Site-selective N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations

Neurobiology of Learning and Memory

Volumn 78, Issue 2, 2002, Pages 347-364

  Willmore, Catherine B ^a   Bespalov, Anton Y ^b   Beardsley, Patrick M ^c  

^a UNIVERSITY OF MARYLAND   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

AMPA receptor; Complex discrimination; Counting behavior; Fixed Consecutive Number; Glycine site; NMDA receptor; NR2B subunit; Working memory

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CYCLOSERINE; DIZOCILPINE; ELIPRODIL; GLUTAMATE RECEPTOR; GLYCINE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PROTEIN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; DISCRIMINATION LEARNING; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; INSTRUMENTAL CONDITIONING; MALE; MEMORY; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; RAT; REINFORCEMENT; TASK PERFORMANCE; WORKING MEMORY;

EID: 0036433345     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1006/nlme.2002.4077     Document Type: Article

References (102)

1. Asztely, F., & Gustafsson, B. (1996). Ionotropic glutamate receptors: Their possible role in the expression of hippocampal synaptic plasticity. Molecular Neurobiology, 12, 1-11.
2. Aultman, J. M., & Moghaddam, B. (2001). Distinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinically relevant task. Psychopharmacology, 153, 353-364.
3. Aura, J., & Riekkinen, P., Jr. (2000). Pre-training blocks the improving effect of tetrahydroaminoacridine and D-cycloserine on spatial navigation performance in aged rats. European Journal of Pharmacology, 390, 313-318.
4. Balster, R. L., Nicholson, K. L., & Sanger D. J. (1994). Evaluation of the reinforcing effects of eliprodil in rhesus monkeys and its discriminative stimulus effects in rats. Drug & Alcohol Dependence, 35, 211-216.
5. Bashir, Z. I., Tam, B., & Collingridge, G. L. (1990). Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP. Neuroscience Letters, 108, 261-266.
6. Baxter, M. G., Lanthorn, T. H., Frick, K. M., Golski, S, Wan, R. Q., & Olton, D. S. (1994). D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiology of Aging, 15, 207-213.
7. Bliss T. V. (1999). Young receptors make smart mice. Nature, 401, 25-27.
8. Brannon, E. M. (1998). Ordering of the numerosities 1 to 9 by monkeys. Science, 282, 746-749.
9. Broadbent, D. E., Church, R., Meck, W., & Rakitin, B. C. (1993). Quantitative relationships between timing and counting. In S. T. Boysen, & E. J. Capaldi (Eds.), The Development of Numerical Competence: Animal and Human Models (pp. 171-187). Hillsdale, NJ: Erlbaum.
10. Buller, A. L., Larson, H. C., Schneider, B. E., Beaton, J. A., Morrisett, R. A., & Monaghan, D. T. (1994). The molecular basis of NMDA receptor subtypes: Native receptor diversity is predicted by subunit composition. Journal of Neuroscience, 14, 5471-5484.
11. Chazot, P. L. (2000). CP-101606 by Pfizer, Inc. Current Opinions of Investigational Drugs, 1, 370-374.
12. Chazot, P. L., Coleman, S. K., Cik, M., & Stephenson, F. A. (1994). Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. Journal of Biological Chemistry, 269, 24403-24409.
13. 3H]MDL 105,519 binds with equal high affinity to both assembled and unassembled NR1 subunits of the NMDA receptor. European Journal of Pharmacology, 353, 137-140.
14. Chen, L., Cooper, N. G., & Mower, G. D. (2000). Developmental changes in the expression of NMDA receptor subunits (NR1, NR2A, NR2B) in the cat visual cortex and the effects of dark rearing. Brain Research: Molecular Brain Research, 78, 196-200.
15. Chenard, B. L., Shalaby, I. A., Koe, B. K., Ronau, R. T., Butler, T. W., Prochniak, M. A., Schmidt, A. W., & Fox, C. B. (1991). Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds. Journal of Medicinal Chemistry, 34, 3085-3090.
16. 3H](+)-3-PPP to sigma binding sites in rat brain. Neuroscience Letters, 116, 190-193.
