Systemic doxycycline administration in the treatment of periodontal infections (I). Effect on the subgingival microbiota

Journal of Clinical Periodontology

Volumn 26, Issue 12, 1999, Pages 775-783

  Feres, M ^a   Haffajee, A D ^a   Goncalves, C ^a   Allard, K A ^a   Som, S ^a   Smith, C ^a   Goodson, J M ^a   Socransky, S S ^a  

^a FORSYTH INSTITUTE   (United States)

Author keywords

Antibiotic; Bacteria; Doxycycline; Microbiology; Periodontal diseases; Periodontitis; Subgingival plaque

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE;

ADULT; ARTICLE; BACTERIUM; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GINGIVA; HUMAN; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TIME; TOOTH PLAQUE;

ADULT; ANTI-BACTERIAL AGENTS; BACTERIA; DENTAL PLAQUE; DOXYCYCLINE; FEMALE; GINGIVA; HUMANS; MALE; MIDDLE AGED; PERIODONTAL POCKET; SINGLE-BLIND METHOD; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 0033253636     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.1999.tb02520.x     Document Type: Article

References (65)

1. Asikainen, S., Jousimies-Somer, H., Kanervo, A. & Saxen, L. (1990) The immediate efficacy of adjunctive doxycycline in treatment of localized juvenile periodontitis. Archives of Oral Biology 35, 231S-234S.
2. Anwar, H., Dasgupta, M., Lam, K. & Costerton. J.W. (1989a) Tobramycin resistance of mucoid Pseudomonas aeruginosa biofilm grown under iron limitation. Journal of Antimicrobial Chemotherapy 24, 647-655.
3. Anwar, H., van Biesen, T., Dasgupta, M., Lam, K. & Costerton, J. W. (1989b) Interaction of biofilm bacteria with antibiotics in a novel in vitro chemostat system. Antimicrobial Agents & Chemotherapy 33, 1824-1826.
4. Anwar, H., Strap, J. L. & Costerton, J. W. (1992) Establishment of aging biofilms: a possible mechanism of bacterial resistance to antibiotic therapy. Antimicrobial Agents & Chemotherapy 36, 1347-1351.
5. Brown, M. R. W., Allison, D. G. & Gilbert, P. (1988) Resistance of bacterial biofilms to antibiotics: a growth-rate related effect? Annual Review of Microbiology 39, 527-556.
6. Christersson, L. A. & Zambon, J. J. (1993) Suppression of subgingival Actinobacillus actinomycetemcomitans in localized juvenile periodontitis by systemic tetracycline. Journal of Clinical Periodontology 20, 395-401.
7. Clark, D. C., Shenker, S., Stulginsky, P. & Schwartz, S. (1983) Effectiveness of routine periodontal treatment with and without adjunctive metronidazole therapy in mentally retarded adolescents. Journal of Periodontology 54, 658-665.
8. Colombo, A. P., Haffajee, A. D., Dewhirst, F. E., Paster, B. J., Smith, C. M., Cugini, M. A. & Socransky, S. S. (1998) Clinical and microbiological features of refractory periodontitis. Journal of Clinical Periodontology 25, 169-180.
9. Costerton, J. W., Irvin, R. T. & Cheng, K.-J. (1981) The bacterial glycocalyx in nature and disease. Annual Review of Microbiology 35, 299-324.
10. Costerton, J. W., Lewandowski, Z., Caldwell, D. E., Korber, D. R. & Lappin-Scott, H. M. (1995) Microbial biofilms. Annual Review of Microbiology 49, 711-745.
11. Crout, R. J., Lee, L. M., Schroeder, K., Crout, H., Ramamurthy, N. S., Wiener, M. & Golub, L. M. (1996) The "cyclic" regimen of low-dose doxycycline for adult periodontitis: a preliminary study. Journal of Periodontology 67, 506-514.
12. Cugini, M. A., Haffajee, A. D., Smith, C., Kent, R. L. Jr. & Socransky, S. S. (2000) The effect of SRP on the clinical and microbiological parameters of periodontal diseases. 12 month results. Journal of Clinical Periodontology 27, in press.
