Transient anti-CD154-mediated immunotherapy of ongoing relapsing experimental autoimmune encephalomyelitis induces long-term inhibition of disease relapses

Journal of Neuroimmunology

Volumn 129, Issue 1-2, 2002, Pages 58-65

  Howard, Laurence M ^a   Dal Canto, Mauro C ^a   Miller, Stephen D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Autoimmunity; CD40; Delayed type hypersensitivity; EAE MS; Epitope spreading; Immunotherapy

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; EPITOPE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; IMMUNE RESPONSE; IMMUNOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECURRENT DISEASE; T LYMPHOCYTE;

ANIMALS; ANTIBODIES; ANTIGENS, CD40; CD40 LIGAND; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNOTHERAPY; LYMPH NODES; MICE; MICE, INBRED STRAINS; SPLEEN; TH1 CELLS;

EID: 0036344002     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00175-3     Document Type: Article

References (27)

1. CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice
2. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system
3. Relapsing experimental allergic encephalomyelitis in the SJL/J mouse
4. Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction
5. Primary demyelination in Theiler's virus infection. An ultrastructural study
6. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40
7. Inflammation in EAE: Role of chemokine/cytokine expression by resident and infiltrating cells
8. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis
9. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
10. The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells
11. Autoimmune intervention by CD154 blockade prevents T cell retention and effector function in the target organ
12. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
13. Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis
14. Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells
15. Induction of active and adoptive chronic-relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein
16. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
17. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
18. Multiple sclerosis and central nervous system demyelination
19. Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions
20. Multiple sclerosis: Distribution of T cell subsets and Ia-positive macrophages in lesions of different ages
21. Diversity and plasticity of self recognition during the development of multiple sclerosis
22. Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis
23. Epitope spreading
24. Role of epitope spreading in immune-mediated diseases: Implications for specific immunotherapy
25. The functional significance of epitope spreading and its regulation by co-stimulatory molecules
26. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis
27. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease