Human cytomegalovirus induces a direct inhibitory effect on antigen presentation by monocyte-derived immature dendritic cells

British Journal of Haematology

Volumn 119, Issue 1, 2002, Pages 189-198

  Grigoleit, Ulrich ^a   Riegler, Susanne ^a   Einsele, Hermann ^a,b   Sampaio, Kerstin Laib ^a   Jahn, Gerhard ^a   Hebart, Holger ^a   Brossart, Peter ^a   Frank, Friderike ^a   Sinzger, Christian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Antigen presentation; Co stimulatory molecules; Dendritic cells; HCMV; Immune paralysis

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA; VIRUS ANTIGEN;

ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; LEUKOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; PRIORITY JOURNAL;

ANTIGEN PRESENTATION; ANTIGENS, CD; CYTOMEGALOVIRUS INFECTIONS; DENDRITIC CELLS; DOWN-REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; MONOCYTES; PHENOTYPE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036398430     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03798.x     Document Type: Article

References (31)

1. Brossart, P. & Bevan, M.J. (1997) Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: Pathway of presentation and regulation by cytokines. Blood, 90, 1594-1599.
2. Einsele, H., Ehninger, G., Steidle, M., Fischer, I., Bihler, S., Gerneth, F., Vallbracht, A., Schmidt, H., Waller, H.D. & Muller, C.A. (1993) Lymphocytopenia as an unfavorable prognostic factor in patients with cytomegalovirus infection after bone marrow transplantation. Blood, 82, 1672-1678.
3. Gnann, Jr, J.W., Ahlmen, J., Svalander, C., Olding, L., Oldstone, M.B. & Nelson, J.A. (1988) Inflammatory cells in transplanted kidneys are infected by human cytomegalovirus. American Journal of Pathology, 132, 239-248.
4. Hamprecht, K. & Steinmassl, M. (1994) Low-dose human cytomegalovirus infection of human fibroblast cultures induces lymphokine-activated killer cell resistance: interferon-beta-mediated target cell protection does not correlate with upregulation of HLA class I surface molecules. Immunology, 82, 171-177.
5. Heise, M.T., Pollock, J.L., O'Guin, A., Barkon, M.L., Bormley, S. & Virgin, H.W.T. (1998) Murine cytomegalovirus infection inhibits IFN gamma-induced MHC class II expression on macrophages: the role of type I interferon. Virology, 241, 331-344.
6. Hengel, H., Esslinger, C., Pool, J., Goulmy, E. & Koszinowski, U.H. (1995) Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells. Journal of General Virology, 76, 2987-2997.
7. Hengel, H., Reusch, U., Geginat, G., Holtappels, R., Ruppert, T., Hellebrand, E. & Koszinowski, U.H. (2000) Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus. Journal of Virology, 74, 7861-7868.
8. Humar, A., Wood, S., Lipton, J., Messner, H., Meharchand, J., McGeer, A., MacDonald, K. & Mazzulli, T. (1998) Effect of cytomegalovirus infection on 1-year mortality rates among recipients of allogeneic bone marrow transplants. Clinical Infectious Disease, 26, 606-610.
9. Ibanez, C.E., Schrier, R., Ghazal, P., Wiley, C. & Nelson, J.A. (1991) Human cytomegalovirus productively infects primary differentiated macrophages. Journal of Virology, 65, 6581-6588.
10. Jahn, G., Stenglein, S., Riegler, S., Einsele, H. & Sinzger, C. (1999) Human cytomegalovirus infection of immature dendritic cells and macrophages. Intervirology, 42, 365-372.
11. Jones, T.R., Wiertz, E.J., Sun, L., Fish, K.N., Nelson, J.A. & Ploegh, H.L. (1996) Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proceedings of the National Academy of Sciences of the United States of America, 93, 11327-11333.
12. Knight, D.A., Waldman, W.J. & Sedmak, D.D. (1997) Human cytomegalovirus does not induce human leukocyte antigen class II expression on arterial endothelial cells. Transplantation, 63, 1366-1369.
