AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations

Brain Research Bulletin

Volumn 52, Issue 6, 2000, Pages 511-517

  Kapus, Gábor ^a   Székely, József I ^b   Durand, Jacques ^c   Ruiz, Arnaud ^c   Tarnawa, István ^d  

^a EGIS PHARMACEUTICALS LTD   (Hungary)

^b Institute for Drug Research Budapest   (Hungary)

^c U de Neurocybernetique Cell   (France)

^d GEDEON RICHTER LTD   (Hungary)

Author keywords

AMPA receptors; GYKI 52466; Hippocampus; Long term potentiation; NBQX

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR;

ANIMAL CELL; ARTICLE; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MEMORY; NEURODEGENERATIVE DISEASES; NEURONS; ORGAN CULTURE TECHNIQUES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA;

EID: 0343390430     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(00)00288-4     Document Type: Article

References (41)

1. Aniksztejn, L.; Ben-Ari, Y. Expression of LTP by AMPA and/or NMDA receptors is determined by the extent of NMDA receptors activation during the tetanus. J. Neurophysiol. 74:2349-2357; 1995.
2. Asztely, F.; Wigström, H.; Gustafsson, B. The relative contribution of NMDA receptor channels in the expression of long-term potentiation in the hippocampal CA1 region. Eur. J. Neurosci. 4:681-690; 1992.
3. Bashir, Z. I.; Alford, S.; Davies, S. N.; Randall, A. D.; Collingridge, G. L. Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature 349:156-158; 1991.
4. Bashir, Z. I.; Bortolotto, Z. A.; Davies, C. H. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature 363:347-350; 1993.
5. Benke, T. A.; Lühti, A.; Isaac, J. T. R.; Collingridge, G. L. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature 393:793-797; 1998.
6. Beretta, N.; Berton, F.; Bianchi, R.; Brunelli, M.; Capogna, M.; Francesconi, W. Long-term potentiation of NMDA receptor-mediated EPSP in guinea-pig hippocampal slices. Fur. J. Neurosci. 3:850-854; 1991.
7. Bleakman, D.; Lodge, D. Neuropharmacology of AMPA and kainate receptors. Neuropharmacology 37:1187-1204; 1998.
8. Bliss, T. V. P.; Collingridge, G. L. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361:31-39; 1993.
9. Clark, A. K.; Collingridge, G. L. Synaptic potentiation of dual-component excitatory postsynaptic currents in the rat hippocampus. J. Physiol. 482:39-52; 1995.
10. Collingridge, G. L.; Herron, C. F.; Lester, R. A. J. Synaptic activation of N-methyl-D-aspartate receptors in the Schaffer collateral-commissural pathway of rat hippocampus. J. Physiol. 399:283-300; 1988.
11. Danysz, W.; Zajaczkowski, W.; Parsons, C. G. Modulation of learning processes by ionotropic glutamate receptor ligands. Behav. Pharmacol. 6:455-474; 1995.
12. A receptors to the induction of NMDAR-dependent LTP in CA1. Neurosci Lett. 238:119-122; 1997.
13. Dóczi, J.; Banczerowski-Pelyhe, I.; Barna, B.; Világi, I. Effect of a glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices. Brain Res. Bull. 49:435-440; 1999.
14. Donevan, S. D.; Rogawski, M. A. GYKI 52466, a 2,3-benzodiazepine, is highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron 10:51-59; 1993.
15. Dürmüller, N.; Craggs, M. D.; Meldrum, B. S. The effect of the non-NMDA receptor antagonists GYKI 52466 and NBQX and the competitive NMDA receptor antagonist d-CPPene on the development of amygdala kindling and on amygdala-kindled seizures. Epilepsy Res. 17:164-174; 1994.
16. Farkas, S.; Tarnawa, I.; Berzsenyi, P.; Pátfalusi, M.; Andrási, F.; Ono, H. The role of non-NMDA excitatory amino acid receptors in the mediation of spinal reflexes. In: Takai, K., ed. Frontiers and new horizons in aminoacid research. Amsterdam: Elsevier; 92:471-475.
17. Grover, L. M.; Teyler, T. J. Two components of LTP induced by different patterns of afferent activation. Nature 247:477-479; 1990.
