulation of amyloid precursor protein secretion in rat neocortex by cholinergic activity. Eur. J. Neurosci. 9: 2125-2134.
40. Savage, M. J., S. P. Trusko, D. S. Howland, L. R. Pinsker, S. Mistretta, A. G. Reaume, B. D. Greenberg, R. Siman, and R. W. Scott. 1998. Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18: 1743-1752.
41. Selkoe, D. J. 1997. Alzheimer's disease: Genotypes, phenotypes, and treatments. Science 275: 630-631.
42. Shoji, M., T. E. Golde, J. Ghiso, T. T. Cheung, S. Estus, L. M. Shaffer, X. D. Cai, D. M. McKay, R. Tintner, B. Frangione, et al. 1992. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 258: 126-129.
43. Wallace, W., S. T. Ahlers, J. Gotlib, V. Bragin, J. Sugar, R. Gluck, P. A. Shea, K. L. Davis, and V. Haroutunian. 1993. Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation. Proc. Natl. Acad. Sci. USA 90: 8712-8716.
44. Wallace, W. C., V. Bragin, N. K. Robakis, K. Sambamurti, D. VanderPutten, C. R. Merril, K. L. Davis, A. C. Santucci, and V. Haroutunian. 1991. Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Res. Mol. Brain Res. 10: 173-178.
45. Wolf, B. A., A. M. Wertkin, Y. C. Jolly, R. P. Yasuda, B. B. Wolfe, R. J. Konrad, D. Manning, S. Ravi, J. R. Williamson, and V. M. Lee. 1995. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells. J. Biol. Chem. 270: 4916-4922.