13. Feres, M., Haffajee, A. D., Goncalves, C., Allard, K. A., Som, S., Smith, C., Goodson, J. M. & Socransky, S. S. (1999) Systemic doxycycline administration in the treatment of periodontal infections. II Effect on antibiotic resistance of subgingival species. Journal of Clinical Periodontology, in press.
14. Genco, R.J. Antibiotics in the treatment of human periodontal diseases. (1981) Journal of Periodontology 52, 545-558.
15. Giedrys-Leeper, E., Selipsky, H. & Williams, B.L. (1985) Effects of short-term administration of metronidazole on the subgingival microflora. Journal of Clinical Periodontology 12, 797-814.
16. Gordon, J., Walker, C., Hovliaras, C. & Socransky, S. (1990) Efficacy of clindamycin hydrochloride in refractory periodontitis: 24-month results. Journal of Periodontology 61, 686-691.
17. Gordon, J. M., Walker, C. B., Lamster, I., West, T., Socransky, S., Seiger, M. & Fasciano, R. (1985) Efficacy of clindamycin hydrochloride in refractory periodontitis, 12-month results. Journal of Periodontology 56 (11 suppl), 75-80.
18. Haffajee, A. D., Cugini, M. A., Dibart, S., Smith, C., Kent, R.L. Jr. & Socransky S.S. (1997) The effect of SRP on the clinical and microbiological parameters of periodontal diseases. Journal of Clinical Periodontology 24, 324-334.
19. Haffajee, A. D., Cugini, M. A., Tanner, A., Pollack, R. P., Smith, C., Kent, R. L. Jr. & Socransky S. S. (1998) Subgingival microbiota in healthy, well-maintained elder and periodontitis subjects Journal of Clinical Periodontology 25, 346-353.
20. Haffajee, A. D., Dibart, S., Kent, R. L. Jr. & Socransky, S. S. (1995) Clinical and microbiological changes associated with the use of 4 adjunctive systemically administered agents in the treatment of periodontal infections. Journal of Clinical Periodontology 22, 618-627.
21. Haffajee, A. D., Socransky, S. S., Dibart, S. & Kent, R. L. Jr. (1996) Response to periodontal therapy in patients with high or low levels of P. gingivalis. P. intermedia, P. nigrescens and B. forsythus. Journal of Clinical Periodontology 23, 336-345.
22. Haffajee, A. D., Socransky, S. S., Dzink, J. L., Taubman, M. A. & Ebersole, J. L. (1988) Clinical, microbiological and immunological features of subjects with refractory periodontal diseases. Journal of Clinical Periodontology 15, 390-398.
23. Haffajee, A. D., Socransky, S. S., Ebersole, J. L. & Smith, D. J. (1984) Clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions. Journal of Clinical Periodontology 11, 600-618.
24. Haffajee, A. D., Socransky, S. S. & Goodson, J.M. (1983) Comparison of different data analyses for detecting changes in attachment level. Journal of Clinical Periodontology 10, 298-310.
25. Hellden, L. B., Listgarten, M. A. & Lindhe, J. (1979) The effect tetracycline and/or scaling on human periodontal disease. Journal of Clinical Periodontology 6, 222-230.
26. Hoyle, B. D. & Costerton, J. W. (1989) Transient exposure to a physiologically-relevant concentration of calcium confers tobramycin resistance upon sessile cells of Pseudomonas aeruginosa. FEMS Microbiology Letters 60, 339-342.
27. Hoyle, B. D., Jass, J. & Costerton, J. W. (1990) The biofilm glycocalyx as a resistance factor. Journal of Antimicrobial Chemotherapy 26, 1-6.
28. Jenkins, W. M. M., MacFarlane, P. W., Gilmour, W. H., Ramsy, I. & MacKenzie, D. (1989) Systemic metronidazole in the treatment of periodontitis. Journal of Clinical Periodontology 16, 443-450.