17. Clissold, D. B., Karbon, E. W., Ferkany, J. W., Hartman, T., & Pontecorvo, M. J. (1992). Effects of strychnine insensitive glycine receptor antagonists and sigma agents on working memory performance: Comparison with dizocilpine and scopolamine. Behavioral Pharmacology, 3, 393-402.
18. Colquhoun, D., (1971). Lectures on biostatistics: An Introduction to Statistics with Applications in Biology and Medicine. Oxford, UK: Clarendon Press.
19. Cooke, M. F., Fisher, A., Thompson, I. D. & Stone, T. W. (1996). Interactions between ifenprodil and dizocilpine on mouse behavior in models of anxiety and working memory. European Neuropsychopharmacology, 6, 311-316.
20. Danysz, W., & Parsons, C. (1998) Glycine and N-methyl-D-aspartate receptors: Physiological significance and possible therapeutic applications. Pharmacology Review, 50, 597-664.
21. 3H]norepinephrine release in rat hippocampal slices. Neuropharmacology, 34, 141-147.
22. Doyle, K., Feerick, S., Kirkby, D. L., Eddleston, A., & Higgins G. A. (1998). Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short term memory and on overt behaviour. Behavioural Pharmacology, 9, 671-681.
23. Eichenbaum, H., & Cohen, N. (2001). From Conditioning to Conscious Recollection. Oxford, UK: University Press.
24. Filliat, P., Pernot-Marino, I., Baubichon, D., & Lallement, G. (1998). Behavioral effects of NBQX, a competitive antagonist of the AMPA receptors. Pharmacology, Biochemistry and Behavior, 59, 1087-1092.
25. Fishkin, R. J., Ince, E. S., Carlezon, W. A., Jr., & Dunn R. W. (1993). D-cycloserine attenuates scopolamine-induced learning and memory deficits in rats. Behavioral & Neural Biology, 59, 150-157.
26. Flood, J. F., Morley, J. E., & Lanthorn, T. H. (1992). Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor. European Journal of Pharmacology, 221, 249-254.
27. Foster, A. C., & Kemp, J. A. (1989). HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site. Journal of Neuroscience, 9, 2191-2196.
28. Fujita, H., Sato, K., Wen, T. C., Peng, Y., & Sakanaka, M. (1999). Differential expressions of glycine transporter 1 and three glutamate transporter mRNA in the hippocampus of gerbils with transient forebrain ischemia. Journal of Cerebral Blood Flow and Metabolism, 19, 604-615.
29. Fuster, J. M. (1997). Network memory. Trends in Neuroscience, 20, 451-459.
30. Galbicka, G., Kautz, M. A., & Jagers, T. (1994). Behavioral effects of enantiomers of dizocilpine under two "counting" procedures in rats. Pharmacology, Biochemistry and Behavior, 49, 943-948.
31. Gilad, G. M., & Gilad V. H. (1991). Polyamines can protect against ischemia-induced nerve cell death in gerbil forebrain. Experimental Neurology, 111, 349-355.
32. Goldman-Rakic, P. S. (1999) The "psychic" neuron of the cerebral cortex. Annals of the New York Academy of Science, 868, 13-26.
33. Hampson, R. E., Rogers, G., Lynch, G., & Deadwyler, S. A. (1998). Facilitative effects of the ampakine CX516 on short-term memory in rats: Enhancement of delayed-nonmatch-to-sample performance. Journal of Neuroscience, 18, 2740-2747.
34. Heynen, A. J., Quinlan, E. M., Bae, D. C., & Bear, M. F. (2000). Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo. Neuron, 28, 527-536.
35. Honer, M., Benke, D., Laube, B., Kuhse, J., Heckendorn, R., Allgeier, H., Angst, C., Monyer, H., Seeburg, P. H., Betz, H., & Mohler, H. (1998). Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors. Journal of Biological Chemistry, 273, 11158-11163.
36. Izquierdo, I., & Medina, J. H. (1995). Correlation between the pharmacology of long-term potentiation and the pharmacology of memory. Neurobiology of Learning and Memory, 63, 19-32.
37. Johnson, J. W., & Ascher, P. (1987). Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325, 529-531.
38. Kapus, G., Szekely, J. I., Durand, J., Ruiz, A., & Tarnawa, I. (2000). AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations. Brain, 52, 511-517.
39. Kemp, J. A., & Leeson, P. D. (1993.) The glycine site of the NMDA receptor - Five years on. Trends in Pharmacologic Sciences, 14, 20-25.
