Truncated SNAP-25 (1-197), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells

Molecular Endocrinology

Volumn 12, Issue 7, 1998, Pages 1060-1070

  Huang, X ^a   Wheeler, M B ^a   Kang, Y H ^a   Sheu, L ^a   Lukacs, G L ^a   Trimble, W S ^a   Gaisano, H Y ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; CALCIUM; GLUCOSE; INSULIN; POTASSIUM; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; ELECTRON MICROSCOPY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; INHIBITION KINETICS; INSULIN RELEASE; INSULINOMA; MEMBRANE DEPOLARIZATION; MICROFLUOROMETRY; NONHUMAN; PRIORITY JOURNAL; SYNAPSE VESICLE;

EID: 0032230364     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.7.0130     Document Type: Article

References (29)

1. 2+ and G-proteins
2. The synaptic vesicle cycle: A cascade of protein-protein interactions
3. Implications of the SNARE hypothesis for intracellular membrane topology and dynamics
4. SNAP-25 a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils
5. Synaptic vesicle membrane fusion complex: Action of clostridial neurotoxins on assembly
6. Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion
7. VAMP-2 and cellubrevin are expressed in pancreatic β cells and are essential for calcium but not for GTPγS-induced insulin secretion
8. Characterization of SNARE protein expression in β cell lines and pancreatic islets
9. SNAP-25 is expressed in islets of Langerhans and is involved in insulin release
10. Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells
11. The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations
12. Clostridial neurotoxins: New tools for dissecting exocytosis
13. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
14. Proteolysis of SNAP-25 by types E and A botulinal neurotoxins
15. Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro
16. SNAP-25 is required for a late post-docking step in calcium-dependent exocytosis
17. A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells
18. Calcium-dependent interaction of N-type calcium channels with the synaptic core complex
19. Functional interaction of syntaxin and SNAP-25 with voltage-dependent-sensitive L- and N-type channels
20. Botulinum A and the light chain of tetanus toxins inhibit distinct stages of MgATP-dependent catecholamine exocytosis from permeabilized chromaffin cells
21. Soluble SNAP and NEM-insensitive factors are required for calcium stimulated exocytosis of insulin
22. Ion channels and insulin secretion
23. The effect of botulinum neurotoxins on the release of insulin from the insulinoma cell lines HIT-T15 and RINm5F
24. Fuel-stimulated insulin secretion by clonal hamster β cell line HIT T15
25. Stimulus-response coupling in insulin-secreting HIT cells
26. Expression and functional role of syntaxin 1/HPC-1 in pancreatic β cells
27. Co-localization of L-type calcium channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic β cells
28. Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells
29. Calcium release by the cholecystokinin analog, CCK-OPE is IP3-dependent in single rat pancreatic acinar cells