Improving coiled-coil stability by optimizing ionic interactions

Journal of Molecular Biology

Volumn 318, Issue 3, 2002, Pages 901-910

  Burkhard, Peter ^a   Ivaninskii, Sergei ^a   Lustig, Ariel ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Coiled coil; Ionic interactions; Protein de novo design; Protein folding; Protein oligomerization

Indexed keywords

PEPTIDE;

ALPHA HELIX; ARTICLE; CIRCULAR DICHROISM; MOLECULAR INTERACTION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; ULTRACENTRIFUGATION;

EID: 0036307698     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00114-6     Document Type: Article

References (38)

1. Design of a minimal protein oligomerization domain by a structural approach
2. Design of a 20-amino acid, three-stranded beta-sheet protein
3. High-resolution protein design with backbone freedom
4. Protein design: A hierarchic approach
5. Design of a monomeric 23-residue polypeptide with defined tertiary structure
6. A synthetic peptide ligase
7. Designed four-helix bundle catalysts: The engineering of reactive sites for hydrolysis and trans-esterification reactions of p-nitrophenyl esters
8. An engineered allosteric switch in leucine-zipper oligomerization
9. Coiled coils: New structures and new functions
10. Coiled coils: A highly versatile protein folding motif
11. The packing of α-helices: Simple coiled coils
12. Spare the rod, spoil the regulation: Necessity for a myosin rod
13. Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides. Implications for motor activity
14. A distinct 14 residue site triggers coiled-coil formation in cortexillin I
15. Structural properties of the myosin-II coiled-coil assembly domain
16. An autonomous folding unit mediates the assembly of two-stranded coiled coils
17. The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges
18. A conserved C-terminal assembly region in paramyosin and myosin rods
19. Helix design, prediction and stability
20. Stability of alpha-helices
21. Surface salt bridges stabilize the GCN4 leucine zipper
22. An intrahelical salt bridge within the trigger site stabilizes the GCN4 leucine zipper
23. Effect of amino acid ion pairs on peptide helicity
24. Helical peptides with three pairs of Asp-Arg and Glu-Arg residues in different orientations and spacings
25. Understanding and increasing protein stability
26. Complex salt bridges in proteins: Statistical analysis of structure and function
27. Surface design of an alpha helical protein
28. A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants
29. The role of position a in determining the stability and oligomerization state of alpha-helical coiled coils: 20 Amino acid stability coefficients in the hydrophobic core of proteins
30. Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled-coil: 20 Amino acid substitutions in position "d"
31. Interhelical salt bridges, coiled-coil stability, and specificity of dimerization
32. Interhelical salt bridges, coiled-coil stability, and specificity of dimerization
33. Inter-helical interactions in the leucine zipper coiled coil dimer: pH and salt dependence of coupling energy between charged amino acids
34. Orientation, positional, additivity, and oligomerization-state effects of interhelical ion pairs in alpha-helical coiled-coils
35. The penultimate rotamer library
36. Refinement of macromolecular structures by the maximum-likelihood method