Base-sequence specificity of Hoechst 33258 and DAPI binding to five (A/T)4 DNA sites with kinetic evidence for more than one high-affinity Hoechst 33258-AATT complex

Journal of Molecular Biology

Volumn 315, Issue 5, 2002, Pages 1049-1061

  Breusegem, Sophia Y ^a,b   Clegg, Robert M ^b   Loontiens, Frank G ^a  

^a GHENT UNIVERSITY   (Belgium)

^b University of Illinois at Urbana Champaign   (United States)

Author keywords

DNA drug interactions; Fluorescence; High affinity; Hoechst 33258 binding mechanism; Stopped flow

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; 4',6 DIAMIDINO 2 PHENYLINDOLE; 5 BROMOURACIL DERIVATIVE; DNA;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DIFFUSION; DISSOCIATION; DNA BINDING; ISOMERISM; PRIORITY JOURNAL; SIGNAL NOISE RATIO;

EID: 0036306118     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5301     Document Type: Article

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