메뉴 건너뛰기




Volumn 69, Issue 11, 1998, Pages 1291-1298

Effects of metronidazole plus amoxicillin in progressive untreated adult periodontitis: Results of a single 1-week course after 2 and 4 months

Author keywords

Amoxicillin therapeutic use; Clinical research; Double blind study; Metronidazole therapeutic use; Periodontitis therapy

Indexed keywords

AMOXICILLIN; METRONIDAZOLE; PLACEBO;

EID: 0031728884     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1998.69.11.1291     Document Type: Article
Times cited : (25)

References (46)
  • 1
    • 0023341175 scopus 로고
    • Clinical trials in periodontal therapy
    • Lindhe J, Nyman S. Clinical trials in periodontal therapy. J Periodont Res 1987;22:217-221.
    • (1987) J Periodont Res , vol.22 , pp. 217-221
    • Lindhe, J.1    Nyman, S.2
  • 2
    • 0018835177 scopus 로고
    • Effect of scaling and root planing on the composition of the human subgingival microbial flora
    • Mousqué T, Listgarten MA, Phillips RW. Effect of scaling and root planing on the composition of the human subgingival microbial flora. J Periodont Res 1980;15:144-151.
    • (1980) J Periodont Res , vol.15 , pp. 144-151
    • Mousqué, T.1    Listgarten, M.A.2    Phillips, R.W.3
  • 3
    • 0022053606 scopus 로고
    • Effects of scaling and root planing on subgingival microbial proportions standardized in terms of their naturally occurring distribution
    • Hinrichs JE, Wolff LF, Pihlstrom BL, Schaffer EM, Liljemark WF, Brandt CL. Effects of scaling and root planing on subgingival microbial proportions standardized in terms of their naturally occurring distribution. J Periodontol 1985;56:187-194.
    • (1985) J Periodontol , vol.56 , pp. 187-194
    • Hinrichs, J.E.1    Wolff, L.F.2    Pihlstrom, B.L.3    Schaffer, E.M.4    Liljemark, W.F.5    Brandt, C.L.6
  • 4
    • 0029803344 scopus 로고    scopus 로고
    • Microbiological response to mechanical treatment in combination with adjuntive therapy. A review of the literature
    • Bollen CML, Quirynen M. Microbiological response to mechanical treatment in combination with adjuntive therapy. A review of the literature. J Periodontol 1996;67:1143-1158.
    • (1996) J Periodontol , vol.67 , pp. 1143-1158
    • Bollen, C.M.L.1    Quirynen, M.2
  • 6
    • 0021240217 scopus 로고
    • Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks
    • Loesche WJ, Syed SA, Harrison EC, Kerry GA, Higgins T, Stoll J. Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks. J Periodontol 1984;55:325-335.
    • (1984) J Periodontol , vol.55 , pp. 325-335
    • Loesche, W.J.1    Syed, S.A.2    Harrison, E.C.3    Kerry, G.A.4    Higgins, T.5    Stoll, J.6
  • 7
    • 0019472184 scopus 로고
    • Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole
    • Loesche WJ, Syed SA, Morrison EC, Laughton B, Grossman NS. Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole. J Clin Periodontol 1981; 8:29-44.
    • (1981) J Clin Periodontol , vol.8 , pp. 29-44
    • Loesche, W.J.1    Syed, S.A.2    Morrison, E.C.3    Laughton, B.4    Grossman, N.S.5
  • 8
    • 0020616003 scopus 로고
    • Use of metronidazole as a probe in the study of human periodontal disease
    • Lindhe J, Liljenberg B, Adielson B, Börgesson I. Use of metronidazole as a probe in the study of human periodontal disease. J Clin Periodontol 1983;10:100-112.
    • (1983) J Clin Periodontol , vol.10 , pp. 100-112
    • Lindhe, J.1    Liljenberg, B.2    Adielson, B.3    Börgesson, I.4
  • 9
    • 0022879272 scopus 로고
    • A follow-up study 3 years after metronidazole therapy for chronic periodontal disease
    • Joyston-Bechal S, Smales FC, Duckworth R. A follow-up study 3 years after metronidazole therapy for chronic periodontal disease. J Clin Periodontol 1986;13:944-949.
    • (1986) J Clin Periodontol , vol.13 , pp. 944-949
    • Joyston-Bechal, S.1    Smales, F.C.2    Duckworth, R.3
  • 10
