Genetics of childhood cancer

Clinical Orthopaedics and Related Research

Volumn 401, Issue , 2002, Pages 75-87

  Ganjavi, Hooman ^a   Malkin, David ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER DIAGNOSIS; CANCER GENETICS; CARCINOGENESIS; CHILDHOOD CANCER; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; DNA REPAIR; FUSION GENE; GENE MUTATION; GROWTH REGULATION; LEUKEMIA; MOLECULAR GENETICS; ONCOGENE; PRIORITY JOURNAL; PROGNOSIS; SOLID TUMOR; TREATMENT PLANNING; TUMOR SUPPRESSOR GENE;

EID: 0036334886     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-200208000-00011     Document Type: Conference Paper

References (53)

1. ASHG/ACMG report. Points to consider: Ethical, legal, and psychosocial implications of genetic testing in children and adolescents
2. Chromosomal translocations in Ewing's sarcoma
3. Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age
4. The molecular biology of cancer
5. Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families
6. Spectrum of germline mutations in the RBI gene: A study of 232 patients with hereditary and non hereditary retinoblastoma
7. Nucleotide excision repair syndromes: Xeroderma pigmentosum, cockayne syndrome and trichothiodystrophy
8. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
9. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
10. ATM mutations in B-cell chronic lymphocytic leukemia
11. Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome
12. ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy
13. Prognostic relevance of ALL-1 gene rearrangement in infant acute leukemias
14. A summary of mutations in the UV-sensitive disorders: Xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy
15. Philadelphia chromosome positive childhood acute lymphoblastic leukemia: Clinical and cytogenetic characteristics and treatment outcome: A Pediatric Oncology Group study
16. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
17. Inherited susceptibility to breast cancer
18. Translocation (9;22) is associated with extremely poor prognosis in intensively treated children with acute lymphoblastic leukemia
19. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
20. Regulation of Mdm2-directed degradation by the C terminus of p53
21. Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma
22. Tumors associated with p53 germline mutations: A synopsis of 91 families
23. Mutation and cancer: Statistical study of retinoblastoma
24. Sunlight and skin cancer: Another link revealed
25. Soft-tissue sarcomas, breast cancer, and other neoplasms: A familial syndrome?
26. A cancer family syndrome in twenty-four kindreds
27. Spectrum of small length germline mutations in the RBI gene
28. Ataxia-telangiectasia and T-cell leukemias: No evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL
29. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
30. Cancers in 44 families with ataxia-telangiectasia
31. Cytogenetic abnormalities in childhood acute lymphoblastic leukemia correlates with clinical features and treatment outcome
32. 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukaemia
33. Current status of cytogenetic research in childhood acute lymphoblastic leukaemia
34. Cytogenetics of pro-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19)
35. Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy
36. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML 1 gene fusion
37. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia
38. Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: A Pediatric Oncology Group study
39. TEL gene rearrangement in acute lymphoblastic leukemia: A new genetic marker with prognostic significance
40. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
41. Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma
42. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis
43. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
44. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia
45. Inactivation of the ATM gene in T-cell prolymphocytic leukemias
46. Defective bypass replication of a leading strand cyclobutane thymine dimer in xeroderma pigmentosum variant cell extracts
47. Breast and other cancers in families with ataxia-telangiectasia
48. Incidence of cancer in 161 families affected by ataxiatelangiectasia
49. Nucleotide excision repair: Its relation to human disease
50. Chromosomes in Ewing's sarcoma: I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12)
51. Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia
52. Cancer incidence, survival, and mortality for children younger than age 15 years
53. ATM is usually rearranged in T-cell prolymphocytic leukaemia