Designed four-helix bundle catalysts - The engineering of reactive sites for hydrolysis and transesterification reactions of p-nitrophenyl esters

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 1, 1999, Pages 83-91

  Baltzer, Lars ^a   Broo, Kerstin S ^a   Nilsson, Helena ^a   Nilsson, Jonas ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Catalysis; De novo design; Ester hydrolysis; Four helix bundle; Reactive site

Indexed keywords

ARTICLE; CATALYSIS; CATALYST; DRUG DESIGN; ESTERIFICATION; HYDROLYSIS; IN VITRO STUDY; MODEL; MOLECULAR DYNAMICS; PEPTIDE SYNTHESIS; PROTEIN STRUCTURE; REACTION ANALYSIS; TEMPERATURE;

AMINO ACID SEQUENCE; ARGININE; BINDING SITES; CATALYSIS; ESTERIFICATION; ESTERS; FUMARATES; HELIX-LOOP-HELIX MOTIFS; HISTIDINE; HYDROLYSIS; KINETICS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITROBENZENES; PEPTIDES; PHENYLACETATES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS;

EID: 0033019393     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00218-1     Document Type: Article

References (16)

1. Betz, S. F.; DeGrado, W. F. Biochemistry 1996, 35, 6955.
2. Hodges, R. S. Biochem. Cell Biol. 1996, 74, 133.
3. Dolphin, G. T.; Brive, L.; Johansson, G.; Baltzer, L. J. Am. Chem. Soc. 1996, 118, 11297.
4. Brive, L.; Dolphin, G. T.; Baltzer, L. J. Am. Chem. Soc. 1997, 119, 8598.
5. Hill, R. B.; DeGrado, W. F. J. Am. Chem. Soc. 1998, 117, 1138.
6. Struthers, M. D.; Cheng, R. P.; Impeirali, B. Science 1996, 271, 342.
7. Johnsson, K.; Allemann, R. K.; Widmer, H.; Benner, S. A. Nature 1993, 365, 530.
8. Severin, K.; Lee, H. D.; Kennan, A. J.; Ghadiri, M. R. Nature 1997, 389, 706.
9. Broo, K. S.; Brive, L.; Ahlberg, P.; Baltzer, L. J. Am. Chem. Soc. 1997, 119, 11362.
10. Broo, K. S.; Nilsson, H.; Nilsson, J.; Flodberg, A.; Baltzer, L. J. Am. Chem. Soc. 1998, 120, 4063.
11. Broo, K. S.; Nilsson, H.; Nilsson, J.; Baltzer, L. J. Am. Chem. Soc. 1998, 120, 10287.
12. Broo, K. S.; Baltzer, L., unpublished results.
13. Olofsson, S.; Johansson, G.; Baltzer, L. J. Chem. Soc., Perkin Trans. 2, 1995, 2047.
14. Bryson, J. W.; Betz, S. F.; Lu, H. S.; Suich, D. J.; Zhou, H. X.; O'Neill, K. T.; DeGrado, W. F. Science 1995, 270, 935.
15. Olofsson, S.; Baltzer, L. Folding Des. 1996, 1, 347.
16. Lyu, P. C.; Gans, P. J.; Kallenbach, N. R. J. Mol. Biol. 1992, 223, 343.