    • 0023917484 scopus 로고
    • Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial of sites with recurrent periodontal disease
    • Gusberti FA, Syed SA, Lang NP. Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial of sites with recurrent periodontal disease. J Clin Periodontol 1988; 15:353-359.
    • (1988) J Clin Periodontol , vol.15 , pp. 353-359
    • Gusberti, F.A.1    Syed, S.A.2    Lang, N.P.3
  • 11
    • 0025289227 scopus 로고
    • The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults
    • Soder PO, Frithiof L, Wikner S, et al. The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. J Periodontol 1990;61:281-288.
    • (1990) J Periodontol , vol.61 , pp. 281-288
    • Soder, P.O.1    Frithiof, L.2    Wikner, S.3
  • 12
    • 0022878508 scopus 로고
    • Metronidazole: A double-blind trial in untreated human periodontal disease
    • Watts T, Palmer R, Floyd P. Metronidazole: A double-blind trial in untreated human periodontal disease. J Clin Periodontol 1986;13: 939-943.
    • (1986) J Clin Periodontol , vol.13 , pp. 939-943
    • Watts, T.1    Palmer, R.2    Floyd, P.3
  • 14
    • 0028369255 scopus 로고
    • Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis
    • Pavicic MJAMP, van Winkelhoff AJ, Douqué NH, Steures RWR. de Graaff J. Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. J Clin Periodontol 1994;21:107-112.
    • (1994) J Clin Periodontol , vol.21 , pp. 107-112
    • Pavicic, M.J.A.M.P.1    Van Winkelhoff, A.J.2    Douqué, N.H.3    Steures, R.W.R.4    De Graaff, J.5
  • 16
    • 84987589773 scopus 로고
    • Clinical measurements of periodontitis
    • Goodson JM, Clinical measurements of periodontitis. J Clin Periodontol 1986;13:446-455.
    • (1986) J Clin Periodontol , vol.13 , pp. 446-455
    • Goodson, J.M.1
  • 17
    • 0022712398 scopus 로고
    • Attachment level changes in destructive periodontitis
    • Haffajee AD, Socransky SS. Attachment level changes in destructive periodontitis. J Clin Periodontol 1986;13:461-472.
    • (1986) J Clin Periodontol , vol.13 , pp. 461-472
    • Haffajee, A.D.1    Socransky, S.S.2
  • 18
    • 0020757054 scopus 로고
    • Comparison of statistical methods of analysis of data from clinical periodontal trials
    • Haffajee AD, Socransky SS, Lindhe J. Comparison of statistical methods of analysis of data from clinical periodontal trials. J Clin Periodontol 1983;10:247-256.
    • (1983) J Clin Periodontol , vol.10 , pp. 247-256
    • Haffajee, A.D.1    Socransky, S.S.2    Lindhe, J.3
  • 20
    • 0022297763 scopus 로고
    • Efficacy of clindamycin hydrochloride in refractory periodontitis
    • Gordon JM, Walker CB, Lamster I, et al. Efficacy of clindamycin hydrochloride in refractory periodontitis. J Periodontol 1985; 56(Suppl. 11):75-80.
    • (1985) J Periodontol , vol.56 , Issue.11 SUPPL. , pp. 75-80
    • Gordon, J.M.1    Walker, C.B.2    Lamster, I.3
  • 21
    • 0025186474 scopus 로고
    • Efficacy of clindamycin hydrochloride in refractory periodontitis: 24-month results
    • Gordon J, Walker C, Hovliaras C, Socransky S. Efficacy of clindamycin hydrochloride in refractory periodontitis: 24-month results. J Periodontol 1990;61:686-691.
    • (1990) J Periodontol , vol.61 , pp. 686-691
    • Gordon, J.1    Walker, C.2    Hovliaras, C.3    Socransky, S.4
  • 22
    • 0024442018 scopus 로고
    • Effect of non-surgical periodontal therapy combined with adjuntive antibiotics in subjects with "refractory" periodontal disease (I). Clinical results
    • Magnusson I, Clark WB, Low SB, Mariuniak J, Marks RG, Walker CB. Effect of non-surgical periodontal therapy combined with adjuntive antibiotics in subjects with "refractory" periodontal disease (I). Clinical results. J Clin Periodontol 1989;16:647-653.
    • (1989) J Clin Periodontol , vol.16 , pp. 647-653
    • Magnusson, I.1    Clark, W.B.2    Low, S.B.3    Mariuniak, J.4    Marks, R.G.5    Walker, C.B.6
