Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice

Leukemia

Volumn 14, Issue 11, 2000, Pages 1876-1884

  Louz, D ^a   Van Den Broek, M ^a   Verbakel, S ^a   Vankan, Y ^a   Van Lom, K ^a   Joosten, M ^a   Meijer, D ^a   Lowenberg B ^a   Delwel, R ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Dyserythropoiesis; Evi1 transgenic mice; Leukemogenesis

Indexed keywords

VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CANCER INCIDENCE; CANCER SUSCEPTIBILITY; COLONY FORMING UNIT E; CONTROLLED STUDY; ECOTROPIC VIRUS; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; HEMATOLOGIC DISEASE; HEMATOPOIESIS; IN VIVO STUDY; LEUKEMOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTO ONCOGENE; RETROVIRUS; SPLEEN; TRANSGENIC MOUSE; TUMOR GROWTH; VIRUS CARCINOGENESIS; VIRUS DNA CELL DNA INTERACTION;

EID: 0033768475     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401887     Document Type: Article

References (39)

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2. Evi-1 expression in leukemia patients with rearrangements of the 3q25-q28 chromosomal region
3. Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26
4. Identification of a breakpoint cluster region 3' of the ribophorin 1 gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26)
5. Acute leukemia with abnormal thrombopoiesis and inversions of chromosome 3
6. The human Evi-1 gene is located on chromosome 3q24-q28 but is not rearranged in three cases of acute nonlymphocytic leukemias containing t(3;5)(q25;q34) translocations
7. Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations
8. Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia
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10. Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C) AAGATAA
11. Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein
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13. An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes
14. GATA transcription factors: Key regulators of hematopoiesis
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32. The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets
33. Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family
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