40. Kennedy, M. B. (1999). On beyond LTP: Long-term potentiation. Learning and Memory, 6, 417-421.
41. Kleckner, N. W., & Dingledine, R. (1988). Requirement for glycine in activation of NMDA receptors expressed in Xenopus oocytes. Science, 214, 835-837.
42. Laurie, D. J., Bartke, I., Schoepfer, R., Naujoks, K., & Seeburg, P. H. (1997). Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies. Brain Research: Molecular Brain Research, 51, 23-32.
43. Lees, G. J. (2000). Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders. Drugs, 59, 33-78.
44. Li, H. B., Matsumoto, K., Yamamoto, M., & Watanabe, H. (1997). NMDA but not AMPA receptor antagonists impair the delay-interposed radial maze performance of rats. Pharmacology, Biochemistry & Behavior, 58, 249-253.
45. Lu, Y., & Wehner J. M. (1997). Enhancement of contextual fear-conditioning by putative (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-D-aspartate (NMDA) receptor antagonists in DBA/2J mice. Brain Research, 768, 197-207.
46. Lynch, D. R., Anegawa, N. J., Verdoorn, T., & Pritchett, D. B. (1994). N-methyl-D-aspartate receptors: Different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents. Molecular Pharmacology, 45, 540-545.
47. Lynch, G. (1998). Memory and the brain: Unexpected chemistries and a new pharmacology. Neurobiology of Learning & Memory, 70, 82-100.
48. MacDermott, A. B., Role, L. W., & Siegelbaum, S. A. (1999). Presynaptic ionotropic receptors and the control of transmitter release. Annual Reviews of Neuroscience, 22, 443-485.
49. Martinez, J. L., Jr, & Derrick, B. E. (1996). Long-term potentiation and learning. Annual Reviews of Psychology, 47, 173-203.
50. Matsuoka, N., & Aigner, T. G. (1996). D-cycloserine, a partial agonist at the glycine site coupled to N-methyl-D-aspartate receptors, improves visual recognition memory in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics, 278, 891-897.
51. Matsuoka, N., & Aigner, T. G. (1996). The glycine/NMDA receptor antagonist HA-966 impairs visual recognition memory in rhesus monkeys. Brain Research, 731, 72-78.
52. Monahan, J. B., Handelmann, G. E., Hood, W. F., & Cordi, A. A. (1989). D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats. Pharmacology, Biochemistry, and Behavior, 34, 649-653.
53. Mondadori, C., Borkowski, J., & Gentsch, C. (1996). The memory-facilitating effects of the competitive NMDA-receptor antagonist CGP 37849 are steroid-sensitive, whereas its memory-impairing effects are not. Psychopharmacology, 124, 380-383.
54. Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994). Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron, 12, 529-540.
55. Myhrer, T. (1998). Restored cognitive function in rats with combined denervations in the temporal region: Neurochemical Aspects. Pharmacology, Biochemistry, and Behavior, 62, 683-688.
56. Nicoll, R. A., Kauer, J. A., & Malenka, R. C. (1988). The current excitement in long-term potentiation. Neuron, 1, 97-103.
57. Nicoll, R. A., & Malenka, R. C. (1999). Expression mechanisms underlying NMDA receptor-dependent long-term potentiation. Annals of the New York Academy of Sciences, 868, 515-525.
58. Ohno, M., & Watanabe, S. (1996). D-cycloserine, a glycine site agonist, reverses working memory failure by hippocampal muscarinic receptor blockade in rats. European Journal of Pharmacology, 318, 267-271.
59. Okabe, S., Collin, C., Auerbach, J. M., Meiri, N., Bengzon, J., Kennedy, M. B., Segal, M., & McKay, R. D. (1998). Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor. Journal of Neuroscience, 18, 4177-4188.
60. Okiyama, K., Smith, D. H., White, W. F., & McIntosh, T. K. (1998). Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. Brain Research, 792, 291-298.
61. Pang, K. C., & Yoder, R. M. (2001). Neurons in the lateral agranular frontal cortex have divided attention correlates in a simultaneous temporal processing task. Neuroscience, 103, 615-628.
62. Parsons, C., Danysz, W., & Quack, G. (1998). Glutamate in CNS disorders as a target for drug development: An update. Drug News Perspective, 11, 523-569.
