The role of CREB and other transcription factors in the pharmacotherapy and etiology of depression

Annals of Medicine

Volumn 34, Issue 5, 2002, Pages 348-356

  Sulser, Fridolin ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antidepressants; CREB; Differential display; Gene expression; Glucocorticoid receptor (GR); Major depression; Transcription factors

Indexed keywords

ANTIDEPRESSANT AGENT; CALCITRIOL RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN FOS; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DEPRESSION; DIFFERENTIAL DISPLAY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; GENE STRUCTURE; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SUICIDE;

ANIMALS; ANTIDEPRESSIVE AGENTS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSION; GENE EXPRESSION REGULATION; HUMANS; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION FACTORS;

EID: 0036432834     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.1080/078538902320772106     Document Type: Article

References (77)

1. Rossby SP, Sulser F. Antidepressants: Beyond the synapse. In: Skolnick Ph, ed. Antidepressants, New Pharmacological Strategies. Totowa, NJ: Humana Press; 1997; 195-212.
2. Faisst S, Meyers S. Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res 1992; 20: 3-26.
3. Hunter T, Karin M. The regulation of transcription by phosphorylation. Cell 1992; 70: 375-87.
4. Jans DA. The regulation of protein transport to the nucleus by phosphorylation. Biochem J 1995; 311: 705-16.
5. Vandromme M, Gauthier-Rouviere C, Lamb N, Fernandez A. Regulation of transcription factor localization: Fine-tuning of gene expression. Trends Bioch Sci 1996; 21: 59-64.
6. Vetulani J, Sulser F. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature 1975; 257: 495-6.
7. Vetulani J, Stawarz RJ, Sulser F. Adaptive mechanisms of the noradrenergic cyclic AMP generating system in the limbic forebrain of the rat: Adaptation to persistent changes in the availability of norepinephrine (NE). J Neurochem 1976; 27: 661-6.
8. Greengard P. The neurobiology of slow synaptic transmission. Science 2001; 294: 1024-30.
9. Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci USA 1986; 83: 2797-801.
10. Hausdorf WP, Caron MG, Lefkowitz RJ. Turning off the signal-desensitization of β-adrenergic receptor function. FASEB J 1993; 4: 2881-8.
11. Premont RT, Inglese J, Lefkowitz RJ. Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J 1995; 9: 175-82.
12. Nibuya M, Nestler EJ, Duman RS. Chronic antidepressant administration increases the expression of CREB in rat hippocampus. J Neurosci 1996; 16: 2365-72.
13. Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, et al. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol 1993; 13: 4852-9.
14. Nestler EJ, Terwilliger RZ, Duman RS. Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J Neurochem 1989; 53: 1644-7.
15. Silva AJ, Kogan JH, Frankland PW, Kida S. CREB and Memory. Annu Rev Neurosci 1998; 21: 127-48.
16. Meyer TE, Habener JF. Cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) and related transcriptional-activating deoxyribonucleic acid-binding proteins. Endocr Revs 1993; 14: 269-90.
17. Hunter T. Protein Kinases and phosphatases: The yin and yang of protein phosphorylation and signaling. Cell 1995; 80: 225-36.
18. Wadzinski BE, Wheat WH, Jaspers S, Peruski LF Jr, Lickteig RL, Johnson GL, et al. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol Cell Biol 1993; 13: 2822-34.
19. Yamamoto KK, Gonzalez GA, Menzel P, Rivier J, Montminy MR. Characterisation of a bipartite activator domain in transcription factor CREB. Cell 1990; 60: 611-7.
20. Manier DH, Shelton RC, Sulser F. Cross-talk between PKA and PKC in human fibroblasts: What are the pharmacotherapeutic implications? J Affect Disord 2001; 65: 275-9.
21. Rossby SP, Manier DH, Liang S, Nalepa I, Sulser F. Venlafaxine: Pharmacological actions beyond aminergic receptors. Int J Neuropsychopharmacol 1999; 2: 1-8.
22. Manier DH, Shelton RC, Sulser F. Noradrenergic antidepressants: Does chronic treatment increase or decrease nuclear CREB-P? J Neural Transm 2002; 109: 91-9.
23. Heydorn WE, Brunswick FT, Frazer A. Effect of treatment of rats with antidepressants on melatonin concentrations in the pineal gland and serum. J Pharmacol Exp Ther 1982; 222: 534-43.
