The innate immune response and type 2 diabetes: Evidence that leptin is associated with a stress-related (acute-phase) reaction

Clinical Endocrinology

Volumn 52, Issue 1, 2000, Pages 107-112

  Pickup, John C ^a   Chusney, Gary D ^a   Mattock, Martin B ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADULT; AGED; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; IMMUNE RESPONSE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS;

ACUTE-PHASE REACTION; ADULT; BIOLOGICAL MARKERS; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; LEPTIN; MALE; MIDDLE AGED; N-ACETYLNEURAMINIC ACID;

EID: 0033965630     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2000.00921.x     Document Type: Article

References (31)

1. Ahima, R.S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E. & Flier, J.S. (1996) Role of leptin in the neuroendocrine response to fasting. Nature, 382, 250-252.
2. Bornstein, S.R. (1997) Is leptin a stress related peptide? Nature Medicine, 3, 937.
3. Bornstein, S.R., Uhlmann, K., Haidan, A., Ehrhart-Bornstein, M. & Scherbaum, W.A. (1997) Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Leptin inhibits cortisol release directly. Diabetes, 46, 1235-1238.
4. Caro, J.F., Sinha, M.K., Kolaczynski, J.W., Zhang, P.L. & Considine, R.V. (1996) Leptin: the tale of an obesity gene. Diabetes, 45, 1455-1462.
5. Considine, R.V., Sinha, M.K., Helman, M.L., Kriauciunas, A.K., Stephens, T.W., Nyce, M.R., Ohannesian, J.P., Marco, C.C., McKee, L.J., Bauer, T.L. & Caro, J.F. (1996) Serum immunoreactive leptin concentrations in normal-weight and obese humans. New England Journal of Medicine, 334, 292-295.
6. Couillard, C., Mauriege, P., Prud'homme, D., Nadeau, A., Tremblay, A., Bouchard, C. & Despres, J.-P. (1997) Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia, 40, 1178-1184.
7. Crook, M., Tutt, P. & Pickup, J.C. (1993a) Elevated serum sialic acid concentration in non-insulin-dependent diabetes and its relationship to blood pressure and retinopathy. Diabetes Care, 16, 57-60.
8. Crook, M.A., Tutt, P. & Pickup, J.C. (1993b) Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus. Clinica Chimica Acta, 219, 131-138.
9. de Courten, M., Zimmet, P., Hodge, A., Collins, V., Nicolson, M., Staten, M., Dowse, G. & Alberti, K.G.M.M. (1997) Hyperleptinaemia: the missing link in the metabolic syndrome? Diabetic Medicine, 14, 200-208.
10. Fried, S.K., Bunkin, D.A. & Greenburg, A.S. (1998) Omental and subcutaneous adipose tissue of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology and Metababolism, 83, 847-850.
11. Grunfeld, C., Zhao, C., Fuller, J., Pollock, A., Moser, A., Friedman, J. & Feingold, K.R. (1996) Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. Journal of Clinical Investigation, 97, 2152-2157.
12. Haffner, S.M., Stern, M.P., Miettinen, H., Wei, M. & Gingerich, R.L. (1996) Leptin concentrations in diabetic and nondiabetic Mexican-Americans. Diabetes, 45, 822-824.
13. Kushner, I. (1993) Regulation of the acute phase response by cytokines. Perspectives in Biology and Medicine, 36, 611-622.
14. Licinio, J., Mantzoros, C., Negrao, A.B., Cizza, G., Wong, M.-L., Bongiorno, P.B., Chrousos, G.P., Karp, B., Allen, C., Flier, J.S. & Gold, P.W. (1997) Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nature Medicine, 3, 575-579.
15. Panahloo, A., Mohammed-Ali, V., Lane, A., Green, F., Humphries, S.E. & Yudkin, J.S. (1995) Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene. Diabetes, 44, 37-42.
16. Papaspyrou-Rao, S., Schneider, S.H., Petersen, R.N. & Fried, S.K. (1997) Dexamethasone increases leptin expression in humans in vivo. Journal of Clinical Endocrinology and Metabolism, 82, 1635-1637.
17. Pickup, J.C. & Crook, M. (1998) Is type II diabetes a disease of the innate immune system? Diabetologia, 41, 1241-1248.
18. Pickup, J.C., Mattock, M.B., Chusney, G.D. & Burt, D. (1997a) NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia, 40, 1286-1292.
19. Pickup, J.C., Roberts, G.A., Kehely, A.M., Pasapula, C., Chusney, G.D. & Mather, H.M. (1997b) Higher serum sialic acid in women than men with NIDDM: possible relevance to increased cardiovascular risk in NIDDM women. Diabetes Care, 20, 1496.
20. Raynaud, E., Bran, J.-F., Perez-Martin, A. & Mercier, J. (1998) Association between fibrinogen levels and insulin resistance. Diabetes Care, 21, 2040-2041.
21. Rosenberg, A. & Schengrund, C.-L. (1976) Circulating sialyl compounds. In Biological Roles of Stalic Acid (eds. A. Rosenberg & S. Schengrund), pp. 275-294. Plenum, New York.
22. Sarraf, P., Fredrich, R.C., Turner, E.M., Ma, G., Jaskowiak, N.T., Rivett, D.J., Flier, J.S., Lowell, B.B. Fraker, D.L. & Alexander, H.R. (1997) Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. Journal of Experimental Medicine, 185, 171-175.
23. Simpson, H., Chusney, G.D., Crook, M.A. & Pickup, J.C. (1993) Serum sialic acid enzymatic assay based on microtitre plates. British Journal of Biomedical Science, 50, 164-167.
24. Slieker, L.J., Sloop, K.W., Surface, P.L., Kriauciunas, A., LaQuier, F., Manetta, J., Bue-Valleskey, J. & Stephens, T.W. (1995) Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. Journal of Biological Chemistry, 271, 5301-5304.
25. Taniuchi, K., Chifu, K., Hayashi, N., Nakamachi, Y., Yamaguchi, N., Uchida, Y., Tsukada, Y. & Sugimori, T. (1981) A new enzymatic method for the determination of sialic acid in serum and its application as a marker of acute phase reactants. Kobe Journal of Medical Science, 27, 91-102.
26. Torpy, D.J., Bornstein, S.R., Cizza, G. & Chrousos, G.P. (1998) The effects of glucocorticoids on leptin levels in humans may be restricted to acute pharmacological dosing. Journal of Clinical Endocrinology and Metabolism, 83, 1821-1822.
27. Tritos, N.A. & Mantzoros, C.S. (1997) Leptin: its role in obesity and beyond. Diabetologia, 40, 1371-1379.
28. Wabitsch, M., Jensen, P.B., Blum, W.F., Christoffersen, C.T., Englaro, P., Heinze, E., Rascher, W., Teller, W., Tornqvist, H. & Hauner, H. (1996) Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes, 45, 1435-1438.
29. Widén, E., Ekstrand, A., Saloranta, C., Franssila-Kalliunki, A., Eriksson, J., Schalin-Jantti, C. & Groop, L. (1992) Insulin resistance in type 2 (non-insulin-dependent) diabetic patients with hypertrigly-ceridaemia. Diabetologia, 35, 1140-1145.
30. Widjaja, A., Schurmeyer, T.H., von zur Muhlen, A. & Brabant, G. (1998) Determinents of serum leptin levels in Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 83, 600-603.
31. Zakrzewska, K.E., Cusin, I., Sainsbury, A., Rohner-Jeanrenaud, F. & Jeanrenaud, B. (1997) Glucocorticoids as counterregulatory hormones of leptin. Towards an understanding of leptin resistance. Diabetes, 46, 717-719.