29. Kornman, K. S. & Karl, E. H. (1982) The effect of long-term, low-dose tetracycline therapy on the subgingival microflora in refractory adult periodontitis. Journal of Periodontology 53, 604-610.
30. Kornman, K. S. & Robertson, P. B. (1985) Clinical and microbiological evaluation of therapy for juvenile periodontitis. Journal of Periodontology 56, 443-446.
31. Kunihira, D. M., Caine, F. A., Palcanis, K. G., Best, A. M & Ranney, R. R. (1985) A clinical trial of phenoxymethyl penicillin for adjunctive treatment of juvenile periodontitis. Journal of Periodontology 56, 352-358.
32. Lee, L. M., Golub, L. M., Chan, D., Leung, M., Schroeder, K., Wolff, M., Simon, S. & Crout, R. (1997) 1-Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition of doxycycline. Journal of Periodontal Research 32, 9-19.
33. Liljenberg, B. & Lindhe, J. (1980) Juvenile periodontitis. Some microbiological, histopathological and clinical characteristics. Journal of Clinical Periodontology 7: 48-61.
34. Lindhe, J., Liljenberg, B. & Adielson, B. (1983) Effect of long term tetracycline therapy on human periodontal disease. Journal of Clinical Periodontology 10, 590-601.
35. Lindhe, J. & Liljenberg, B. (1984) Treatment of localized juvenile periodontitis. Results after 5 years. Journal of Clinical Periodontology 11, 399-410.
36. Listgarten, M. A., Lindhe, J. & Hellden, L. (1978) Effect of tetracycline and/or scaling on human periodontal disease. Clinical, microbiological, and histopathological observations. Journal of Clinical Periodontology 5, 246-271.
37. Magnusson, I., Clark, W. B., Low, S. B., Mariuniak, J., Marks, R. G. & Walker, C. B. (1989) Effect of non-surgical periodontal therapy combined with adjunctive antibiotics in subjects with "refractory" periodontal disease (I). Clinical results. Journal of Clinical Periodontology 16, 647-653.
38. Magnusson, I., Marks, R. G., Clark, W. B., Walker, C. B., Low, S. B. & McArthur, W. P. (1991) Clinical, microbiological and immunological characteristics of subjects with "refractory" periodontal disease. Journal of Clinical Periodontology 18, 291-299.
39. Mandell, R. L. & Socransky, S. S. (1988) Microbiological and clinical effects of surgery plus doxycycline on juvenile periodontitis. Journal of Periodontology 59, 373-379.
40. Mandell, R. L., Tripodi, L. S., Savitt, E., Goodson, J. M. & Socransky, S. S. (1986) The effect of treatment on Actinobacillus actinomycetemcomitans in localized juvenile periodontitis. Journal of Periodontology 57, 94-99.
41. Nichols, W. W., Evans, M. J., Slack, M. P. E. & Walmsley, H.L. (1989) The penetration of antibiotics into aggregates of mucoid and non-mucoid Pseudomonas aeruginosa. Journal of General Microbiology 135, 1291-1303.
42. Nickel, J. C., Ruseska, J., Wright, J. B. & Costerton, J. W. (1985) Tobramycin resistance of Pseudomonas aeruginosa cells growing as a biofilm on urinary catheter material. Antimicrobial Agents & Chemotherapy 27, 619-624.
43. Novak, M. J., Polson, A. M. & Adair, S. M. (1989) Tetracycline therapy in patients with early periodontitis Journal of Periodontology 59, 366-372.
44. Novak, M. J., Stamataelakys, C. & Adair, S. M. (1991) Resolution of early lesions of juvenile periodontitis. Journal of Periodontology 62, 628-633.
45. Olsvik, B., Flynn, M. J., Tenover, F. C., Slots, J. & Olsen, I. (1996a) Tetracycline-resistance in Prevotella isolates from periodontally diseased patients is due to tet(Q) gene. Oral Microbiology & Immunology 11, 304-308.
46. Olsvik, B., Olsen, I. & Tenover, F. C. (1994) The tet(Q) gene in bacteria isolated from patients with refractory periodontal disease. Oral Microbiology & Immunology 9, 251-255.
