Relationship of plasma HIV-RNA levels and levels of TNF-α and immune activation products in HIV infection

Clinical Immunology and Immunopathology

Volumn 84, Issue 1, 1997, Pages 36-45

  Salazar Gonzalez, Jesus F ^a,b   Martinez Maza, Otoniel ^a   Aziz, Najib ^a   Kolberg, Janice A ^c   Yeghiazarian, Torange ^c   Shen, Lu Ping ^c   Fahey, John L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD4 ANTIGEN; DIDANOSINE; NEOPTERIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; VIRUS REPLICATION;

EID: 0030739543     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1997.4364     Document Type: Article

References (36)

1. Fahey J. L., Taylor J. M. D., Detels R., Hofmann B., Melmed R., Nishanian P., Giorgi J. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N. Engl. J. Med. 322:1990;166-172.
2. Mellors J., Kingsley L. A., Rinaldo C. R., Todd J. A., Hoo B. S., Kokka R. P., Gupta. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconvertion. Ann. Int. Med. 122:1995;573-579.
3. Mellors J. W., Rinaldo C. R., Gupta P., White R. M., Todd J. A., Kingsley L. A. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science. 272:1996;1167-1170.
4. Piatak M., Saag M. S., Yang L. C., Clark S. J., Kappes J. C., Luk K.-C., Hahn B. H., Shaw G. M., Lifson J. D. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science. 259:1993;1749-1754.
5. Connor R. I., Mohri H., Cao Y., Ho D. D. Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1 infected individuals. J. Virol. 67:1993;1772-1777.
6. Pantaleo G., Graziosi C., Demarest J. F., Butini L., Montroni M., Fox C. H., Orenstein J. M., Kotler D. P., Fauci A. S. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature. 362:1993;355-358.
7. Fauci A. S., Schnittman S. M., Poli G. P., Koening S., Pantaleo G. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection. Ann. Intern. Med. 114:1991;678-693.
8. Matsuyama T., Kobayashi N., Yamamoto N. Cytokines and HIV infection: Is AIDS a tumor necrosis factor disease? AIDS. 5:1991;1405-1417.
9. Poli G., Kinter A., Justement J. S., Kehrl J. H., Bressler P., Stanley S., Fauci A. S. Tumor necrosis factor α functions in an autocrine manner in the induction of human immunodeficiency virus expression. Proc. Natl. Acad. Sci. USA. 87:1990;782-785.
10. Folks T. M., Clouse K. A., Justement J., Rabson A., Duh E., Hehrl J. H., Fauci A. S. Tumor necrosis factor-α induces expression of human immunodeficiency virus in a chronically infected T cell clone. Proc. Natl. Acad. Sci. USA. 86:1989;2365-2368.
11. Mellors J. W., Griffith B. P., Ortiz M. A., Landry M. L., Ryan J. L. Tumor necrosis factor-α/cachectin enhances human immunodeficiency virus type 1 replication in primary macrophages. J. Infect. Dis. 163:1991;78-82.
12. Herbein G., Keshav S., Collin M., Montaner L. J., Gordon S. HIV-1 induces tumor necrosis factor and IL-1 gene expression in primary human macrophages independent of productive infection. Clin. Exp. Immunol. 95:1994;442-449.
13. Dezube B. J., Pardee A. B., Beckett L. A., Ahlers C. M., Ecto L., Allen-Ryan J., Anisowicz A., Sager R., Crumpacker C. S. Cytokine dysregulation in AIDS: In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO. J. Acquir. Immune Defic. Syndr. 5:1992;1099-1104.
14. Wright S. C., Jewett A., Mitsuyasu R., Bonavida B. Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AIDS patients. J. Immunol. 141:1988;99-104.
15. Zangerle R., Gallati H., Sarcletti M., Wachter H., Fuchs D. Tumor necrosis alpha and soluble necrosis factor receptors in individuals with human immunodeficiency virus infection. Immunol. Lett. 41:1994;229-234.
16. Zangerle R., Gallati H., Sarcletti M., Wachter H., Fuchs D. Increased serum concentrations of soluble tumor necrosis factor receptors in HIV-infected individuals are associated with immune activation. J. Acquir. Immune Defic. Syndr. 7:1994;79-85.
17. Godfried M. H., Poll T. V. D., Weverling G. J., Mulder J. W., Jansen J., van Deventer S. J. H., Sauerwein H. P. Soluble receptors for tumor necrosis factor as predictors of progression to AIDS in asymptomatic human immunodeficiency virus type 1 infection. J. Infect. Dis. 169:1994;739-745.
18. Aukrust P., Liabakk N.-B., Muller F., Lien E., Espevik T., Frøland S. S. Serum levels of tumor necrosis factor-α (TNF-α) and soluble TNF receptors in human immunodeficiency virus type 1 infection - Correlations to clinical, immunologic, and virologic parameters. J. Infect. Dis. 169:1994;420-424.