24. Friedman E, Yocca FD, Cooper TD. Antidepressant drugs with varying pharmacological profiles alter rat pineal beta adrenergic mediated function. J Pharmacol Exper Therap 1984; 228: 545-50.
25. Schwaninger M, Schöfl C, Blume R, Rössig L, Knepel W. Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription. Molec Pharmacol 1995; 47:1112-8.
26. Thome J, Sakai N, Shin K, Steffen C, Zhang YJ, Impey S et al. cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 2000; 20: 4030-6.
27. Nestler EJ, McMahon A, Sabban EL, Tallman JF, Duman RS. Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in rat locus coeruleus. Proc Natl Acad Sci USA 1990; 87: 7522-6.
28. Brady LS, Whitfield HJ Jr, Fox RJ, Gold PW, Herkenham M. Long-term antidepressant administration alters corticotropin releasing hormone, tyrosine hydroxylase and mineralocorticoid receptor gene expression in rat brain. J Clin Invest 1991; 87: 831-7.
29. Hosoda K, Duman RS. Regulation of B1-adrenergic receptor mRNA and ligand binding by antidepressant treatments and norepinephrine depletion in rat frontal cortex. J Neurochem 1993; 69: 1335-43.
30. Wong M, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P et al. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci USA 2000; 97: 325-30.
31. Montgomery SA. Which antidepressant for which depression? In: Briley M, Montgomery SA, eds. Antidepressant Therapy at the Dawn of the Third Millenium: London: Martin Dunitz; 1998: 333-48.
32. Kitayama I, Janson AM, Cintra A, Fuxe K, Agnati LF, Øgren SO, et al. Effects of chronic imipramine treatment on glucocorticoid receptor immunoreactivity in various regions of the rat brain. J Neural Transm 1988; 73: 191-203.
33. Budziszewska B, Siwanowicz J, Przegaliñski E. The effect of chronic treatment with antidepressant drugs on the corticosteroid receptor levels in the rat hippocampus. Pol J Pharmacol 1994; 46: 147-52.
34. Peiffer A, Veilleaux S, Barden N. Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain. Psychoneuroendocrinology 1991; 16: 505-15.
35. Seckl JR, Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology 1992; 55: 621-6.
36. Rossby SP, Nalepa I, Huang M, Perrin C, Burt A, Schmidt D et al. Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant. Brain Res 1995; 687: 79-82.
37. Weigel NL. Steroid hormone receptors and their regulation by phosphorylation. Biochem J 1996; 319: 657-67.
38. O'Malley BW, Onate S, Smith C, Tsai S, Tsai MJ. Molecular mechanisms of steroid receptor action. In: Fortner JG, Sharp PhA, eds. Accomplishment in Cancer Research: 1996. Philadelphia: Lippincott-Raven; 1997: 157-67.
39. O'Malley BW, Tsai MJ. Mechanisms of regulation of gene transcription by steroid receptors. In: Cohen P, Foulkes JG, eds. The Hormonal Control of Gene Transcription; Amsterdam: Elsevier; 1991: 101-16.
40. Beato M. Transcriptional control by nuclear receptors. FASEB J 1991; 5: 2044-51.
41. Eiring A, Sulser F. An increased synaptic availability of norepinephrine is not essential for antidepressant induced increases in hippocampal GR mRNA. J Neural Transm 1997; 104: 1255-8.
42. Honegger U, Disler B, Wiesmann UN. Chronic exposure of human cells in culture to the tricyclic antidepressant desipramine reduces the number of beta adrenoceptors. Biochem Pharmacol 1986; 35: 1899-902.
43. Pepin MC, Govindan MV, Barden N. Increased glucocorticoid receptor gene promoter activity after antidepressant treatment. Mol Pharmacol 1992; 41: 1016-22.
44. Pariante CM, Pearce BD, Pisell TL, Owens MJ, Miller AH. Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol Pharmacol 1997; 52: 571-81.
45. Brown JR, Ye Hong, Bronson T, Dikkes P, Greenberg M. A defect in nurturing in mice lacking the immediate early gene fosB. Cell 1996; 86: 297-309.
46. Göttlicher M, Heck S, Herrlich P. Transcriptional cross-talk, the second mode of steroid hormone receptor action. J Mol Med 1998; 76: 480-9.
47. Manier DH, Shelton RC, Ellis T, Peterson ChS, Eiring A, Sulser F. Human fibroblasts as a relevant model of signal transduction in affective disorders. J Affect Disord 2000; 61: 51-8.
48. Shelton R, Manier DH, Sulser F. Cyclic cAMP-dependent protein kinase activity in major depression. Am J Psychiatry 1996; 153: 1037-42.
49. Shelton RC, Manier DH, Ellis T, Peterson ChS, Sulser, F. Cyclic AMP dependent protein kinase in subtypes of major depression and normal volunteers. Int J Neuropsychopharmacol 1999; 3: 187-92.
