Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans

Journal of Physiology

Volumn 533, Issue 3, 2001, Pages 881-889

  Tarnopolsky, Mark A ^a,d   Parise, Gianni ^a   Gibala, Martin J ^a   Graham, Terry E ^b   Rush, James W E ^c  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

^c UNIVERSITY OF WATERLOO   (Canada)

^d MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; ADENOSINE PHOSPHATE; AMINO ACID; CITRIC ACID; CREATINE; CREATINE PHOSPHATE; FUMARIC ACID; INOSINE PHOSPHATE; MALIC ACID; NUCLEIC ACID BASE; PURINE NUCLEOSIDE; PURINE NUCLEOTIDE; TRICARBOXYLIC ACID; ADENOSINE DIPHOSPHATE;

ADULT; ARTICLE; BICYCLE ERGOMETRY; CITRIC ACID CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME DEFICIENCY; EXERCISE; EXHAUSTION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; HYDROLYSIS; KNOCKOUT GENE; METABOLIC DISORDER; MUSCLE BIOPSY; MUTATION; PATIENT CODING; PHYSIOLOGY; PRIORITY JOURNAL; THEORY; VASTUS LATERALIS MUSCLE; AMINO ACID ANALYSIS; AMPD1 GENE; CELL ENERGY; COMPARATIVE STUDY; ENERGY CHARGE; ERGOMETRY; EXHAUSTIVE EXERCISE; GENE INACTIVATION; HETEROZYGOTE; HOMOZYGOTE; INCREMENTAL CYCLE ERGOMETRY; MOLECULAR DYNAMICS; MUSCLE ANAPLEROSIS; MUSCLE METABOLISM; MUTATIONAL ANALYSIS; MYOADENYLATE DEAMINASE DEFICIENCY; PARAMETERS; TIME TO EXHAUSTION;

ADULT; AMINO ACIDS; AMP DEAMINASE; CITRIC ACID CYCLE; CREATINE; ENERGY METABOLISM; EXERCISE; EXERCISE TEST; HUMANS; MUSCLE, SKELETAL; NUCLEOSIDES; NUCLEOTIDES; PHOSPHOCREATINE; PHYSICAL ENDURANCE;

EID: 0035875157     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.t01-1-00881.x     Document Type: Article

References (32)

1. 2+ release in mammalian skeletal muscle
2. Primary, secondary, and coincidental types of myoadenylate deaminase deficiency
3. Myoadenylate deaminase deficiency: A new disease of muscle
4. Medical implications of the lactate and ammonia relationship in anaerobic exercise
5. Importance of purine nucleotide cycle to energy production in skeletal muscle
6. Anaplerotic processes in human skeletal muscle during brief dynamic exercise
7. Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cycling
8. Training and muscle ammonia and amino acid metabolism in humans during prolonged exercise
9. Clinical heterogeneity and molecular mechanisms in inborn muscle AMP deaminase deficiency
10. Amino acid analysis by reverse phase high-performance liquid chromatography: Precolumn derivatization with phenylisothiocyanate
11. Control of AMP deaminase 1 binding to myosin heavy chain
12. Familial myoadenylate deaminase deficiency and exertional myalgia
13. AMP deamination and IMP reamination in working skeletal muscle
14. Myogenic hyperuricemia: What can we learn from metabolic myopathies?
15. Molecular basis of AMP deaminase deficiency in skeletal muscle
16. Muscle AMP deaminase deficiency in 2% of a healthy population
17. Genetic and other determinants of AMP deaminase activity in healthy adult skeletal muscle
18. Molecular and kinetic alterations of muscle AMP deaminase during chronic creatine depletion
19. Molecular analysis of the myoadenylate deaminase deficiencies
20. Disruption of the purine nucleotide cycle: A potential explanation for muscle dysfunction in myoadenylate deaminase deficiency
21. Adenine nucleotide depletion in human muscle during exercise: Causality and significance of AMP deamination
22. Tricarboxylic acid cycle intermediates during incremental exercise in healthy subjects and in patients with McArdle's disease
23. Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise
24. Myoadenylate deaminase deficiency
25. AMP deaminase deficiency: Study of the human skeletal muscle purine metabolism during ischemic isometric exercise
26. Carbohydrate loading and metabolism during exercise in males and females
27. Clinical, physiological, and histological features in a kindred with the T3217C MELAS mutation
28. Direct measurement of high energy phosphate compounds in patients with neuromuscular disease
29. The clinical utility of the forearm ischemic test lactate/ammonia response in the diagnosis of neuromuscular disorders: Insights into mitochondrial cytopathies and myoadenylate deaminase deficiency
30. Adenine nucleotide degradation in slow-twitch red muscle
31. Genetic characteristics of myoadenylate deaminase deficiency