18. Gyertyan, L; Gigler, G.; Simo, A. The neuroprotective and hypotermic effect of GYKI 52466, a non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazopropionic acid antagonist on histological and behavioural variables in the gerbil global ischemia model. Brain Res. Bull. 50:179-186; 1999.
19. Herron, C. E.; Lester, R. A. J.; Coan, E. J.; Collingridge, G. L. Frequency-dependent involvement of NMDA receptors in the hippocampus: A novel synaptic mechanism. Nature 322:265-268; 1986.
20. Jensen, J. B.; Schousboe, A.; Pickering, D. S. AMPA receptor mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization. Neurochem. Int. 32:505-513; 1998.
21. Kauer, J. A.; Malenka, R. C.; Nicoll, R. A. A persistent postsynaptic modification mediates long-term potentiation in the hippocampus. Neuron 1:911-917; 1988.
22. Kullmann, D. M. Amplitude fluctuations of dual-component EPSCs in hippocampal pyramidal cells: Implications for long-term potentiation. Neuron 12:1111-1120; 1994.
23. Leung, L. S.; Au, A. S. Long-term potentiation as a function of test pulse intensity: A study using input/output profiles. Brain Res. Bull. 33:353-360; 1994.
24. Lynch, G. Memory and the brain: Unexpected chemistries and a new pharmacology. Neurobiol. Learn. Mem. 70:82-100; 1998.
25. 2+ of the induction and expression of LTP. Science 242:1694-1697; 1984.
26. Muller, D.; Lynch, G. Long-term potentiation differentially affects two components of synaptic responses in hippocampus. Proc. Natl. Acad. Sci. USA 85:9346-9350; 1988.
27. Muller, D.; Joly, M.; Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242:1694-1697; 1988.
28. Osipenko, O.; Mike, A.; Gyevai, A.; Vizi, E. S. Evidence that GYKI 52466, a novel non-NMDA antagonist enhances the decay of kainate-induced current in cultured chicken cortical neurons. Dev. Brain Res. 77:257-263; 1994.
29. Parsons, C. G.; Danysz, W.; Quack, G. Glutamate in CNS disorders as a target for drug development: An update. Drug News Perspect. 11:523-569; 1998.
30. 2+-permeable AMPA receptors in neurological disorders. Trends Neurosci. 20:464-470; 1997.
31. Perkel, D. J.; Nicoll, R. A. Evidence for all-or-none regulation of neurotransmitter release: Implications for long-term potentiation. J. Physiol. 471:481-500; 1993.
32. Raymond, L. Y.; Blackstone, C. D.; Huganir, R. L. Phosphorylation of amino acid neurotransmitter receptors in synaptic plasticity. Trends Neurosci. 16:147-153; 1993.
33. Rammes, G.; Parsons, C.; Müller, W.; Swandulla, D. Modulation of fast excitatory synaptic transmission by cyclothiazide and GYKI 52466 in the rat hippocampus. Neurosci. Lett. 175:21-24; 1994.
34. Rogawski, M. A. Therapeutic potential of excitatory amino acid an-tagonists: Channel blockers and 2,3-benzodiazepines. Trends Pharmacol. Sci. 14:325-331; 1993.
35. Sato, K.; Morimoto, K.; Yamada, N.; Kuroda, S.; Hayabara, T. NBQX, a selective antagonist of the AMPA receptor, affects neither field potentials nor long-term potentiation in vivo. Brain Res. 683:279-282; 1995.
36. Tarnawa, I.; Molnár, P.; Gaál, L.; Andrási, F. Inhibition of hippocampal field porentials by GYKI 52466 in vitro and in vivo. Acta Physiol. Hung. 79:163-169; 1992.
37. Tarnawa, I.; Vizi, E. S. 2,3-Benzodiazepine AMPA antagonists. Restorative Neurol. Neurosci. 12:1-17; 1998.
38. Xie, X.; Berger, T. W.; Barrionuevo, G. Isolated NMDA receptor-mediated synaptic responses express both LTP and LTD. J. Neurophysiol. 67:1009-1013; 1992.
39. Vizi, E. S.; Mike, A.; Tarnawa, I. 2,3-Benzodiazepines (GYKI 52466 and analogs): Negative allosteric modulators of AMPA receptors. CNS Drug Rev. 2:91-126; 1996.
40. Vizi, E. S.; Mike, A.; Tarnawa, I. The functional study of kainate receptors: Hopes and doubts. Trends Neurosci. 20:396; 1997.
41. Zorumski, C. H.; Yamada, K. A.; Price, M. T.; Olney, J. W. A benzodiazepine recognition site associated with the non-NMDA glutamate receptor. Neuron 10:61-67; 1993.