Reduced expression of HLA class II molecules and interleukin-10- and transforming growth factor β1-independent suppression of T-cell proliferation in human cytomegalovirus-infected macrophage cultures

Journal of Virology

Volumn 75, Issue 11, 2001, Pages 5174-5181

  Odeberg, Jenny ^a   Söderberg Nauclér, Cecilia ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA1;

ANTIGEN EXPRESSION; ARTICLE; CYTOKINE PRODUCTION; CYTOMEGALIC INCLUSION BODY DISEASE; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REPLICATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CELLS, CULTURED; CYTOMEGALOVIRUS; DOWN-REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DP ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MACROPHAGES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0343898206     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.11.5174-5181.2001     Document Type: Article

References (36)

1. Ahlfors, K. 1984. IgG antibodies to cytomegalovirus in a normal urban Swedish population. Scand. J. Infect. Dis. 16:335-337.
2. Ahn, K., A. Gruhler, B. Galocha, T. R. Jones, E. J. Wiertz, H. L. Ploegh, P. A. Peterson, Y. Yang, and K. Fruh. 1997. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity 6:613-621.
3. Boss, J. M. 1997. Regulation of transcription of MHC class II genes. Curr. Opin. Immunol. 9:107-113.
4. Cerboni, C., M. Mousavi-Jazi, A. Linde, K. Söderström, M. Brytting, B. Wahren, K. Kärre, and E. Carbone. 2000. Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts. J. Immunol. 164:4775-4782.
5. + T-cell clones specifically activated by IE1 peptides in vitro. J. Virol. 70:2162-2169.
6. Fish, K. N., W. Britt, and J. A. Nelson. 1996. A novel mechanism for persistence of human cytomegalovirus in macrophages. J. Virol. 70:1855-1862.
7. Fletcher, J. M., H. G. Prentice, and J. E. Grundy. 1998. Natural killer cell lysis of cytomegalovirus (CMV)-infected cells correlates with virally induced changes in cell surface lymphocyte function-associated antigen-3 (LFA-3) expression and not with the CMV-induced down-regulation of cell surface class I HLA. J. Immunol. 161:2365-2374.
8. Forbes, B. A. 1989. Acquisition of cytomegalovirus infection: an update. Clin. Microbiol. Rev. 2:204-216.
9. Gilbert, J. M., S. R. Riddell, B. Plachter, and P. D. Greenberg. 1996. Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product. Nature 383:720-722.
10. Hengel, H., W. Brune, and U. H. Koszinowski. 1998. Immune evasion by cytomegalovirus - survival strategies of a highly adapted opportunist. Trends Microbiol. 6:190-197.
11. Hengel, H., T. Flohr, G. J. Hammerling, U. H. Koszinowski, and F. Momburg. 1996. Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly. J. Gen. Virol. 77:2287-2296.
12. Jones, T. R., L. K. Hanson, L. Sun, J. S. Slater, R. M. Stenberg, and A. E. Campbell. 1995. Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. J. Virol. 69:4830-4841.
13. Jones, T. R., and L. Sun. 1997. Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains. J. Virol. 71:2970-2979.
14. Jones, T. R., E. J. Wiertz, L. Sun, K. N. Fish, J. A. Nelson, and H. L. Ploegh. 1996. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc. Natl. Acad. Sci. USA 93:11327-11333.
15. + T lymphocytes. J. Virol. 64:5457-5464.
16. Knight, D. A., W. J. Waldman, and D. D. Sedmak. 1997. Human cytomegalovirus does not induce human leukocyte antigen class II expression on arterial endothelial cells. Transplantation 63:1366-1369.
17. + T-cell response is mediated by repression of gamma interferon-induced class II transactivator expression. J. Virol. 73:6582-6589.
18. Lučin, P., I. Pavić, B. Polić, S. Jonjić, and U. H. Koszinowski. 1992. Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J. Virol. 66:1977-1984.
19. Miller, D. M., B. M. Rahill, J. M. Boss, M. D. Lairmore, J. E. Durbin, J. W. Waldman, and D. D. Sedmak. 1998. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J. Exp. Med. 187:675-683.
20. Miller, D. M., Y. Zhang, B. M. Rahill, W. J. Waldman, and D. D. Sedmak. 1999. Human cytomegalovirus inhibits IFN-a stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-a signal transduction. J. Immunol. 162:6107-6113.
21. Ng-Bautista, C. L., and D. D. Sedmak. 1995. Cytomegalovirus infection is associated with absence of alveolar epithelial cell HLA class II antigen expression. J. Infect. Dis. 171:39-44.
22. Redpath, S., A. Angulo, N. R. Gascoigne, and P. Ghazal. 1999. Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10. J. Immunol. 162:6701-6707.
23. Reusser, P. 1991. Cytomegalovirus infection and disease after bone marrow transplantation: epidemiology, prevention, and treatment. Bone Marrow Transplant. 3:52-56.
24. Reyburn, H. T., O. Mandelboim, M. Vales-Gomez, D. M. Davis, L. Pazmany, and J. L. Strominger. 1997. The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. Nature 386:514-517.
25. Riddell, S. R., P. Reusser, and P. D. Greenberg. 1991. Cytotoxic T cells specific for cytomegalovirus: a potential therapy for immunocompromised patients. Rev. Infect. Dis. 13:966-973.
26. Riddell, S. R., B. A. Walter, M. J. Gilbert, and P. D. Greenberg. 1994. Selective reconstitution of CD8+ cytotoxic T lymphocyte responses in immunodeficient bone marrow transplant recipients by the adoptive transfer of T cell clones. Bone Marrow Transplant. 14:78-84.
27. Rinaldo, C. R., Jr. 1994. Modulation of major histocompatibility complex antigen expression by viral infection. Am. J. Pathol. 144:637-650.
28. Sedmak, D. D., A. M. Guglielmo, D. A. Knight, D. J. Birmingham, E. H. Huang, and W. J. Waldman. 1994. Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells. Am. J. Pathol. 144:683-692.
29. Sedmak, D. D., W. H. Roberts, R. E. Stephens, W. J. Buesching, L. A. Morgan, D. H. Davis, and W. J. Waldman. 1990. Inability of cytomegalovirus infection of cultured endothelial cells to induce HLA class II antigen expression. Transplantation 49:458-462.
30. Söderberg, C., S. Larsson, S. Bergstedt-Lindqvist, and E. Möller. 1993. Definition of a subset of human peripheral blood mononuclear cells that are permissive to human cytomegalovirus infection. J. Virol. 67:3166-3175.
31. Söderberg-Naucler, C., K. N. Fish, and J. A. Nelson. 1997. Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91:119-126.
32. Tomasec, P., V. M. Braud, C. Rickards, M. B. Powell, P. McSharry, S. Gadola, V. Cerundolo, L. K. Borysiewicz, A. McMichael, and G. W. G. Wilkinson. 2000. Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 287:1031-1033.
33. + T cells. Nat. Med. 5:1039-1043.
34. Warren, A. P., D. H. Ducroq, P. J. Lehner, and L. K. Borysiewicz. 1994. Human cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes. J. Virol. 68:2822-2829.
35. Wentworth, B. B., and L. French. 1970. Plaque assay of cytomegalovirus strains of human origin. Proc. Soc. Exp. Biol. Med. 135:253-258.
36. Wiertz, E. J., T. R. Jones, L. Sun, M. Bogyo, H. J. Geuze, and H. L. Ploegh. 1996. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84:769-779.