Preparation of alkyl-substituted indoles in the benzene portion. Part 15. Asymmetric synthesis of (+)-duocarmycin SA using novel procedure for preparation of hydroxyindoles

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 4, 1998, Pages 559-571

  Muratake, Hideaki ^a   Matsumura, Naoshige ^a   Natsume, Mitsutaka ^a  

^a Kawasaki   (Japan)

Author keywords

Absolute configuration establishment; Alkoxyindole formation reaction; Asymmetric total synthesis; Duocarmycin SA; Potent antitumor substance

Indexed keywords

5 BENZYL 2 METHYL 4 [2,3 DI(BENZYLOXY) PROPYL] 7 (3 HYDROXYPROPYLOXY) 1H INDOLE 2,5 DICARBOXYLIC ACID; ANTINEOPLASTIC AGENT; DUOCARMYCIN SA; INDOLE DERIVATIVE; METHYL 5 [2 (2 ACETAMIDO 3 OXO 1 HEXYL) 1,3 DIOXOLAN 2 YL] 1H PYRROLE 2 CARBOXYLIC ACID; METHYL 6,7,8,9 TETRAHYDRO 4,8 DIHYDROXY 6 (METHOXYCARBONYL) 3H PYRROLO[3,2 F]QUINOLINE 2 CARBOXYLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0031979279     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.559     Document Type: Article

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