19. Jansen J., van der Poll T., Levi M., Cate J. W. T., van Deventer S. J. H. Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-α antibody. J. Clin. Immunol. 15:1995;45-50.
20. Mohler K. M., Torrance D. S., Smith C. A., Goodwin R. G., Stremler K. E., Fung U. P., Madani H., Widmer M. B. Soluble tumor necrosis factor receptors are effective therapeutic agents in lethal endotoxin and function simultaneously as both TNF carriers and TNF antagonists. J. Immunol. 151:1993;1548-1561.
21. Todd J., Pachl C., White R., Yeghiazarian T., Johnson P., Taylor B., Holodniy M., Kern D., Hamren S., Chernoff D., Urdea M. Performance characteristics for the quantitation of plasma HIV-1 RNA using branched DNA amplification technology. J. Acquir. Immune Defic. Syndr. 10:1995;S35-S44.
22. Pachl C., Todd J. A., Kern D. G., Sheridan P. J., Fong S.-J., Stempien M., Hoo B., Besemer D., Yeghiazarian T., Irvine B., Kolberg J., Kokka R., Neuwald P., Urdea M. S. Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J. Acquir. Immune Defic. Syndr. 8:1995;446-454.
23. Giorgi J. V., Nishanian P. G., Schmid I., Hultin L. E., Cheng H. L., Detels R. Selective alterations in immunoregulatory lymphocyte subsets in early HIV (human T-lymphotropic virus type III/lymphadenopathy-associated virus) infection. J. Clin. Immunol. 7:1987;140-150.
24. Kolberg J., Shen L. P., Urdea M., Fahey J. L., Martinez-Maza O., Salazar-Gonzalez J. Quantitation of cellular mRNAs for TNF-α IL-6, IL-2 and IFNγ in HIV positive patients using bDNA assays (Abstract #B22). Eur. Cytokine Netw. 39:1995.
25. Running J. A., Urdea M. S. A procedure for productive coupling of synthetic oligonucleotides to polystyrene microtiter wells for hybridization capture. BioTechniques. 8:1990;276-277.
26. Klausner J. D., Makonkawkeyoon S., Akarasewi P., Nakata K., Kasinrerk W., Corral L., Dewar R. L., Lane H. C., Freedman V. H., Kaplan G. The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 andM. tuberculosis. J. Acquir. Immune Defic. Syndr. 11:1996;247-257.
27. Marfaing-Koka A., Aubin J.-T., Grangeot-Keros L., Portier A., Benattar C., Merrien D., Agut H., Aucouturier P., Autran B., Wijdenes J., Galanaud P., Dominique E. In vivo role of IL-6 on the viral load and on immunological abnormalities of HIV-infected patients. J. Acquir. Immune Defic. Syndr. 11:1996;59-68.
28. Melmed R. N., Taylor J. M. G., Detels R., Bozargmehri M., Fahey J. L. Serum neopterin changes in HIV-infected subjects: Indicator of significant pathology, CD4 T cell changes, and the development of AIDS. J. Acquir. Immune Defic. Syndr. 2:1989;70-76.
29. Hofmann B., Wang Y. X., Cumberland W. C., Detels R., Bozargmehri M., Fahey J. L. Serum β2-microglobulin levels increase in HIV-1 infection: Relation to seroconversion, CD4 T cell fall and prognosis of AIDS. AIDS. 4:1989;207-213.
30. Verhofstede C., Reniers S., Van Wanzeele F., Plum J. Evaluation of proviral copy number and plasma RNA levels as early indicators of progression in HIV-1 infection: Correlation with virologic and immunological markers of disease. AIDS. 8:1994;1421-1427.
31. Huber C., Batchelor J. R., Fuchs D., Hausen A., Lang A., Niederwieser D., Reibnegger G., Swetly P., Troppmair J., Wachter H. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon gamma. J. Exp. Med. 160:1984;310-316.
32. Fan J., Bass H. Z., Fahey J. L. Elevated IFN-γ and decreased IL2 gene expression are associated with HIV infection. J. Immunol. 151:1993;5031-5040.
33. Fuchs D., Hausen A., Reibnegger G., Werner E. R., Werner-Felmayer G., Dierich M. P., Wachter H. Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1. J. Acquir. Immune Defic. Syndr. 2:1989;158-162.
34. Yerly S., Chamot E., Hirschel B., Perrin L. H. Quantitation of human immunodeficiency virus provirus and circulating virus: Relationship with immunologic parameters. J. Infect. Dis. 166:1992;269-276.
35. Michael N. L., Vahey M., Burke D. S., Redfield A. R. Viral DNA and mRNA expression correlate with the stage of HIV-type 1 infection: Evidence for viral replication in all stages of disease. J. Virol. 66:1992;310-316.
36. Lefrère J. J., Mariotti M., Wattel E., Lefrère F., Inchauspe G., Costagliola D., Prince A. Towards a new predictor of AIDS progression through the quantitation of HIV-1 DNA copies by PCR in HIV-infected individuals. Br. J. Haematol. 82:1992;467-471.