13. Lathey, J.L. & Spector, S.A. (1991) Unrestricted replication of human cytomegalovirus in hydrocortisone-treated macrophages. Journal of Virology, 65, 6371-6375.
14. Lehner, P.J., Karttunen, J.T., Wilkinson, G.W. & Cresswell, P. (1997) The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation. Proceedings of the National Academy of Sciences of the United States of America, 94, 6904-6909.
15. Ljungman, P. (1998) Immune reconstitution and viral infections after stem cell transplantation. Bone Marrow Transplantation, 21, 72-74s.
16. Mendelson, M., Monard, S., Sissons, P. & Sinclair, J. (1996) Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors. Journal of General Virology, 77, 3099-3102.
17. Miller, D.M., Rahill, B.M., Boss, J.M., Lairmore, M.D., Durbin, J.E., Waldman, J.W. & Sedmak, D.D. (1998) Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. Journal of Experimental Medicine, 187, 675-683.
18. Minton, E.J., Tysoe, C., Sinclair, J.H. & Sissons, J.G. (1994) Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow. Journal of Virology, 68, 4017-4021.
19. Odeberg, J. & Söderberg-Naucler, C. (2001) Reduced expression of HLA class II molecules and interleukin-10 and transforming growth factor β1-independent suppression of T-cell proliferation in human cytomegalovirus-infected macrophage cultures. Journal of Virology, 75, 5174-5181.
20. Onno, M., Pangault, C., Le Friec, G., Guilloux, V., Andre, P. & Fauchet, R. (2000) Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection. Journal of Immunology, 164, 6426-6434.
21. Redpath, S., Angulo, A., Gascoigne, N.R. & Ghazal, P. (1999) Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10. Journal of Immunology, 162, 6701-6707.
22. Riegler, S., Hebart, H., Einsele, H., Brossart, P., Jahn, G. & Sinzger, C. (2000) Monocyte-derived dendritic cells are permissive to the complete replicative cycle of human cytomegalovirus. Journal of General Virology, 81 Part 2, 393-399.
23. Sallusto, F. & Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. Journal of Experimental Medicine, 179, 1109-1118.
24. Sinclair, J. & Sissons, P. (1996) Latent and persistent infections of monocytes and macrophages. Intervirology, 39, 293-301.
25. Sinzger, C., Muntefering, H., Loning, T., Stoss, H., Plachter, B. & Jahn, G. (1993) Cell types infected in human cytomegalovirus placentitis identified by immunohistochemical double staining. Virchows Archives A: Pathology Anatomy and Histopathology, 423, 249-256.
26. Sinzger, C., Plachter, B., Grefte, A., The, T.H. & Jahn, G. (1996) Tissue macrophages are infected by human cytomegalovirus in vivo. Journal of Infectious Disease, 173, 240-245.
27. Sinzger, C., Schmidt, K., Knapp, J., Kahl, M., Beck, R., Waldman, J., Hebart, H., Einsele, H. & Jahn, G. (1999) Modification of human cytomegalovirus tropism through propagation in vitro is associated with changes in the viral genome. Journal of General Virology, 80, 2867-2877.
28. Söderberg-Naucler, C., Fish, K.N. & Nelson, J.A. (1997) Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell, 91, 119-126.
29. Taylor Wiedeman, J., Sissons, J.G., Borysiewicz, L.K. & Sinclair, J.H. (1991) Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. Journal of General Virology, 72, 2059-2064.
30. Tomazin, R., Boname, J., Hegde, N.R., Lewinsohn, D.M., Altschuler, Y., Jones, T.R., Cresswell, P., Nelson, J.A., Riddell, S.R. & Johnson, D.C. (1999) Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Natural Medicine, 5, 1039-1043.
31. Wiertz, E.J., Jones, T.R., Sun, L., Bogyo, M., Geuze, H.J. & Ploegh, H.L. (1996) The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell, 84, 769-779.