47. Olsvik, B., Olsen, I. & Tenover, F. C. (1995a) Detection of tet(M) and tet(O) using the polymerase chain reaction in bacteria isolated from patients with periodontal disease. Oral Microbiology & Immunology 10, 87-92.
48. Olsvik, B., Olsen, I & Tenover, F. C. (1995b) Tetracycline-resistant microorganisms recovered from patients with refractory periodontal disease. Journal of Clinical Periodontology 12, 391-396.
49. Olsvik, B., Tenover, F. C., Olsen, I. & Rasheed, J. K. (1996b) Three subtypes of the tet(M) gene identified in bacterial isolates from periodontal pockets. Oral Microbiology & Immunology 11, 299-303.
50. Papli, R. & Lewis, J. M. (1989) Refractory periodontitis: effect of oral tetracycline hydrochloride and root planing. Australian Dental Journal 34, 60-68.
51. Roberts, M. C. & Lansciardi, J. (1990) Transferrable tet(M) in Fusobacterium nucleatum. Antimicrobial Agents & Chemotherapy 34, 1836-1838.
52. Roberts, M. C. & Moncla D. J. (1988) Tetracycline resistance and tet(M) in oral anaerobic bacteria and Neisseria perflava-N. sicca. Antimicrobial Agents & Chemotherapy 32, 1271-1273.
53. Saxen, L. & Asikainen, S. (1993) Metronidazole in the treatment of localized juvenile periodontitis. Journal of Clinical Periodontology 20, 166-171.
54. Saxen, L., Asikainen, S., Kanervo, A., Kari, K. & Jousimies-Somer, H. (1990) The long-term efficacy of systemic doxycycline medication in the treatment of localized juvenile periodontitis. Archives Oral Biology 35, Suppl: 227S-229S.
55. Scopp, I. W., Froum, S. J., Sullivan, M., Kazandjian, G., Wank, D. & Fine, A. (1980) Tetracycline: a clinical study to determine its effectiveness as long-term adjuvant. Journal of Periodontology 51, 328-330.
56. Slots, J., Feik, D. & Rams, T. E. (1990) Prevalence and antimicrobial susceptibility of Enterobacteriaceae, Pseudomonadaceae and Acinetobacter in human periodontitis. Oral Microbiology & Immunology 5, 149-154.
57. Slots, J. & Rosling, B. G. (1983) Suppression of the periodontopathic microflora in localized juvenile periodontitis by systemic tetracycline. Journal of Clinical Periodontology 10, 465-486.
58. Socransky, S. S., Smith, C., Martin, L., Paster, B. J., Dewhirst, F. E. and Levin, A. E. (1994) Checkerboard DNA-DNA hybridization. Biotechniques, 17, 788-792.
59. Sterry, K. A., Langeroudi, M. & Dolby, A. E. (1985) Metronidazole as an adjunct to periodontal therapy with subgingival curettage. British Dental Journal 158, 176-178.
60. Van Winkelhoff, A. J., Rams, T. E. & Slots, J. (1996) Systemic antibiotic therapy in periodontics. Periodontology 2000 10, 45-78.
61. Van Winkelhoff, A. J., Rodenburg, J. P., Goene, R. J., Abbas, E, Winkel, E. G., & De Graaff, J. (1989) Metronidazole plus amoxicillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. Journal of Clinical Periodontology 16, 128-131.
62. Van Winkelhoff, A. J., Tijhof, C. J. & de Graaff, J. (1992) Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. Journal of Periodontology 63, 52-57.
63. Walker, C. B. (1996) The acquisition of antibiotic resistance in periodontal microflora. Periodontology 2000 10, 79-88.
64. Walker, C. & Gordon, J. (1990) The effect of clindamycin on the microbiota associated with refractory periodontitis. Journal of Periodontology 61, 692-698.
65. Walker, C., Gordon, J., Magnusson, I. & Clark, W.B. (1993) A role for antibiotics in the treatment of refractory periodontitis. Journal of Periodontology 64, 772-781.