In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system

Journal of Molecular Biology

Volumn 318, Issue 1, 2002, Pages 9-20

  Ohlmann, Théophile ^a   Prévôt, Déborah ^a   Décimo, Didier ^a   Roux, Florence ^b   Garin, Jérôme ^b   Morley, Simon J ^c   Darlix, Jean Luc ^a  

^a UNIVERSITÉ DE LYON   (France)

^b CEA GRENOBLE   (France)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

eIF4G HIV 1; Initiation factor; IRES; Translation

Indexed keywords

CELL EXTRACT; PROTEIN EIF4GI; PROTEIN EIF4GII; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EUKARYOTIC CELL; GENOME; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PICORNAVIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RABBIT; REGULATORY MECHANISM; RETICULOCYTE LYSATE; RIBOSOME SUBUNIT; RNA CAPPING; RNA TRANSLATION; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS EXPRESSION;

EUKARYOTA; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS; PICORNAVIRIDAE; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0036308653     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00070-0     Document Type: Article

References (44)

1. eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
2. Effects of long 5′ leader sequences on initiation by eukaryotic ribosomes in vitro
3. Eukaryotic translation initiation: There are (at least) two sides to every story
4. Translational controls impinging on the 5′-untranslated region and initiation factor proteins
5. Initiation of protein synthesis in eukaryotic cells
6. Starting at the beginning, middle, and end: Translation initiation in eukaryotes
7. eIF4G: Translation's mystery factor begins to yield its secrets
8. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins
9. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation
10. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
11. Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region
12. Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F
13. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
14. eIF4G dramatically enhances the binding of eIF4E to the mRNA 5′-cap structure
15. Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells
16. Translational control of viral gene expression in eukaryotes
17. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex
18. Foot-and-mouth disease virus leader proteinase: Purification of the Lb form and determination of its cleavage site on eIF-4 gamma
19. The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase
20. The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate
21. Specific interaction of eukaryotic translation initiation factor 3 with the 5′ nontranslated regions of hepatitis C virus and classical swine fever virus RNAs
22. Functional dissection of eukaryotic initiation factor 4F: The 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes
23. The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E
24. elF4G and its proteolytic cleavage products: Effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs
25. Translational activation of uncapped mRNAs by the central part of human eIF4G is 5′ end-dependent
26. A novel functional human eukaryotic translation initiation factor 4G
27. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
28. Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection
29. Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis
30. Lenti-virus replication and regulation
31. An internal ribosome entry segment promotes translation of the simian immunodeficiency virus genomic RNA
32. The human immunodeficiency virus type 1 gag gene encodes an internal ribosome entry site
33. HIV-1 protease: Maturation, enzyme specificity, and drug resistance
34. Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection
35. Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2
36. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs
37. Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin
38. Conserved folding in retroviral proteases: Crystal structure of a synthetic HIV-1 protease
39. An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity
40. Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation
41. Caspase-3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis
42. The properties of chimeric picornavirus IRESes show that discrimination between internal translation initiation sites is influenced by the identity of the IRES and not just the context of the AUG codon
43. Cis elements and transacting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1
44. Proteolytic cleavage of initiation factor eIF-4 gamma in the reticulocyte lysate inhibits translation of capped mRNAs but enhances that of uncapped mRNAs