Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age

Blood

Volumn 87, Issue 7, 1996, Pages 2870-2877

  Behm, F G ^a   Raimondi, S C ^b   Frestedt, J L ^b   Liu, Q ^b   Crist, W M ^b   Downing, J R ^b   Rivera, G K ^b   Kersey, J H ^b   Pui, C H ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; DNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; AGE; ARTICLE; CANCER SURVIVAL; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 11Q; CHROMOSOME DELETION; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; GENE REARRANGEMENT; HUMAN; HUMAN CELL; INFANT; PRIORITY JOURNAL; PROGNOSIS;

EID: 0029897897     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.7.2870.bloodjournal8772870     Document Type: Article

References (30)

1. Raimondi SC, Peiper SC, Kitchingman GR, Behm FG, Williams DL, Hancock ML, Mirro J: Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23. Blood 73:1627, 1989
2. Akao Y, Seto M, Yamamoto K, Iida S, Nakazawa S, Inazawa J, Abe T, Takahashi T, Ueda R: The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) translocations. Cancer Res 52:6083, 1992
3. Radice P, Tunnacliffe A: Distinct breakpoints in band 11q23 of the t(4;11) and t(11;14) associated with leukocyte malignancy. Genes Chromosom Cancer 5:50, 1992
4. Chen Z, Brand NJ, Chen A, Chen S-J, Tong J-H, Wang Z-Y, Waxman S, Zelent A: Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor a locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 12:1161, 1993
5. Burnett RC, Espinosa R III, Shows TB, Eddy RL, LeBeau MM, Rowley JD, Diaz MO: Molecular analysis of a t(11;14) (q23;q11) from a patient with null-cell acute lymphoblastic leukemia. Genes Chromosom Cancer 7:38, 1993
6. Height SE, Dainton MG, Kearney L, Swansbury GJ, Matutes E, Dyer MJS, Treleaven JG, Powles RL, Catovsky D: Acute myelomonocytic leukemia with t(10;11)(p13;q23): heterogeneity of breakpoints at 11q23 and association with recombinase activation. Genes Chromosom Cancer 11:136, 1994
7. Zieman-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel S, Harden A, Rubinelli P, Smith SD, LeBeau MM, Rowley JD, Diaz MO: Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 88:10735, 1991
8. Cimino G, Moir DT, Canaani O, Williams K, Crist WM, Katzav S, Cannizzaro L, Lange B, Nowell PC, Croce CM, Canaani E: Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations. Cancer Res 51:6712, 1991
9. Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van der Poel S, Kaneko Y, Morgan R, Sandberg AA, Chaganti RSK, Larson RA, LeBeau MM, Diaz MO, Rowley JD: Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 329:909, 1993
10. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E: The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71:701, 1992
11. Tkachuk DC, Kohler S, Cleary ML: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71:691, 1992
12. Rubnitz JE, Link MP, Shuster JJ, Carroll AJ, Hakami N, Frankel LS, Pullen DJ, Cleary ML: Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: A Pediatric Oncology Group Study. Blood 84:570, 1994
13. Raimondi SC, Frestedt JL, Pui C-H, Downing JR, Head DR, Kersey JH, Behm FG: Acute lymphoblastic leukemia with deletion of 11q23 or novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features. Blood 86:1881, 1995
14. Pui C-H, Behm FG, Downing JR, Hancock ML, Shurtleff SA, Ribeiro RC, Head DR, Mahmoud HH, Sandlund JT, Furman WL, Roberts WM, Crist WM, Raimondi SC: 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J Clin Oncol 12:909, 1994
15. Chen C-S, Sorensen PHB, Domer PH, Reaman GH, Korsmeyer SJ, Heerema NA, Hammond GD, Kersey JH: Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 81:2386, 1993
16. Evans WE, Rodman J, Relling MV, Crom WR, Rivera GK, Crist WM, Pui C-H: Individual dosages of chemotherapy as a strategy to improve response for acute lymphocytic leukemia. Semin Hematol 28:15, 1991
17. Pui C-H, Relling MV, Behm FG, Hancock ML, Boyett JH, Raimondi SC, Krance RA, Mahmoud H, Riberio RL, Sandlund JT, Head DR, Evans WE, Crist WM, Rivera GK: L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins. Leukemia (in press)
18. Bennett JC, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: The French-American-British (FAB) Cooperative Group: The morphologic classification of acute lymphoblastic leukemia: Concordance among observers and clinical correlations. Br J Haematol 47:553, 1981
19. Williams DL, Harris A, Williams KJ, Brosius MJ, Lemonds W: A direct bone marrow chromosome technique for acute lymphoblastic leukemia. Cancer Genet and Cytogenet 13:329, 1984
20. ISCN: in Mitelman F (ed): Guidelines for Cancer Cytogenetics, Supplement to An International System for Human Cytogenetic Nomenclature. Basel, Switzerland, Karger, 1991, p 1
21. Behm FG, Raimondi SC, Schell MJ, Look AT, Rivera GK, Pui C-H: Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features. Blood 79:1011, 1992
22. Sorensen PHB, Chen C-S, Smith FO, Arthur DC, Domer PH, Bernstein ID, Korsmeyer SJ, Hamond GD, Kersey JH: Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes. J Clin Invest 93:429, 1994
23. Domer PH, Fakharzadeh SS, Chen C-S, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ: Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci USA 90:7884, 1993
24. Strong RC, Korsmeyer SJ, Parkin JL, Arthur DC, Kersey JH: Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. Blood 65:21, 1985
25. Cimino G, Lo Coco F, Biondi A, Elia L, Luciano A, Croce CM, Masera G, Mandelli F, Canaani E: ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. Blood 82:544, 1993
26. Heerema NA, Arthur DC, Sather H, Albo V, Feusner J, Lange BJ, Steinherz PG, Zelter P, Hammond D, Reaman GH: Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: Impact of the 11q23 breakpoint on outcome: A report of the Childrens Cancer Group. Blood 83:2274, 1994
27. Pui C-H, Frankel LS, Carroll AJ, Raimondi SC, Shuster JJ, Head DR, Crist WM, Land VJ, Pullen DJ, Steuber CP, Behm FG, Borowitz MJ: Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): A collaborative study of 40 cases. Blood 77:440, 1991
28. Pui C-H, Carroll AJ, Raimondi SC, Shuster JJ, Crist WM, Pullen DJ: Childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): An update. Blood 83:2384, 1994 (letter)
29. Downing JR, Head DR, Raimondi SC, Carroll AJ, Curio-Brint AM, Motroni TA, Hulshof MG, Pullen J, Domer PH: The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia. Blood 83:330, 1993
30. Griesinger F, Elfers H, Ludwig W-D, Falk M, Rieder H, Harbott J, Lampert F, Heinze B, Hoelzer D, Thiel E, Riehm H, Wormann B, Fonatsch C, Hiddemann W: Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11). Leukemia 8:542, 1994