The human gene map for performance and health-related fitness phenotypes: The 2001 update

Medicine and Science in Sports and Exercise

Volumn 34, Issue 8, 2002, Pages 1219-1233

  Rankinen, Tuomo ^a   Pérusse, Louis ^a   Rauramaa, Rainer ^a   Rivera, Miguel A ^a   Wolfarth, Bernd ^a   Bouchard, Claude ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; MITOCHONDRIAL DNA;

ADAPTATION; ADULT; ATHLETE; BODY COMPOSITION; ENDURANCE; EXERCISE TOLERANCE; FEMALE; FITNESS; GENE MAPPING; GLUCOSE METABOLISM; HEMOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MUSCLE STRENGTH; PHENOTYPE; PHYSICAL PERFORMANCE; REVIEW; TRAINING;

EID: 0036322089     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-200208000-00001     Document Type: Review

References (131)

1. Genetic variation in the renin-angiotensin system and athletic performance
2. A nonsense mutation (G15059A) in the cytochrome b gene in a patient with exercise intolerance and myoglobinuria
3. Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy
4. Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA
5. Exercise intolerance due to a nonsense mutation in the mtDNA ND 4 gene
6. Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins
7. Carnitine palmitoyltransferase deficiencies
8. Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study
9. Bradykinin B2BKR receptor polymorphism and left-ventricular growth response
10. A splice junction mutation in the alpha(M) gene of phosphorylase kinase in a patient with myopathy
11. The association between the val/ala- 55 polymorphism of the uncoupling protein 2 gene and exercise efficiency
12. In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans
13. Clinical heterogeneity in two pedigrees with the 3243 bp tRNA(L-eu(UUR)) mutation of mitochondrial DNA
14. Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE
15. Very low levels of the mtDNA A 3243G mutation associated with mitochondrial dysfunction in vivo
16. Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis
17. Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: Ecogenetic studies in a Mediterranean Spanish population
18. Haptoglobin polymorphism and peripheral arterial occlusive disease
19. Mutations in mitochondrial DNA as a cause of exercise intolerance
20. Mitochondrial DNA sequence poly-morphism, VO2max, and response to endurance training
21. A novel gly 290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance
22. RAS genes influence exercise-induced left ventricular hypertrophy: An elite athletes study
23. Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload
24. Insertion/deletion polymorphism in the angiotensin-converting-enzyme gene and blood pressure during ergometry in normal males
25. Insertion/deletion polymorphism in the angiotensin-converting enzyme gene is associated with atrial natriuretic peptide activity after exercise
26. Evidence of LPL gene-exercise interaction for body fat and LPL activity: The HERITAGE Family Study
27. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not associated with training-induced changes in body composition: The HERITAGE Family Study
28. Elite endurance athletes and the ACE I allele: The role of genes in athletic performance
29. Quadriceps and grip strength are related to vitamin D receptor genotype in elderly nonobese women
30. Abnormal pulmonary artery pressure response in asymptomatic carriers of primary pulmonary hypertension gene
31. Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene
32. Exercise training-induced blood pressure and plasma lipid improvements in hypertensives may be genotype dependent
33. Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men
34. VO 2 max is associated with ACE genotype in postmenopausal women
35. Phosphoglycerate kinase deficiency: An adult myopathic form with a novel mutation
36. Cytochrome c oxidase deficiency associated with the first stop-codon point mutation in human mtDNA
37. Segregation patterns of a novel mutation in the mitochondrial tRNA glutamic acid gene associated with myopathy and diabetes mellitus
38. Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training
39. Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans
40. Enhanced exercise-induced GH secretion in subjects with Pro7 substitution in the prepro-NPY
41. Deletion polymorphisms in the angiotensin converting enzyme gene are associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease
42. Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA
43. Molecular and cellular mechanisms of cardiac arrhythmias
44. Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene
45. A microdeletion in cytochrome c oxidase (COX) subunit III associated with COX deficiency and recurrent myoglobinuria
46. Interplay of physical activity and vitamin D receptor gene polymorphism on bone mineral density
47. Correlation of M235T DNA polymorphism with cardiovascular and endocrine responses during physical exercise in healthy subjects
48. Autosomal recessive catecholamine- or exercise-induced polymorphic ventricular tachycardia: Clinical features and assignment of the disease gene to chromosome 1p13-21
49. Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia
50. Vitamin D receptor gene polymorphism is related to bone density, circulating osteocalcin, and parathyroid hormone in healthy adolescent girls
51. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency
52. Identification of novel mutations in Spanish patients with muscle carnitine palmitoyltransferase II deficiency
53. Myopathy due to a defect in muscle glycogen breakdown
54. Beta2-adrenoceptor gene polymorphism, body weight, and physical activity
55. Angiotensinconverting-enzyme gene insertion/deletion polymorphism and response to physical training
56. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training
57. The acute rise in plasma fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the beta-fibrinogen gene
58. Human gene for physical performance
59. Obesity gene variant and elite endurance performance
60. Lipomatosis, proximal myopathy, and the mitochondrial 8344 mutation: A lipid storage myopathy?
61. Relationship between mitochondrial DNA polymorphism and the individual differences in aerobic performance
62. Intragenic inversion of mtDNA: A new type of pathogenic mutation in a patient with mitochondrial myopathy
63. Human angiotensin I-converting enzyme gene and endurance performance
64. Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: A randomized controlled trial with losartan
65. The angiotensin converting enzyme I/D polymorphism in Russian athletes
66. Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint exercise in asymptomatic subjects
67. Polymorphism of the beta 3-adrenergic receptor gene in morbid obesity
68. Retarded and aberrant splicings caused by single exon mutation in a phosphoglycerate kinase variant
69. A genetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity
70. Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management part III
71. Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management parts I and II
72. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia
73. A novel mutation in the mitochondrial tRNA(TYr) gene associated with exercise intolerance
74. Genomic scan for exercise blood pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study
75. AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study
76. The Na(+)-K(+)-ATPase alpha2 gene and trainability of cardiorespiratory endurance: The HERITAGE family study
77. Angiotensin-converting enzyme ID polymorphism and fitness phenotype in the HERITAGE Family Study
78. The human gene map for performance and health-related fitness phenotypes
79. NOS3 Glu298 Asp genotype and blood pressure response to endurance training: The HERITAGE family study
80. Physical activity, fibrinogen plasma level and gene polymorphisms in postmenopausal women
81. The RsaI polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training: A controlled randomised clinical trial in men
82. Muscle-specific creatine kinase gene polymorphism and VO2max in the HERITAGE Family Study
83. Angiogenin gene-race interaction for resting and exercise BP phenotypes: The HERITAGE Family Study
84. TGF-beta(1) gene-race interactions for resting and exercise blood pressure in the HERITAGE Family Study
85. Linkage between a muscle-specific CK gene marker and VO 2max in the HERITAGE Family Study
86. Could the A2A11 human leucocyte antigen locus correlate with maximal aerobic power?
87. CNTF genotype is associated with muscular strength and quality in humans across the adult age span
88. Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 d, and insulin resistance in obese type 2 diabetic patients
89. Independent and interactive effects of apolipoprotein E phenotype and cardiorespiratory fitness on plasma lipids
90. Myopathy in very-long-chain acyl-CoA dehydrogenase deficiency: Clinical and biochemical differences with the fatal cardiac phenotype
91. Genotypephenotype correlation in the long-QT syndrome: Gene-specific triggers for life-threatening arrhythmias
92. Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the Women's Health and Aging Study II cohort
93. Effect of physical activity on lipid levels in a population-based sample of men with and without the Arg 192 variant of the human paraoxonase gene
94. Physical activity modulates the combined effect of a common variant of the lipoprotein lipase gene and smoking on serum triglyceride levels and highdensity lipoprotein cholesterol in men
95. Common mutations in the phosphofructokinase-M gene in Ashkenazi Jewish patients with glycogenesis VII: And their population frequency
96. Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: The Limone sul Garda study
97. Angiotensin converting enzyme genotype and physical performance during US Army basic training
98. A novel missense mutation (837T->C) in the phosphoglycerate kinase gene of a patient with a myopathic form of phosphoglycerate kinase deficiency
99. Association and linkage between an insulin-like growth factor-1 gene polymorphism and fat free mass in the HERITAGE Family Study
100. Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects
101. Novel mutations associated with carnitine palmitoyltransferase II deficiency
102. The effect of physical activity on serum total and low-density lipoprotein cholesterol concentrations varies with apolipoprotein E phenotype in male children and young adults: The Cardiovascular Risk in Young Finns Study
103. Interaction of the effects between vitamin D receptor polymorphism and exercise training on bone metabolism
104. Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans
105. Identification of a common mutation in the carnitine palmitoyltransferase II gene in familial recurrent myoglobinuria patients
106. The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people
107. Molecular basis of muscle phosphoglycerate mutase (PGAM-M) deficiency in the Italian kindred
108. Identification of three novel mutations in non-Ashkenazi Italian patients with muscle phosphofructokinase deficiency
109. Molecular genetic studies of muscle lactate dehydrogenase deficiency in white patients
110. Molecular genetic heterogeneity of myophosphorylase deficiency (McArdle's disease)
111. Molecular genetic heterogeneity of phosphoglycerate kinase (PGK) deficiency
112. The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency
113. A splice junction mutation in a new myopathic variant of phosphoglycerate kinase deficiency (PGK North Carolina)
114. Does vitamin D receptor polymorphism influence the response of bone to brisk walking in postmenopausal women?
115. Regular exercise, plasminogen activator inhibitor-1 (PAI-1) activity and the 4G/5G promoter polymorphism in the PAI-1 gene
116. Association of the type I collagen alpha1 Sp1 polymorphism, bone density and upper limb muscle strength in community-dwelling elderly men
117. A new mitochondrial tRNA(Met) gene mutation in a patient with dystrophic muscle and exercise intolerance
118. Exercise intolerance resulting from a muscle-restricted mutation in the mitochondrial tRNA(Leu (CUN)) gene
119. A variable myopathy associated with heterozygosity for the R 503C mutation in the carnitine palmitoyltransferase II gene
120. Muscle phosphofructokinase deficiency in two generations
121. Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure
122. Mitochondrial diseases in man and mouse
123. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
124. Human muscle glycogenosis due to phosphorylase kinase deficiency associated with a nonsense mutation in the muscle isoform of the alpha subunit
125. Multisystem disorder associated with a missense mutation in the mitochondrial cytochrome b gene
126. The ACE gene and muscle performance
127. A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status
128. Elite swimmers and the D allele of the ACE I/D polymorphism
129. Angiotensin-I converting enzyme genotype-dependent benefit from hormone replacement therapy in isometric muscle strength and bone mineral density
130. Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo
131. The machinery of mitochondrial inheritance and behavior