  • 23
    • 0025011073 scopus 로고
    • Randomized control trial of doxycycline in prevention of recurrent periodontitis in high-risk patients: Antimicrobial activity and collagenase inhibition
    • McCulloch CAG, Birek P, Overall C, Aitken S, Lee W, Kulkarne GV. Randomized control trial of doxycycline in prevention of recurrent periodontitis in high-risk patients: antimicrobial activity and collagenase inhibition. J Clin Periodontol 1990;17:616-622.
    • (1990) J Clin Periodontol , vol.17 , pp. 616-622
    • McCulloch, C.A.G.1    Birek, P.2    Overall, C.3    Aitken, S.4    Lee, W.5    Kulkarne, G.V.6
  • 24
    • 0026099977 scopus 로고
    • A randomized placebo controlled clinical trial of doxycycline: Effect on the microflora of recurrent periodontitis lesions in high risk patients
    • Kulkarne GV, Lee WK, Aitken S, Birek P, McCulloch CA. A randomized placebo controlled clinical trial of doxycycline: Effect on the microflora of recurrent periodontitis lesions in high risk patients. J Periodontol 1991;62:197-202.
    • (1991) J Periodontol , vol.62 , pp. 197-202
    • Kulkarne, G.V.1    Lee, W.K.2    Aitken, S.3    Birek, P.4    McCulloch, C.A.5
  • 25
    • 0027321648 scopus 로고
    • A role for antibiotics in the treatment of refractory periodontitis
    • Walker C, Gordon J, Magnusson I, Clark WB. A role for antibiotics in the treatment of refractory periodontitis. J Periodontol 1993;64: 772-781.
    • (1993) J Periodontol , vol.64 , pp. 772-781
    • Walker, C.1    Gordon, J.2    Magnusson, I.3    Clark, W.B.4
  • 26
    • 0029349715 scopus 로고
    • Clinical and microbiological changes associated with the use of 4 adjunctive systemically administered agents in the treatment of periodontal infections
    • Haffajee AD, Dibart S, Kent RL Jr, Socransky SS. Clinical and microbiological changes associated with the use of 4 adjunctive systemically administered agents in the treatment of periodontal infections. J Clin Periodontol 1995;22:681-627.
    • (1995) J Clin Periodontol , vol.22 , pp. 681-1627
    • Haffajee, A.D.1    Dibart, S.2    Kent Jr., R.L.3    Socransky, S.S.4
  • 28
    • 0017103383 scopus 로고
    • Chemotherapy of dental plaque infections
    • Loesche, WJ. Chemotherapy of dental plaque infections. Oral Sci Rev 1976;9:65-107.
    • (1976) Oral Sci Rev , vol.9 , pp. 65-107
    • Loesche, W.J.1
  • 29
    • 0020645262 scopus 로고
    • Antimicrobial susceptibilities of bacteria associated with periodontal disease
    • Sutter VL, Jones JM, Ghomien AT. Antimicrobial susceptibilities of bacteria associated with periodontal disease. Antimicrob Agents Chemother 1983;23:483-486.
    • (1983) Antimicrob Agents Chemother , vol.23 , pp. 483-486
    • Sutter, V.L.1    Jones, J.M.2    Ghomien, A.T.3
  • 30
    • 0020967839 scopus 로고
    • Antibiotic susceptibility testing on subgingival plaque samples
    • Walker CB, Gordon JM, Socransky SS. Antibiotic susceptibility testing on subgingival plaque samples. J Clin Periodontol 1983;10:422-432.
    • (1983) J Clin Periodontol , vol.10 , pp. 422-432
    • Walker, C.B.1    Gordon, J.M.2    Socransky, S.S.3
  • 31
    • 0022323080 scopus 로고
    • Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents
    • Walker CB, Pappas JD, Tyler KZ, Cohen S, Gordon JM. Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents. J Periodontol 1985;56(Suppl.):67-74.
    • (1985) J Periodontol , vol.56 , Issue.SUPPL. , pp. 67-74
    • Walker, C.B.1    Pappas, J.D.2    Tyler, K.Z.3    Cohen, S.4    Gordon, J.M.5
  • 32
    • 0028457303 scopus 로고
    • Antimicrobial strategies for treatment of periodontal diseases
    • Goodson JM. Antimicrobial strategies for treatment of periodontal diseases. Periodontol 2000 1994;5:142-168.
    • (1994) Periodontol 2000 , vol.5 , pp. 142-168
    • Goodson, J.M.1
  • 34
    • 0027292514 scopus 로고
