Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis

Cell Death and Differentiation

Volumn 7, Issue 12, 2000, Pages 1234-1243

  Marissen, W E ^a,b   Gradi, A ^c   Sonenberg, N ^c   Lloyd, R E ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Apoptosis; Caspase; elF4G; Protein synthesis inhibition; Translation initiation factor

Indexed keywords

CAPPED RNA; CASPASE 3; CISPLATIN; INITIATION FACTOR 4G; MESSENGER RNA; RNA BINDING PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENTEROVIRUS; ENTEROVIRUS INFECTION; ENZYME SUBSTRATE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; KINETICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN RNA BINDING; RIBOSOME SUBUNIT; RNA CLEAVAGE; RNA TRANSLATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CISPLATIN; EUKARYOTIC INITIATION FACTOR-4G; HELA CELLS; HUMANS; JURKAT CELLS; K562 CELLS; PEPTIDE FRAGMENTS; PEPTIDE INITIATION FACTORS; PROTEIN BIOSYNTHESIS; RNA, MESSENGER;

EID: 0034517764     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400750     Document Type: Article

References (37)

1. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis
2. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation
3. p53-independent anisomycin induced G1 arrest and apoptosis in L1210 cell lines
4. Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism
5. Depletion of intracellular zinc induces protein synthesis-dependent neuronal apoptosis in mouse cortical culture
6. Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs
7. Mercuric chloride-induced apoptosis is dependent on protein synthesis
8. Potassium deprivation-induced apoptosis of cerebellar granule neurons: A sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species
9. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (elF4G) with picornaviral proteases - Implications for cap-dependent and cap-independent translational initiation
10. elF4G - Translation's mystery factor begins to yield its secrets
11. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eukaryotic initiation factor 3 and a cap binding protein complex
12. Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex
13. RNA-Protein interactions in regulation of picornavirus RNA translation
14. Poliovirus 2A protease induces apoptotic cell death
15. Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells
16. A novel functional human eukaryotic translation initiation factor 4G
17. TIF4631 and TIF4632 - 2 yeast genes encoding the High-molecular-weight subunits of the cap-binding protein complex (Eukaryotic initiation Factor-4F) contain an RNA recognition motif-like sequence and carry out an essential function
18. Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation Factor-4F
19. Proteolysis of human eukaryotic translation initiation factor elF4Gll, but not elF4Gl, coincides with the shutoff of host protein synthesis after poliovirus infection
20. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4Gl
21. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
22. Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated elF-4E
23. A newly identified N-terminal amino acid sequence of human elF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
24. Butyric acid-induced apoptosis of murine thymocytes, splenic T cells, and human Jurkat T cells
25. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
26. Caspase-3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis
27. Substrate specificities of caspase family proteases
28. Cleavage of polypeptide chain initiation factor elF4Gl during apoptosis: Characterisation of an internal fragment generated by caspase-3-mediated cleavage
29. Eukaryotic initiation factor 4Gll (elF4Gll), but Not elF4Gl, Cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection
30. Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis
31. Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2α in apoptosis
32. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2α
33. The large subunit of replication factor c is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during fas-mediated apoptosis
34. elF4G and its proteolytic cleavage products: Effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs
35. The c-terminal domain of eukaryotic protein synthesis initiation factor (elF) 4G is sufficient to support cap-independent translation in the absence of elF4E
36. Translation driven by an elF4G core domain in vivo
37. Eukaryotic translation initiation factor 4E (elF4E) site and the middle one-third of elF4Gl constitute the core domain for cap-dependent translation, and the C-terminal on-third functions as modulatory region