50. 3H] cyclic AMP binding in postmortem brain from subjects with bipolar affective disorder. J Neurochem 1997; 68: 297-304.
51. Dwivedi Y, Roberts R, Conley RC, Tamminga C, Pandey GN. Protein kinase A in the postmortem brain of suicide victims. Biol Psychiatry 2000; 47: 248.
52. Stone EA. Subsensitivity to noreprinephrine as a link between adaptation to stress and antidepressant therapy: A hypothesis. Res Commun Psychol Psychiat Behav 1979; 4: 241-55.
53. Stone EA, Platt JE. Brain adrenergic receptors and resistance to stress. Brain Res 1982; 237: 405-14.
54. Holsboer F, Barden N. Antidepressants and hypothalamicpituitary-adrenocortical regulation. Endocr Rev 1996; 17: 187-205.
55. Barden N, Ruel J, Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 1995; 18: 6-11.
56. Holsboer F, Barden N. Antidepressants and HPA regulation. Endocr Rev 1996; 17: 187-203.
57. Nordeen SK, Moyer ML, Bona BJ. The coupling of multiple signal transduction pathways with steroid response mechanisms. Endocrinology 1994; 134: 1723-32.
58. Duman RS, Vajdya V, Nibuya M, Morinobu S, Fitzgerald L. Stress, antidepressant treatments, and neurotrophic factors: Molecular and cellular mechanisms. Neuroscientist 1995; 1: 351-60.
59. Duman RS, Nakagawa S, Malberg J. Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology 2001; 25: 836-44.
60. Sheline YI, Wang PW, Gado MH, Hsernansky JG, Vannier MW. Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 1996; 93: 3908-13.
61. Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS. Hippocampal volume reduction in major depression. Am J Psychiatry 2000; 157: 115-7.
62. Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, Pittman SD, Meltzer HY, et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry 1999; 45: 1085-98.
63. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging. A meta analytic study. Arch Gen Psychiatry 1998; 55: 433-40.
64. Müller MB, Lucassen PJ, Yassouridis A, Hoogendijk WJG, Holsboer F, Swaab DE. The human hippocampus in major depression or following administration of glucocorticoids: No evidence for major structural alterations. Soc Neurosci 1998; 24: 990.
65. Liang P, Pardee AB. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992; 257: 967-71.
66. Watson SJ, Akil H. Gene chips and arrays revealed: A primer on their power and their uses. Biol Psychiatry 1999; 45: 533-43.
67. Chen G, Zeng WZ, Yuan PX, Huang LD, Jiang YM, Zhao ZH et al. The mood stabilizing agents lithium and valproate robustly increase the expression of the neuroprotective protein bc1-2 in the CNS. J Neurochem 1999; 72: 879-82.
68. Chen G, Huang Li, Zeng W, Manji H. Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: Long-term effects on cell survival and transcript stability. Int J Neuropsychopharmacol 2001; 4: 47-64.
69. Wang J, Brown C, Chen B, Young LT. Identification of mood stabilizer-regulated genes by differential-display PCR. Int J Neuropsychopharmacol 2001; 4: 65-74.
70. Wang JF, Brown C, Young LT. Differential display PCR reveals novel targets for the mood stabilizing drug valproate including the molecular chaperone GRP78. Mol Pharmacol 1999; 55: 521-7.
71. Breviario F, d'Aniello EM, Golay J, Peri G, Bottazzi B, Bairoch A et al. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem 1992; 267: 22190-7.
72. Goodman AR, Cardozo T, Abagyan R, Altmeyer A, Wisniewski HG, Vilcek J. Long pentraxins: An emerging group of proteins with diverse functions. Cytokine Growth Factor Rev 1996; 7: 191-202.
73. Levine MA, Barak Y, Chengappa KNR, Rapoport A, Rebey M, Barak V. Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology 1999; 40: 171-6.
74. Elkes J. A view through the rear view mirror: Personal beginnings. In anniversary anthology. American College of Neuropsychopharmacology 1986; 181-94.
75. Sternberg EM. The Balance Within. New York: WH Freeman; 2000.
76. Lamas M, Sassone-Corsi P. Coupling transcription to signal transduction: CREM and cAMP. In: Papavassilion AG, ed. Transcription Factors in Eukaryotes. Austin, Texas: Landes Bioscience; 1997: 51-65.
77. Rossby SP, Liang S, Manier DH, Chakrabarti A, Shelton RC, Sulser F. Molecular psychopharmacology as a prelude to a molecular psychopathology of affective disorders; The significance of differential display methodology to study programs of gene expression. In: Briley M, Sulser F, eds. Molecular Genetics of Mental Disorders. London: Martin Dunitz; 2000: 31-46.