    • Current status of systemic antibiotic usage in destructive periodontal disease
    • Gordon JM, Walker CB. Current status of systemic antibiotic usage in destructive periodontal disease. J Periodontol 1993;64:760-771.
    • (1993) J Periodontol , vol.64 , pp. 760-771
    • Gordon, J.M.1    Walker, C.B.2
  • 35
    • 0022608232 scopus 로고
    • Clinical and microbiological effects of single-dose metronidazole or scaling and root planing in the treatment of adult periodontitis
    • Walsh MM, Buchanan SA, Hoover C, et al. Clinical and microbiological effects of single-dose metronidazole or scaling and root planing in the treatment of adult periodontitis. J Clin Periodontol 1986;13:151-157.
    • (1986) J Clin Periodontol , vol.13 , pp. 151-157
    • Walsh, M.M.1    Buchanan, S.A.2    Hoover, C.3
  • 37
    • 0022421927 scopus 로고
    • Metronidazole as an adjunct to periodontal therapy with subgingival curettage
    • Sterry KA, Langeroudi M, Dolby AE. Metronidazole as an adjunct to periodontal therapy with subgingival curettage. Br Dent J 1985; 158:176-178.
    • (1985) Br Dent J , vol.158 , pp. 176-178
    • Sterry, K.A.1    Langeroudi, M.2    Dolby, A.E.3
  • 38
    • 0023250372 scopus 로고
    • Microbial and clinical measurements of periodontal pockets during sequential periods of non-treatment, mechanical debridement and metronidazole therapy
    • Van Oosten MA, Mikx FH, Renggli HH. Microbial and clinical measurements of periodontal pockets during sequential periods of non-treatment, mechanical debridement and metronidazole therapy. J Clin Periodontol 1987;14:197-204.
    • (1987) J Clin Periodontol , vol.14 , pp. 197-204
    • Van Oosten, M.A.1    Mikx, F.H.2    Renggli, H.H.3
  • 40
    • 0016793324 scopus 로고
    • The effects of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced disease
    • Lindhe J, Nyman S. The effects of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced disease. J Clin Periodontol 1975;2:67-79.
    • (1975) J Clin Periodontol , vol.2 , pp. 67-79
    • Lindhe, J.1    Nyman, S.2
  • 41
    • 0017282649 scopus 로고
    • The effect of systematic plaque control on bone regeneration in infrabony pockets
    • Rosling B, Nyman S., Lindhe J. The effect of systematic plaque control on bone regeneration in infrabony pockets. J Clin Periodontol 1976;3:38-530.
    • (1976) J Clin Periodontol , vol.3 , pp. 38-530
    • Rosling, B.1    Nyman, S.2    Lindhe, J.3
  • 42
    • 0029311601 scopus 로고
    • Supragingival dental plaque in the etiology of oral diseases
    • Shibly O, Rifai S, Zambon J. Supragingival dental plaque in the etiology of oral diseases. Periodontol 2000 1995;8:42-59.
    • (1995) Periodontol 2000 , vol.8 , pp. 42-59
    • Shibly, O.1    Rifai, S.2    Zambon, J.3
  • 43
    • 0012346591 scopus 로고
    • Metronidazole in acute ulcerative gingivitis
    • Shinn DLS. Metronidazole in acute ulcerative gingivitis. Lancet 1962;1:1101.
    • (1962) Lancet , vol.1 , pp. 1101
    • Shinn, D.L.S.1
  • 45
    • 0031603004 scopus 로고    scopus 로고
    • Differential effects of metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats
    • Flemmig TF, Milián E, Kopp C, Karch H, Klaiber B. Differential effects of metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats. J Clin Periodontol 1998;25:1-10.
    • (1998) J Clin Periodontol , vol.25 , pp. 1-10
    • Flemmig, T.F.1    Milián, E.2    Kopp, C.3    Karch, H.4    Klaiber, B.5
  • 46
    • 0026638418 scopus 로고
    • Establishment of aging biofilms: A possible mechanism of bacterial resistance to antimicrobial therapy
    • Anwar H, Strap JL, Costerton JW. Establishment of aging biofilms: a possible mechanism of bacterial resistance to antimicrobial therapy. Antimicrob Agents Chemother 1992;36:1347-1351.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1347-1351
    • Anwar, H.1    Strap, J.L.2    Costerton, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.