MDS1/EVI-1, a new member of PR domain protein involved in tumorigenesis;MDS1/EVI-1, un membre de la famille des gènes codant pour des protéines à domaine PR impliqués dans la régulation de la tumorigénicité

Hematologie

Volumn 8, Issue 2, 2002, Pages 121-128

  Legros, Laurence ^a   Raynaud, Sophie ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Leukemia; MDS1 EVI 1; Myelodysplastic syndrome

Indexed keywords

PROTEIN EVI 1; PROTEIN MDS1; REPRESSOR PROTEIN; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

CARCINOGENESIS; CELL TRANSFORMATION; CHROMOSOME 3Q; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC CODE; HEMATOPOIETIC CELL; LEUKEMIA CELL; PROTEIN DOMAIN; REVIEW;

EID: 0036313812     PISSN: 12647527     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (44)

1. PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumar suppressor locus on human chromosome 12q23-q24.1
2. The yin-yang of PR-domain family genes in tumorigenesis
3. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression
4. Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors
5. Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter
6. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines
7. Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: Sequence of cDNAs and structure of alternatively spliced transcripts
8. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family
9. Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins
10. Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA
11. The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG
12. Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations
13. Detection of an MDS1-EVI-1 fusion transcript in normal tissues and in leukemic cell lines
14. The Evi-1 zinc finger myeloid transforming gene is normally expressed in the kidney and in developing oocytes
15. Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translacations
16. Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26
17. Expression of the Evi-1 gene in myelodysplastic syndromes
18. Evi-1 expression in leukemic patients with rearrangements of the 3q25-q28 chromosomal region
19. Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development
20. The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development
21. Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimuloting factor
22. Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene
23. Erythroid defects and increased retrovirally-induced tumor formation in Evil transgenic mice
24. The Evi-1 zinc finger myeloid transforming protein binds to genomic fragments containing (GATA)n sequences
25. The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation
26. The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3
27. Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivotion with dependence on the second zinc finger domain
28. The leukemia-associated gene MDS1/EVI1 is a new type of GATA-binding transactivator
29. MDS1/EVI1 enhances TGF-beta1 signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-beta1
30. t(3;21)(q26;q22): A recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia
31. Expression of the EVI1 gene in chronic myelogenous leukemia in blast crisis
32. The 3;21 translocatian in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved pratein associated with the Epstein-Barr virus small RNA EBER 1
33. Rearrangements of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: In vitro and in vivo studies
34. The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2beta(CBFbeta) in the nucleus more efficiently than wild-type AMLI
35. The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence
36. The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells
37. Fluorescence in situ hybridization analysis af t(3;12)(q26;p13): A recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes
38. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders
39. Correlation of cytogenetic findings with clinical features in 18 patients with inv(3) (q21q26) or t(3;3)(q21;q26)
40. Molecular analysis of transferrin (TF), transferrin receptor (TFR), and p97 antigen genes in the inv(3;3) and t(3;3) in acute nonlymphocytic leukemia (ANLL)
41. The human thrombopoietin gene is located on chromosome 3q26.33-q27, but is not transcriptionally activated in leukemia cells with 3q21 and 3q26 abnormalities (3q21q26 syndrome)
42. Identification of a breakpoint cluster region 3′ of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26)
43. DNA rearrangements proximal to the EVI1 locus associated with the 3q21q26 syndrome
44. Molecular anolyses of rare chromosomal abnormalities involving the MDS1-EVI1 locus at 3q26 in myeloid disorders