63. Patat, A., Molinier, P., Hergueta, T., Brohier, S., Zieleniuk, I., Danjou, P., Warot, D., & Puech, A. (1994). Lack of amnestic, psychotomimetic or impairing effect on psychomotor performance of eliprodil, a new NMDA antagonist. International Clinical Psychopharmacology, 9, 155-162.
64. Pontecorvo, M. J., Clissold, D. B., White, M. F., & Ferkany, J. W. (1991). N-methyl-D-aspartate antagonists and working memory performance: Comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine. Behavioral Neuroscience, 105, 521-535.
65. Priestley, T., & Kemp, J. A. (1994). Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D-aspartic acid receptor complex. Molecular Pharmacology, 46, 1191-1196.
66. Priestley, T., Laughton, P., Macaulay, A. J., Hill, R. G., & Kemp, J. A. (1996). Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324. Neuropharmacology, 35, 1573-1581.
67. Przegalinski, E., Tatarczynska, E., Deren-Wesolek, A., & Chojnacka-Wojcik, E. (1996). Anticonflict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors. Pharmacology, Biochemistry and Behavior, 54, 73-77.
68. Pussinen, R., Nieminen, S., Koivisto, E., Haapalinna, A., Riekkinen, P., Sr., & Sirvio, J. (1997). Enhancement of intermediate-term memory by an alpha-1 agonist or a partial agonist at the glycine site of the NMDA receptor. Neurobiology of Learning and Memory, 67, 69-74.
69. Ritter, L. M., Unis, A. S., & Meador-Woodruff, J. H. (2001) Ontogeny of ionotropic glutamate receptor expression in human fetal brain. Brain, 127, 123-33.
70. Robichon, R., Randall, P. K., & Leslie, S. W (1997). A partial agonist model used in the allosteric modulation of the NMDA receptor. European Journal of Pharmacology, 328, 255-63.
71. Rock, D. M., & Macdonald, R. L. (1992). The polyamine spermine has multiple actions on N-methyl-D-aspartate receptor single-channel currents in cultured cortical neurons. Molecular Pharmacology, 41, 83-88.
72. 3H]norepinephrine release. Journal of Pharmacology and Experimental Therapeutics, 255, 1060-1063.
73. Sanes, J. R., & Lichtman, J. W. (1999). Can molecules explain long-term potentiation? Natural Neuroscience, 2, 597-604.
74. Sanger, D. J. (1992). NMDA antagonists disrupt timing behaviour in rats. Behavioural Pharmacology, 3, 593-600.
75. Sanger, D. J., & Jackson, A. (1989). Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats. Journal of Pharmacology and Experimental Therepeutics, 248, 1215-1221.
76. Sato, K., Morimoto, K., Yamada, N., Kuroda, S., & Hayabara, T. (1995). NBQX, a selective antagonist of the AMPA receptor, affects neither field potentials nor long-term potentiation in vivo. Brain Research, 683, 279-282.
77. Schell, M. J., Brady, R. O., Jr., Molliver, M. E., & Snyder, S. H. (1997). D-serine as a neuromodulator: Regional and developmental localizations in rat brain glia resemble NMDA receptors. Journal of Neuroscience, 17, 1604-1615.
78. Schneider, J. S., Tinker, J. P., Van Velson, M., & Giardiniere, M. (2000). Effects of the partial glycine agonist D-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys. Brain Research, 860, 190-194.
79. Seguin, L., & Millan, M. J. (1994). The glycine B receptor partial agonist, (+)-HA966, enhances induction of antinociception by RP 67580 and CP-99,994. European Journal of Pharmacology, 253, R1-3.
80. Standaert, D. G., Testa, C. M., Rudolf, G. D., & Hollingsworth, Z. R. (1996). Inhibition of N-methyl-D-aspartate glutamate receptor subunit expression by antisense oligonucleotides reveals their role in striatal motor regulation. Journal of Pharmacology and Experimental Therapeutics, 276, 342-352.
81. Steckler, T., Andrews, J. S., Marten, P., Turner, J. D. (1993). Effects of NBM lesions with two neurotoxins on spatial memory and auto-shaping. Pharmacology, Biochemistry and Behavior 44, 877-889.
82. Stephens, D. N., Cole, B. J., Tonkiss, J., Morris, R. G., & Rawlins, J. N. (1996). AMPA antagonists differ from NMDA antagonists in their effects on operant DRL and delayed matching to position tasks. Psychopharmacology, 126, 249-259.
