p53 blocks RuvAB promoted branch migration and modulates resolution of Holliday junctions by RuvC

Journal of Molecular Biology

Volumn 316, Issue 5, 2002, Pages 1023-1032

  Prabhu, Vidya P ^a   Simons, Amanda M ^a   Iwasaki, Hiroshi ^b   Gai, Dahai ^a   Simmons, Daniel T ^a   Chen, Junghuei ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Branch migration; Holliday junction; p53; RuvAB; RuvC

Indexed keywords

PROTEIN; PROTEIN P53; PROTEIN RUVAB; PROTEIN RUVC; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND; DNA STRUCTURE; GENETIC RECOMBINATION; HOLLIDAY JUNCTION; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

EUKARYOTA;

EID: 0036308710     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5408     Document Type: Article

References (48)

1. p53, guardian of the genome
2. The p53 pathway
3. Twenty years of p53 research: Structural and functional aspects of the p53 protein
4. Surfing the p53 network
5. Regulation of p53 in response to DNA damage
6. Links between replication, recombination and genome instability in eukaryotes
7. Initiation of genetic recombination and recombination-dependent replication
8. Recombination: A frank view of exchanges and vice versa
9. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction
10. Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia
11. In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes
12. Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein
13. Inactivation of p53 results in high rates of homologous recombination
14. Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination
15. p53 abnormalities and genomic instability in primary human breast carcinomas
16. Human p53 binds Holliday junctions strongly and facilitates their cleavage
17. A mechanism for gene conversion in fungi
18. Identification of double Holliday junctions as intermediates in meiotic recombination
19. The kinetics of spontaneous DNA branch migration
20. Processing the Holliday junction in homologous recombination
21. Processing of recombination intermediates by the RuvABC proteins
22. Holliday junction processing in bacteria: Insights from the evolutionary conservation of RuvABC, RecG and RusA
23. Cleavage of Holliday junctions by the Escherichia coli RuvABC complex
24. Branch migration and Holliday junction resolution catalyzed by activities from mammalian cells
25. Branch migration through DNA sequence heterology
26. Migration of a Holliday junction through a nucleosome directed by the E. coli RuvAB motor
27. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
28. Analysis of substrate specificity of the RuvC holliday junction resolvase with synthetic Holliday junctions
29. The role of metal ions in the conformation of the four-way DNA junction
30. Structural analysis of the RuvC-Holliday junction complex reveals an unfolded junction
31. p53-catalyzed annealing of complementary single-stranded nucleic acids
32. p53 modulation of TFIIH-associated nucleotide excision repair activity
33. Cleavage of cruciform DNA structures by an activity from Saccharomyces cerevisiae
34. Partial purification of an enzyme from Saccharomyces cerevisiae that cleaves Holliday junctions
35. Resolution of synthetic Holliday junctions in DNA by an endonuclease activity from calf thymus
36. Resolution of recombination intermediates by a mammalian activity functionally analogous to Escherichia coli RuvC resolvase
37. DNA double-strand breaks: Signaling, repair and the cancer connection
38. The Bloom's syndrome gene product is homologous to RecQ helicases
39. Positional cloning of the Werner's syndrome gene
40. The Werner syndrome protein is a DNA helicase
41. The Bloom's syndrome gene product is a 3′-5′ DNA helicase
42. The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells
43. The Bloom's syndrome gene product promotes branch migration of holliday junctions
44. Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
45. The Werner syndrome protein contributes to induction of p53 by DNA damage
46. Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
47. p53 mutants with changes in conserved region II: Three classes with differing antibody reactivity. SV40 T antigen binding and ability to inhibit transformation of rat cells
48. Coordinated actions of RuvABC in Holliday junction processing