83. Stern, P., Behe, P., Schoepfer, R., & Colquhoun, D. (1992). Single-channel conductances of NMDA receptors expressed from cloned cDNAs: Comparison with native receptors. Proceedings of the Royal Society of London Biological Sciences, 250, 271-277.
84. Sutherland, R. J., Weisend, M. P., Mumby, D., Astur, R. S., Hanlon, F. M., Koerner, A., Thomas, M. J., Wu, Y., Moses, S. N., Cole, C., Hamilton, D. A., and Hoesing, J. M. (2001). Retrograde amnesia after hippocampal damage: Recent vs. remote memories in two tasks. Hippocampus, 11, 27-42.
85. Tallarida, R. J., & Murray, R. B., (1987). Manual of Pharmacologic Calculations with Computer programs. New York: Springer-Verlag.
86. Tang, Y. P., Shimizu, E., Dube, G. R., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999). Genetic enhancement of learning and memory in mice. Nature, 401, 63-69.
87. Temple, M. D., & Hamm, R. J. (1996). Chronic, post-injury administration of D-cycloserine, an NMDA partial agonist, enhances cognitive performance following experimental brain injury. Brain Research, 741, 246-251.
88. Tsai, G. E., Falk, W. E., Gunther, J., & Coyle, J. T. (1999). Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. American Journal of Psychiatry, 156, 467-469.
89. Tsien, J. Z. (2000). Building a brainier mouse. Science, 282, 62-68.
90. Tsien, J. Z. (2000). Linking Hebb's coincidence-detection to memory formation. Current Opinion in Neurobiology, 10, 266-273.
91. Turecek, R., & Trussell, L. O. (2001). Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse. Nature, 411, 587-590.
92. van Haaren, F., van Hest, A., & van Hattum, T. (1989). Scopolamine and methylscopolamine differentially affect fixed-consecutive-number performance of male and female Wistar rats. Pharmacology, Biochemistry, and Behavior, 33, 361-365.
93. Viu, E., Zapata, A., Capdevila, J., Skolnick, P., & Trullas, R. (2000), Glycine (B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning. Neurobiology of Learning and Memory, 74, 146-160.
94. Walker, D. L., Gold, P. E. (1992). Impairment of spontaneous alternation performance by an NMDA antagonist: Attenuation with non-NMDA treatments Behavioral and Neural Biology, 58, 69-71.
95. Ward, L., Mason, S. E., & Abraham, W. C. (1990). Effects of the NMDA antagonists CPP and MK-801 on radial arm maze performance in rats. Pharmacology, Biochemistry, and Behavior, 35, 785-790.
96. Watanabe, M., Inoue, Y., Sakimura, K., & Mishina, M. (1993). Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. Journal of Comparitive Neurology, 338, 377-390.
97. Watson, G. B., & Lanthorn, T. H. (1990). Pharmacological characteristics of cyclic homologues of glycine at the N-methyl-D-aspartate receptor-associated glycine site. Neuropharmacology, 29, 727-730.
98. Wenzel, A., Scheurer, L., Kunzi, R., Fritschy, J. M., Mohler, H., & Benke, D. (1995). Distribution of NMDA receptor subunit proteins NR2A, 2B, 2C and 2D in rat brain. NeuroReport, 7, 45-48.
99. Willmore, C., Bespalov, A. Y., & Beardsley, P. M. (2001). Competitive and noncompetitive NMDA antagonist effects in rats trained to discriminate lever-press counts. Pharmacology, Biochemistry and Behavior, 69, 493-502.
100. Wlaz, P. (1998). Anti-convulsant and adverse effects of the glycineB receptor ligands, D-cycloserine and L-701,324: Comparison with competitive and non-competitive N-methyl-D-aspartate receptor antagonists. Brain Research Bulletin, 46, 535-540.
101. Wong, P. T., Neo, L. H., Teo, W. L., Feng, H., Xue, Y. D., & Loke, W. H. (1997). Deficits in water escape performance and alterations in hippocampal cholinergic mechanisms associated with neonatal monosodium glutamate treatment in mice. Pharmacology, Biochemistry, and Behavior, 57, 383-388.
102. Xu, X., Klinger, P., & Davis, R. (1995). Comparative anterograde amnestic and anticonvulsant effects of two types of NMDA receptor antagonists: MK 801 and HA 966. Psychopharmacology, 117, 333-339.